Journal of Cellular Immunology

2021

Volume 3, Issue 3, p133-200

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Commentary Open Access

Efferocytosis and Anthrax: Implications for Bacterial Sepsis?

Joshua S. Mytych, Zijian Pan, A. Darise Farris

Bacillus anthracis (Ba) is a gram-positive, rod-shaped, spore- and toxin-forming bacterium. While mainly an herbivore pathogen, human infection with Ba spores can occur through a number of routes including cutaneous, gastrointestinal, injectional, or inhalational.

J Cell Immunol, 2021, Volume 3, Issue 3, p133-139 | DOI: 10.33696/immunology.3.090

Review Article Open Access

Ca²⁺/calmodulin-dependent Protein Kinases in Leukemia Development

Changhao Cui, Chen Wang, Min Cao, Xunlei Kang

Calcium (Ca²⁺) is an intracellular universal second messenger that regulates a variety of cellular processes. Many biological processes, including gene transcription, cell cycle, migration, and apoptosis, are affected by changes in intracellular Ca²⁺ signaling. Disruption of normal Ca²⁺ signaling can cause tumorigenic phenotypes.

J Cell Immunol, 2021, Volume 3, Issue 3, p144-150 | DOI: 10.33696/immunology.3.091

Short Communication Open Access

Promoter Reporter Systems for Imaging of Cells Transplanted into Post-infarcted Heart

Katarzyna Fiedorowicz, Maciej Kurpisz

Recently, stem/progenitor cell therapies have been intensively pursued. An increasing body of evidence has shown the promising results with respect to transient recovery of cardiac function in a variety of animal models with the use of stem cells interventions.

J Cell Immunol, 2021, Volume 3, Issue 3, p151-155 | DOI: 10.33696/immunology.3.092

Commentary Open Access

Duration of SARS-CoV-2 Infectivity

Seitz Tamara, Kelani Hasan, Wenisch Christoph, Laferl Hermann

The ongoing SARS-CoV-2 pandemic led to a high number of deaths worldwide as well as an overload of healthcare systems and an economic collapse. One of the reasons can be attributed to the lack of knowledge about the duration of infectivity at the beginning of the pandemic, resulting in hospital isolation of patients and

J Cell Immunol, 2021, Volume 3, Issue 3, p156-163 | DOI: 10.33696/immunology.3.093

Commentary Open Access

Unconventional Approaches to Direct Detection of Borreliosis and Other Tick Borne Illnesses: A Path Forward

Lance Liotta, Alessandra Luchini

The current COVID-19 pandemic has brought to public attention the conceptual difference between a test for COVID-19 derived RNA or proteins indicating the presence of an active infection, versus COVID-19 serology testing indicating pathogen infection. Only the former test for molecules derived from COVID-19 provides reliable

J Cell Immunol, 2021, Volume 3, Issue 3, p164-172 | DOI: 10.33696/immunology.3.094

Short Communication Open Access

Increased Binding Affinity of Furin to D614G Mutant S-glycoprotein May Augment Infectivity of the Predominating SARS-CoV-2 Variant

Sardar Sindhu, Rasheed Ahmad, Fahd Al-Mulla

The coronavirus disease (COVID)-19 pandemic has profoundly devastated human health and wellbeing all over the world, along with colossal setback to global economy in terms of soaring new infections, hospitalizations, ICU admissions, work losses, closures of businesses and institutions, bankruptcies, and precautionary measures

J Cell Immunol, 2021, Volume 3, Issue 3, p173-176 | DOI: 10.33696/immunology.3.095

Commentary Open Access

Murine Models of Alcohol Consumption: Imperfect but Still Potential Source of Novel Biomarkers and Therapeutic Drug Discovery for Alcoholic Liver Disease

Khaled Alharshawi, Costica Aloman

Improving our knowledge regarding the cellular and molecular mechanisms underlying murine models of alcoholic liver injury should enhance the management and therapies of alcoholic liver disease (ALD) seen in humans [1]. Although none of the animal models available reproduce all main aspects of human ALD, they still provide very

J Cell Immunol, 2021, Volume 3, Issue 3, p177-181 | DOI: 10.33696/immunology.3.096

Research Article Open Access

The Variable Immune Response to SARS-CoV-2 Infection and Potential Treatment with Combination IL-15 and IL-21

Stephen William Wilz

SARS-Cov-2 is the virus that causes the disease COVID-19. The disease has led to the worst worldwide health crisis in 100 years. While many patients remain asymptomatic, most patients develop a mild respiratory infection. Symptoms include cough, fever and chills, fatigue and body aches, headache and loss of the sense of taste or

J Cell Immunol, 2021, Volume 3, Issue 3, p182-190 | DOI: 10.33696/immunology.3.097

Research Article Open Access

Sleep Disturbances are a Significant Predictor of Chikungunya Arthritis Flare Severity

Sarah Renee Tritsch, Richard Amdur, Liliana Encinales, Andres Cadena Bonfanti, Paige Fierbaugh, Geraldine Avendaño, Carlos Andres Herrera Gomez, Karol Suchowiecki, Evelyn Mendoza-Torres, Wendy Rosales, Dennys Jimenez, Carlos Alberto Perez Hernandez, Alfonso Sucerquia Hernández, Paula Bruges Silvera, Yerlenis Galvis Crespo, Alberto David Cabana Jimenez, Jennifer Carolina Martinez Zapata, Christopher N. Mores, Gary Steven Firestein, Gary Leonard Simon, Aileen Yu-hen Chang

Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes that causes debilitating arthritis. In a cohort of 500 Colombian patients, one quarter reported joint pain 20 months after infection, and further, 1 out of 8 had joint pain three years after infection.

J Cell Immunol, 2021, Volume 3, Issue 3, p191-197 | DOI: 10.33696/immunology.3.098

Commentary Open Access

The Potential of Combination Therapies and Patient Stratification to Improve CCR₂ Inhibition Therapeutics

Jason E. Duex, Dan Theodorescu

Chemokines and their receptors are the communication mechanism used by cells of the immune system, allowing them to identify and eliminate pathogens and cancerous cells. However, it is becoming clear that chemokines and their receptors are also playing a role in tumor progression and metastasis.

J Cell Immunol, 2021, Volume 3, Issue 3, p198-200 | DOI: 10.33696/immunology.3.099

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Journal of Cellular Immunology

2021

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