Volume 2, Issue 1, p1-61
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Human embryogenesis and the development of its most unique product, the human brain, are believed to be precisely regulated by factors adopted during human
evolution that differentiate us from other species.
Alzheimer disease (AD) is a debilitating neurodegenerative disorder characterized by extracellular deposition of the amyloid β-protein (Aβ) and intraneuronal accumulation of the microtubule-associated protein, tauJ Exp Neurol, 2021, Volume 2, Issue 1, p10-15 | DOI: 10.33696/Neurol.2.029
Cryptogenic stroke (CS) refers to the cerebral infarcts for which no definite cause is identified after adequate diagnostic evaluation. It accounts for 10-15% of all
strokes. Most of the cryptogenic strokes are embolicappearing non-lacunar infarcts based on the radiographic pattern.
Anorexia nervosa (AN) is an eating disorder characterized by a fear of gaining weight and self-starvation, leading to life-threatening weight loss . It occurs predominately in women and frequently begins during adolescence.J Exp Neurol, 2021, Volume 2, Issue 1, p21-28 | DOI: 10.33696/Neurol.2.031
Uromodulin (UMOD) is a glycoprotein expressed by the epithelial cells of the thick ascending limb of Henle’s loop in the kidney. Research has shown that increased uromodulin expression may be associated with lower risk of cardiovascular disease in adults.J Exp Neurol, 2021, Volume 2, Issue 1, p29-33 | DOI: 10.33696/Neurol.2.032
Commentary on “Health-related Quality of Life and Posttraumatic Stress Disorder in Inpatients Injured in the Ludian Earthquake: A Longitudinal Study”
Posttraumatic stress disorder (PTSD) is a common psychiatric disorder after experiencing trauma exposure and characterized by at least one symptom from the four clusters: intrusion, avoidance, negative mood and cognitive alterations, as well as abnormal arousal and reactivityJ Exp Neurol, 2021, Volume 2, Issue 1, p34-38 | DOI: 10.33696/Neurol.2.033
Stroke, Oxygen and Prehospital Care: A Commentary on Current Treatments and Opportunities for Improvement
Stroke is a common and very serious illness where timely evaluation and intervention can have dramatic effects on patient outcomes.J Exp Neurol, 2021, Volume 2, Issue 1, p39-46 | DOI: 10.33696/Neurol.2.034
Posterior circulation tandem occlusion is an area of neurosurgery that has not been heavily studied, particularly in regards to treatment modalities. These strokes occur more rarely than other forms of stroke and, frequently, conventional surgical intervention is no longer an option by the time patients present to the hospital.J Exp Neurol, 2021, Volume 2, Issue 1, p47-48 | DOI: 10.33696/Neurol.2.035
Glutaminergic Signaling in the Nucleus Accumbens Modulates the Behavioral Response to Acute and Chronic Methylphenidate
Methylphenidate (MPD) is a psychostimulant that is widely used to treat attention deficit hyperactivity disorder, and is being increasingly misused as a recreational drug and cognitive enhancerJ Exp Neurol, 2021, Volume 2, Issue 1, p49-61 | DOI: 10.33696/Neurol.2.036
Focal Aggregates of Normal or Near Normal Uveal Melanocytes (FANNUMs) in the Choroid. A Practical Clinical Category of Small Ophthalmoscopically Evident Discrete Melanocytic Choroidal Lesions
Multiple types of discrete melanocytic choroidal lesions are currently recognized, including benign choroidal nevi, choroidal malignant melanomas, patches of choroidal melanocytosis, and foci of choroidal melanocytes stimulated paraneoplastically by a systemic nonmelanoma malignant neoplasm.
The currently ongoing coronavirus pandemic, the SARSCOV- 2, interchangeably referred to as the COVID-19 infection, has in a short span of time altered the ways and means of almost all of mankind. So strong has been its effect that all human activity ceased in one way or another for a considerable time, led to significant loss of life and economic drain of.
Multidisciplinary Acute Care of Central Retinal Artery Occlusion with a Stroke Paradigm: A Call to Action
Central retinal artery occlusion (CRAO) is a painless ophthalmologic emergency with potential for irreversible vision loss. Similar to ischemic stroke, CRAO occurs when there is sudden obstruction of the central retinal artery, leading to ischemic injury to the retina and subsequent cell death. Continuous occlusion and ischemia of the retina progresses to permanent damage to retinal cells and loss of vision.
In a recent paper, we introduced a variant of the classical Simeoni tumor growth model, and illustrated its value in assessing tumor growth in a reproducible mouse model for mammary tumors. Our modification consisted of incorporating delay differential equations in the mathematical formulation of the Simeoni model, to represent the delay in drug action often observed under chemotherapeutic or immunotherapeutic regimens.
There are many exciting developments in the field of midlife women’s health which explain how menopause symptoms, particularly hot flashes, may be an important vital sign and predictor of future health status
Acute Success and Long-term Follow-up of Catheter Ablation of Isthmus-dependent Atrial Flutter; A Comparison of 10 mm Tip Standard, 6 mm Tip Irrigated Radiofrequency, and Cryotherapy Catheters
Various catheter ablation technologies have evolved to improve the procedural success and safety of cavotricuspid isthmus (CTI) block. Numerous studies have compared the different energy types, catheter tip sizes, and energy settings.
Family Planning Laboratory Review of Factors Affecting the Choice of Contraceptive Methods in Three Teenagers' Populations in Thrace, Greece
Contraception encompasses the concept of avoiding a pregnancy, and is aimed at women of reproductive age who, although are sexually active, do not want to achieve any pregnancy at their option fertility preservation and family planning
Patients of all ages with motor disorders expect highquality assessments and evidence- based treatment . In university hospitals, alongside medical training and treatment of patients, research  is an integral part of the skills for medical professionals e.g. doctors, nurses, occupational therapists and physiotherapists.
Molecular Detection of Plasmid - Mediated Quinolone Resistant Genes in Uropathogenic E. coli from Tertiary Referral Hospital in Tehran , Iran
Urinary Tract Infection (UTI) due to Escherichia coli is the most common bacterial infection. Fluoroquinolones are commonly used for the treatment of UTI because isolated microorganisms are frequently resistant to aminopenicillins and trimethoprim- sulfamethoxazole and fluoroquinolones are given orally .
Intentional facial expression of emotion named facial mimic is critical to healthy social interactions. Psychological and functional implications of the facial paralysis present a devastating management problem to patients afflicted because their face have an important challenge of facial muscles that are fundamental also for affective communication.
Influence of Clinical Risk Factors on Outcomes in Men with Stage I Non-Seminomatous Germ Cell Tumor Undergoing Robot-Assisted Retroperitoneal Lymph Node Dissection
Retroperitoneal lymph nodes are often the first landing site of metastatic disease in men with testicular cancer. Primary retroperitoneal lymph node dissection (RPLND) for clinical stage I NSGCT can accurately surgically stage patients who may have nodal micrometastases, and in some cases, can serve as the primary therapy when volume of metastasis is low.
Wound healing is a dynamic process whereby cellular structures and the tissue layers are reconstructed. Adult wound healing can be categorized into three stages: inflammatory phase, proliferative phase, and remodelling phase. Blood cells like macrophages, neutrophils, extracellular matrix and mediators, various proteins, and various genes play an important role in these phases.
STARTTS Capoeira Angola Project Bantu: Combining Alternative Therapeutic Intervention with Sport for Traumatized Young Refugees: On the Way to Recovery
During the last decade, the world experienced an incredible increase in displaced populations; a staggering 70.8 million, which has been a direct outcome of war and human rights violations. This figure includes 25.9 million having been identified as refugees, and 51% constituting children below 18 years of age which has been documented as the highest figure in a decade.
However, the entire coagulation cascade is dysfunctional, in progressed chronic diabetes and cancer patients.
Elevated body mass index (BMI) has been associated with an increased risk of cancer and has been shown to have a negative impact on survival in patients with breast, prostate, oral cancer, and leukemia. In plasma cell dyscrasias, obesity has not only been shown to be a risk factor for the development of multiple myeloma, but also has been associated with a higher rate of progression from monoclonal gammopathy of unknown significance (MGUS) to multiple myeloma, and if intervened on, has bee
The COVID-19 pandemic has provoked a global, rapid increase of cases due to the high infectivity of the etiological agent, COVID-19 virus. In February 2021, over 110 million confirmed COVID-19 cases with 1 million deaths were reported worldwide (www.who.int).
Lung cancer remains the leading cause of cancer related death in the United States with mortality rates surpassing breast, prostate, brain, and colorectal cancers combined. Recent data shows that susceptibility for both men and women for developing invasive lung and bronchogenic carcinoma peak after the age of 70 years.
Modern Rehabilitation Strategies of Post-Stroke Motor Disfunctions: Functional Electrical Stimulation and Biofeedback-Stabilometric Postural Training
More than 80% of patients after a stroke have limited daily activity due to a complex polymorphic motor deficiency of various nature and severity, which leads to postural disorders (PD) . Because of paresis, develops different changes in the musculoskeletal system (MSS) such as PD, restrictions of movements in the joints, impaired
Pain Outcomes with an Elliptical Regimen (POWER) Study: Identifying the Proper Dosage of Exercise for Therapeutic Effect in Persons with Chronic Back Pain
Low back pain (LBP) is one of the most prevalent conditions that will affect 70-85% of individuals at some point in their life . LBP accounts for 2.3% of all visits to the physician, and is the most common area of the body to experience pain . Exercise has been a mainstay for managing persons with chronic low back pain for almost 40
Progression of Autoantibodies Anti-Gad and Anti-IA2 in Type 1A Diabetics Aged 5 to 21 Years in Cote d’Ivoire
Type 1A diabetes is an autoimmune disease, the final consequence of a slow and gradual process of ß-cell destruction of pancreatic islet Langerhans cells leading to ketoacidosis in the absence of treatment. This destruction of the β cells, responsible for the production of insulin, begins with the initiation of the autoimmune reaction triggered by certain environmental factors and, after several years of evolution, leads to the clinical signs of the disease when the mass of ß cells
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