Journal of Diabetes and Clinical Research

2020

Volume 2, Issue 3, p68-105

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Mini Review Open Access

Risks and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Rebecca Louise Thomas, Sze May Ng

Type 1 diabetes (T1D) is associated with microvascular and macrovascular complications.Duration of diabetes, poor glycaemic control, high blood pressure and proteinuria are reported risk factors contributing to the development of diabetes related complications.

J Diabetes Clin Res, 2020, Volume 2, Issue 3, p68-74 | DOI: 10.33696/diabetes.1.021

Commentary Open Access

The Impact of the COVID-19 Pandemic Lockdown Measures on Diabetic Retinopathy Services in the East Kent Area of the United Kingdom - A Special Focus on the Pregnant Diabetic

Alamin Alkundi, Rabiu Momoh

The COVID-19 pandemic has shaped activities across almost all human endeavours. Changes are still ongoing to accommodate all the challenges it poses. The healthcare sector, working closely with governments of nations and regulatory agencies, has helped to control the impact of this highly contagious virus.

J Diabetes Clin Res, 2020, Volume 2, Issue 3, p75-77 | DOI: 10.33696/diabetes.1.022

Research Article Open Access

Anti-diabetic Potential of Aqueous Extract of Moringa oleifera, Ocimum gratissimum and Vernonia amygdalina in Alloxan-Induced Diabetic Rats

Ayobami AL, Kade EA, Oladimeji KA, Kehinde S, Gurpreet K

Diabetes mellitus (DM) is characterized by absolute or relative deficiencies in insulin secretion and insulin action associated with chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. It results from either defect in insulin secretion by the pancreas or inability of the cells to utilize the insulin produced.

J Diabetes Clin Res, 2020, Volume 2, Issue 3, p78-85 | DOI: 10.33696/diabetes.1.023

Research Article Open Access

Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device

Robert S. Kellar, Robert B. Diller, Aaron J. Tabor, Dominic D. Dominguez, Robert G. Audet, Tatum A. Bardsley, Alyssa J. Talbert, Nathan D. Cruz, Alison L. Ingraldi, Burt D. Ensley

Chronic, non-healing, or slow to heal wounds present a significant and growing health problem in the United States, with an estimated 6.5 million people affected, at an annual cost of US $20 billion, with the highest risk groups represented by the elderly and the increasing prevalence of lifestyle diseases such as diabetes and obesity.

J Diabetes Clin Res, 2020, Volume 2, Issue 3, p86-99 | DOI: 10.33696/diabetes.1.024

Commentary Open Access

Metformin in Patients with Chronic Heart Failure

Henrik Wiggers, Anders Hostrup Larsen, Lars Køber, Gunnar Gislason, Morten Schou, Mikael Kjær Poulsen, Søren Vraa, Olav Wendelbo Nielsen, Niels Eske Bruun, Morten Bøttcher, Kirsten Vilain Mikkelsen, Jens Lomholdt, Søren Lund Kristensen, Christian Torp-Petersen, Hans Eiskjær, Jacob Møller, Bo Martin Bibby, Christian Hassager, Flemming Hald Steffensen, Jens Refsgaard, Dan Eik Høfsten, Søren Mellemkjær, Finn Gustafsson, Helene Nørrelund

Heart failure affects 1-2% of the adult population in developed countries and the lifetime risk of a heart failure diagnosis is 20%. Patients with heart failure have markedly reduced life expectancy, physical capacity and quality of life. One-year all-cause mortality rates for heart failure patients range between 7 and 17% and the yearly hospitalization rate can be as high as 44%.

J Diabetes Clin Res, 2020, Volume 2, Issue 3, p100-105 | DOI: 10.33696/diabetes.1.025

Submit Manuscript

Recommended Articles

COVID-19 Clinical Research

While the global COVID-19 pandemic has challenged the entire humanity and health systems, it also triggered researchers to urgently perform clinical trials to assess the safety and efficacy of many agents and modalities to combat COVID-19. As of April 22, over 650 clinical studies have been registered both in USA and internationally. Results from these studies are also coming at a brisk pace in this unprecedented emergency.

Prospective Evaluation of Effect of Metformin on Activation of AMP-activated Protein Kinase (AMPK) and Disease Control in a Sub-group Analysis of Patients with GI Malignancies

Observational studies have demonstrated association of metformin with reduced cancer incidence and mortality in multiple cancer types, including gastrointestinal (GI) malignancies. Anti-neoplastic effects of metformin are believed through many mechanisms including activation of AMP-activated protein kinase, which controls mammalian target of rapamycin (mTOR) growth regulatory pathway.

Low-level Progesterone on the Day of hCG Injection Has No Detrimental Effect on the Pregnancy Outcome after IVF with GnRH-a Protocol: A Retrospective Study

Objective: To investigate the effect of low progesterone (P) level on the day of human chorionic gonadotropin (hCG) injection on the outcome of in vitro fertilization (IVF) with GnRH- agonist (GnRH-a) long protocol. Methods: A retrospective study was conducted in a reproductive medicine center of University-affiliated teaching hospital. 1115 women included were divided into two groups according to the P level: Group 1 (233 women with P level ≤ 0.5 ng/ml, and Group 2 (882 women with P level >0.5, ≤ 1.5 ng/ml).

Platelet Hyperactivity and Dysfunction in Diabetes and Cancer

However, the entire coagulation cascade is dysfunctional, in progressed chronic diabetes and cancer patients. Platelets (PLTs) in type 2 diabetic (DT2) involved in Thrombosis and Haemostasis (T&H) of individuals adhere to vascular endothelium and aggregate more voluntarily than those in healthy individuals, as are abnormalities in the microvascular and macrovascular circulations. However it is already known that the circulating PLTs are essential for T&H, inflammation growth factors delivery, regeneration; and knowledge of their function is fundamental to understanding the pathophysiology of vascular disease in diabetes and cancer-related diseases.

How Traditional Healers Diagnose and Treat Diabetes Mellitus in the Pretoria Mamelodi Area and How Do These Purported Medications Comply with Complementary and Alternative Medicine Regulations

In South Africa, new amended regulations required a review of complementary and alternative medicine (CAMs) call-up for registration from November 2013. This impacted traditional healers (THs)’ compliance with the regulatory authorities’ on the good manufacturing practice which in return affected the public’s access to CAMs. This investigation embraces methods, THs use to diagnose and treat diabetes (DM) in Mamelodi. Furthermore, it assesses what their purported medications comprise of.

Energy Expenditure and Nutrition in Neurogenic Obesity following Spinal Cord Injury

Worldwide, obesity is a public health concern and a metabolic ailment characterized by excessive adipose tissue accumulation resulting from an imbalance of energy expenditure and energy intake [1]. This disorder is a known risk factor for cardiovascular disease, type 2 diabetes mellitus, dyslipidemia, hypertension, and metabolic

The Link of Nutrient Fluxes to Hepatic Insulin Resistance at Gene Expression

Results of epidemiological studies show that obesity and type 2 diabetes mellitus have become a public health concern globally, which has substantial health, social and economic impacts. A common characteristic of human obesity and type 2 diabetes is insulin resistance, which a given amount of insulin produces less than normal physiological responses, usually demonstrated as diminished glucose lowering effect of insulin.

Evaluation and Management of chronic Hypertension in Pregnancy

Chronic hypertension is present in 1-2% of pregnant women. Women with chronic hypertension are at an increased risk of maternal and perinatal complications when compared with normotensive women. It is not uncommon for the women with chronic hypertension to present first time during pregnancy and obstetricians are the first one to encounter them during antenatal checkup. Secondary hypertension is often unrecognised and misdiagnosed thus leading to improper treatment with significant risk to the mother and fetus.

Improving Obesity and Insulin Resistance by Targeting Skeletal Muscle MKP-1

Obesity has reached a global epidemic and it predisposes to the development of insulin resistance, type 2 diabetes and related metabolic diseases. Current interventions against obesity and/or type 2 diabetes such as calorie restriction, exercise, genetic manipulations or established pharmacological treatments have not been successful for many patients with obesity and/or type 2 diabetes.

Integrated Community Diabetes Model: Future of Diabetes Services and Way Forward?

Prevalence of diabetes is increasing. Diabetes is more prevalent in the socially deprived, ethnic minority population (based on continuing rise in elderly population, growing obesity and BME groups). Compliance is a major stumbling block in the management of most long-term conditions including diabetes.

Critical Appraisal OF Cervical Pregnancy Management

For a long time, it was rare to see a case of cervical pregnancy (CP) throughout the journey in the field of obstetrics. Recently, the circumstances showed dramatic changes and I think not uncommonly every one elsewhere in the field may face this problem to some extent and the CP term strikes his/her ears. This may be attributed to an actual increase in CP rate that go parallel to widespread application of Assisted Reproduction Techniques (ART) procedures all over the world on one hand and earlier diagnosis owing to liberal utilization and more familiarity with Transvaginal Sonography (TVS) on the other hand.

The Profiling and Role of miRNAs in Diabetes Mellitus

Diabetes mellitus (DM) is an age-related metabolic disorder affecting 347 million people in modern society. Expanding its prevalence beyond developed countries, DM has emerged as a global public health issue associated with a high morbidity and mortality.

Diabetes Mellitus and Dengue

Diabetes mellitus is a common metabolic disorder that present with abnormal glucose metabolism. This metabolic disease is prevalent in many countries, worldwide. It is no doubt there might be a chance that diabetes mellitus might co-occur with other medical problems.

COVID-19 Disease and SARS-CoV-2 Vaccination in Patients with Cancer

Since the declaration of COVID-19 as a pandemic in March 2020, there have been more than 100 million reported cases of COVID-19 worldwide and more than 2.1 million deaths. The purpose of this editorial is to review recent updates regarding COVID-19 disease and SARS-CoV-2 vaccination in cancer patients.

COVID-19 and the Health of Illicit Substance Users: Preliminary Analysis from Illicit Drug Transaction Data

While much attention has been given to how COVID-19 patients are treated (or fail to be treated), the impact of the pandemic on illicit drug users remains largely undiscussed. The consequences of COVID-19 on substance users and on the health care system are exposed.

COVID-19 Rapid Diagnostic Test Results and their Associations with Certain Factors Among the Residents of Balochistan

Background: This paper analyses any possible association of various factors like gender, last COVID-19 PCR test results, BCG Vaccination, Seasonal Flu vaccination, occupation and confirmed case contact history with COVID-19 RDT results of the participants. COVID-19 will soon become endemic in Pakistan, the government should adopt COVID-19 RDT kits for trace, test and quarantine activities.

Commentary: A Herbal Treatment for Type 2 Diabetes – The Dangers of Adulterated and Falsified Products

In 2018, our group published a letter in The Lancet detailing a case in which a patient had taken a herbal preparation to treat her diabetes [1]. In essence, our laboratory was approached by the treating physician after the patient, a 58 year old lady of south Asian origin with a 30 year history of type 2 diabetes said that, during the previous two years, she had replaced some of her prescribed anti-diabetic medication with a herbal remedy purchased in India.

Adnexal Torsion During the Second Trimester of Pregnancy: Mc Burney Incision and Management Strategy

A 33-year-old pregnant woman at 26 weeks gestation presented with abdominal pain in the right iliac fossa. She had a history of a left ovarian cyst. The current pregnancy was normal. The patient was apyretic. Laboratory testing revealed no inflammatory syndrome (leukocyte count of 10G/L and pro c reactive levels were 8 mg/L). In the absence of a diagnosis and given a non-contributory abdominal ultrasound, MRI was requested and revealed a right ovarian teratoma measuring 55 × 73 mm.

Obesity, Family History of Diabetes, and Consanguineous Marriages are Risk Factors among Urban Population in South Indian City of Bengaluru

In 2017, approximately 424.9 million adults (age 20- 79 yrs) were affected by diabetes, with 4 million deaths. Global diabetes burden is estimated to increase up to 628.9 million people. Moreover, diabetes care costed approximately $727 billion in 2017.

Pregnancy and Hepatitis B Immunization: A Commentary on Maternal Knowledge and Vertical Transmission Risks

The paper Maternal knowledge of the risk of vertical transmission and offspring acquisition of hepatitis B, recently published in Annals of Hepatology, provides unique insight on a topic not previously studied in the USA. The research paper discusses important topics on maternal hepatitis B infections.

Journal of Diabetes and Clinical Research

2020

Recommended Articles

About Scientific Archives