Volume 2, Issue 3, p68-105
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Risks and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus
Type 1 diabetes (T1D) is associated with microvascular and macrovascular complications.Duration of diabetes, poor glycaemic control, high blood pressure and proteinuria are reported risk factors contributing to the development of diabetes related complications.J Diabetes Clin Res, 2020, Volume 2, Issue 3, p68-74 | DOI: 10.33696/diabetes.1.021
The Impact of the COVID-19 Pandemic Lockdown Measures on Diabetic Retinopathy Services in the East Kent Area of the United Kingdom - A Special Focus on the Pregnant Diabetic
The COVID-19 pandemic has shaped activities across almost all human endeavours. Changes are still ongoing to accommodate all the challenges it poses. The healthcare sector, working closely with governments of nations and regulatory agencies, has helped to control the impact of this highly contagious virus.J Diabetes Clin Res, 2020, Volume 2, Issue 3, p75-77 | DOI: 10.33696/diabetes.1.022
Anti-diabetic Potential of Aqueous Extract of Moringa oleifera, Ocimum gratissimum and Vernonia amygdalina in Alloxan-Induced Diabetic Rats
Diabetes mellitus (DM) is characterized by absolute or relative deficiencies in insulin secretion and insulin action associated with chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. It results from either defect in insulin secretion by the pancreas or inability of the cells to utilize the insulin produced.J Diabetes Clin Res, 2020, Volume 2, Issue 3, p78-85 | DOI: 10.33696/diabetes.1.023
Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device
Chronic, non-healing, or slow to heal wounds present a significant and growing health problem in the United States, with an estimated 6.5 million people affected, at an annual cost of US $20 billion, with the highest risk groups represented by the elderly and the increasing prevalence of lifestyle diseases such as diabetes and obesity.J Diabetes Clin Res, 2020, Volume 2, Issue 3, p86-99 | DOI: 10.33696/diabetes.1.024
Heart failure affects 1-2% of the adult population in developed countries and the lifetime risk of a heart failure diagnosis is 20%. Patients with heart failure have markedly reduced life expectancy, physical capacity and quality of life. One-year all-cause mortality rates for heart failure patients range between 7 and 17% and the yearly hospitalization rate can be as high as 44%.J Diabetes Clin Res, 2020, Volume 2, Issue 3, p100-105 | DOI: 10.33696/diabetes.1.025
While the global COVID-19 pandemic has challenged the entire humanity and health systems, it also triggered researchers to urgently perform clinical trials to assess the safety and efficacy of many agents and modalities to combat COVID-19. As of April 22, over 650 clinical studies have been registered both in USA and internationally. Results from these studies are also coming at a brisk pace in this unprecedented emergency.
Prospective Evaluation of Effect of Metformin on Activation of AMP-activated Protein Kinase (AMPK) and Disease Control in a Sub-group Analysis of Patients with GI Malignancies
Observational studies have demonstrated association of metformin with reduced cancer incidence and mortality in multiple cancer types, including gastrointestinal (GI) malignancies. Anti-neoplastic effects of metformin are believed through many mechanisms including activation of AMP-activated protein kinase, which controls mammalian target of rapamycin (mTOR) growth regulatory pathway.
Low-level Progesterone on the Day of hCG Injection Has No Detrimental Effect on the Pregnancy Outcome after IVF with GnRH-a Protocol: A Retrospective Study
To investigate the effect of low progesterone (P) level on the day of human chorionic gonadotropin (hCG) injection on the outcome of in vitro fertilization (IVF) with GnRH- agonist (GnRH-a) long protocol.
However, the entire coagulation cascade is dysfunctional, in progressed chronic diabetes and cancer patients.
How Traditional Healers Diagnose and Treat Diabetes Mellitus in the Pretoria Mamelodi Area and How Do These Purported Medications Comply with Complementary and Alternative Medicine Regulations
CAM is widely used by patients to treat and prevent certain diseases, providing emotional and physical support . The National Centre for Complementary and Alternative Medicine (NCCAM) defines CAM as a “group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine” .
Worldwide, obesity is a public health concern and a metabolic ailment characterized by excessive adipose tissue accumulation resulting from an imbalance of energy expenditure and energy intake . This disorder is a known risk factor for cardiovascular disease, type 2 diabetes mellitus, dyslipidemia, hypertension, and metabolic
Insulin resistance has been studied extensively at systemic, organ, tissue and cellular and molecular levels. Overnutrition plays an essential role in the development of chronic metabolic diseases such as obesity and type 2 diabetes. For subjects without genetic defects, the development of insulin resistance and type 2 diabetes is a graduate process. How the transition from an insulinsensitive state to an insulin-resistant state occurs, and what the roles of nutrients are in the process have not been fully understood. Here, we try to summarize the current understanding of insulin-regulate gene expression in the liver, and describe a phenomenon of hepatic insulin resistance at gene expression (HIRAGE), which may be linked to overnutrition.
Chronic hypertension is present in 1-2% of pregnant women. Women with chronic hypertension are at an increased risk of maternal and perinatal complications when compared with normotensive women.
Obesity has reached a global epidemic and it predisposes to the development of insulin resistance, type 2 diabetes and related metabolic diseases. Current interventions against obesity and/or type 2 diabetes such as calorie restriction, exercise, genetic manipulations or established pharmacological treatments have not been successful for many patients with obesity and/or type 2 diabetes.
Prevalence of diabetes is increasing. Diabetes is more prevalent in the socially deprived, ethnic minority population (based on continuing rise in elderly population, growing obesity and BME groups). Compliance is a major stumbling block in the management of most long-term conditions including diabetes.
For a long time, it was rare to see a case of cervical pregnancy (CP) throughout the journey in the field of obstetrics. Recently, the circumstances showed dramatic changes and I think not uncommonly every one elsewhere in the field may face this problem to some extent and the CP term strikes his/her ears.
Diabetes mellitus (DM) is an age-related metabolic disorder affecting 347 million people in modern society. Expanding its prevalence beyond developed countries, DM has emerged as a global public health issue associated with a high morbidity and mortality.
Diabetes mellitus is a common metabolic disorder that present with abnormal glucose metabolism. This metabolic disease is prevalent in many countries, worldwide. It is no doubt there might be a chance that diabetes mellitus might co-occur with other medical problems.
Since the declaration of COVID-19 as a pandemic in March 2020 , there have been more than 100 million reported cases of COVID-19 worldwide and more than 2.1 million deaths .
COVID-19 and the Health of Illicit Substance Users: Preliminary Analysis from Illicit Drug Transaction Data
While much attention has been given to how COVID-19 patients are treated (or fail to be treated), the impact of the pandemic on illicit drug users remains largely undiscussed
COVID-19 Rapid Diagnostic Test Results and their Associations with Certain Factors Among the Residents of Balochistan
This paper analyses any possible association of various factors like gender, last COVID-19 PCR test results, BCG Vaccination, Seasonal Flu vaccination, occupation and confirmed case contact history with COVID-19 RDT results of the participants.
Commentary: A Herbal Treatment for Type 2 Diabetes – The Dangers of Adulterated and Falsified Products
In 2018, our group published a letter in The Lancet detailing a case in which a patient had taken a herbal preparation to treat her diabetes . In essence, our laboratory was approached by the treating physician after the patient, a 58 year old lady of south Asian origin with a 30 year history of type 2 diabetes said that, during the previous two years, she had replaced some of her prescribed anti-diabetic medication with a herbal remedy purchased in India.
Adnexal Torsion During the Second Trimester of Pregnancy: Mc Burney Incision and Management Strategy
A 33-year-old pregnant woman at 26 weeks gestation presented with abdominal pain in the right iliac fossa. She had a history of a left ovarian cyst. The current pregnancy was normal. The patient was apyretic.
Obesity, Family History of Diabetes, and Consanguineous Marriages are Risk Factors among Urban Population in South Indian City of Bengaluru
In 2017, approximately 424.9 million adults (age 20- 79 yrs) were affected by diabetes, with 4 million deaths. Global diabetes burden is estimated to increase up to 628.9 million people. Moreover, diabetes care costed approximately $727 billion in 2017.
Pregnancy and Hepatitis B Immunization: A Commentary on Maternal Knowledge and Vertical Transmission Risks
The paper Maternal knowledge of the risk of vertical transmission and offspring acquisition of hepatitis B, recently published in Annals of Hepatology, provides unique insight on a topic not previously studied in the USA. The research paper discusses important topics on maternal hepatitis B infections.
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