Volume 6, Issue 1, p1-23

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Ephrin B1 Regulates Inflammatory Pathways in Retinal Müller Cells

The role of inflammation has been accepted as a factor in the complications of diabetic retinopathy. Discovery of the upstream regulation of these inflammatory factors has remained a challenge. In this study, we explored the actions of ephrin B1 in retinal Müller cells and their actions on inflammatory proteins. We used diabetic human and mouse samples, as well as Müller cells in culture to measure ephrin B1 in Müller cells.

J Diabetes Clin Res, 2024, Volume 6, Issue 1, p1-7 | DOI: 10.33696/diabetes.6.056

A Clinical Case Report: Utility of Amniotic Membrane in Treating a Geriatric Diabetic Patient with a Chronic Pressure Ulcer

Chronic wound closure is the inability for a wound to progress through the standard wound healing stages and timeframe, often stalling during the inflammatory stage. This paper presents a two-year open wound endured by a Native American patient of geriatric age and uncontrolled type II diabetes based on elevated A1c levels. Multiple therapeutic modalities had been attempted to close the wound, without improvement. 

J Diabetes Clin Res, 2024, Volume 6, Issue 1, p8-14 | DOI: 10.33696/diabetes.6.057

Use of Sodium-Glucose Co-transporter-2 Inhibitors after Acute Myocardial Infarction

Whether sodium-glucose co-transporters-2 (SGLT2) inhibitors have beneficial effects on cardiovascular (CV) events and mortality if given within few days from acute myocardial infarction (AMI) is unknown. The DAPA-MI trial (n= 4,107) is the only available study designed to evaluate the impact of administration of dapagliflozin on CV outcomes and mortality if started within 10 days from occurrence of an AMI.

J Diabetes Clin Res, 2024, Volume 6, Issue 1, p15-17 | DOI: 10.33696/diabetes.6.058

Semaglutide for Treatment of Obesity-Related Heart Failure with Preserved Ejection Fraction in Patients with and without Diabetes

The glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide is effective for the treatment of obesity and type 2 diabetes mellitus (T2DM). The purpose of this article is to define the therapeutic role of semaglutide for obesity-related heart failure with preserved ejection fraction (HF-pEF). Methods: Critical review of 2 recent randomized trials, the Subjects with Obesity-related Heart Failure with Preserved Ejection Fraction (STEP-HFpEF) and STEP-HFpEF DM.

J Diabetes Clin Res, 2024, Volume 6, Issue 1, p18-23 | DOI: 10.33696/diabetes.6.059

Recommended Articles

Integrated Community Diabetes Model: Future of Diabetes Services and Way Forward?

Prevalence of diabetes is increasing. Diabetes is more prevalent in the socially deprived, ethnic minority population (based on continuing rise in elderly population, growing obesity and BME groups). Compliance is a major stumbling block in the management of most long-term conditions including diabetes.

Global Syndemic of Metabolic Diseases: Editorial Comments

Editorial is usually a brief article, written by the editor that expresses publishers or journals collective views on a current issue. As an Emeritus Professor, I have taken the liberty of writing these editorial comments, at the invitation of the Editorial Board of the Journal of Diabetes and Clinical Research.

The Profiling and Role of miRNAs in Diabetes Mellitus

Diabetes mellitus (DM) is an age-related metabolic disorder affecting 347 million people in modern society. Expanding its prevalence beyond developed countries, DM has emerged as a global public health issue associated with a high morbidity and mortality.

Diabetes Mellitus and Dengue

Diabetes mellitus is a common metabolic disorder that present with abnormal glucose metabolism. This metabolic disease is prevalent in many countries, worldwide. It is no doubt there might be a chance that diabetes mellitus might co-occur with other medical problems.

The Clinical Utility of Outpatient Continuous Glucose Monitoring in Establishing Insulinoma Diagnosis in a Patient with Impaired Nocturnal Hypoglycemia Awareness

Insulinomas are insulin secreting tumors arising from spontaneous mutations of the ductal, acinar, or islet cells of the pancreas. They are rare, having an incidence of only four cases per million people per year. Patients typically present with fasting hypoglycemia, experiencing neurologic symptoms like confusion, changes in vision, or abnormal behavior and autonomic symptoms like palpitations, diaphoresis, or tremulousness.

Commentary: A Herbal Treatment for Type 2 Diabetes – The Dangers of Adulterated and Falsified Products

In 2018, our group published a letter in The Lancet detailing a case in which a patient had taken a herbal preparation to treat her diabetes [1]. In essence, our laboratory was approached by the treating physician after the patient, a 58 year old lady of south Asian origin with a 30 year history of type 2 diabetes said that, during the previous two years, she had replaced some of her prescribed anti-diabetic medication with a herbal remedy purchased in India.

Obesity, Family History of Diabetes, and Consanguineous Marriages are Risk Factors among Urban Population in South Indian City of Bengaluru

In 2017, approximately 424.9 million adults (age 20- 79 yrs) were affected by diabetes, with 4 million deaths. Global diabetes burden is estimated to increase up to 628.9 million people. Moreover, diabetes care costed approximately $727 billion in 2017.

Altered Peak C-peptide and Fasting Blood Glucose in Children with Autism Spectrum Disorder

ASD refers to a group of complex neurodevelopmental disorders, characterized by deficits in social communication, interaction and demonstrating restricted, repetitive, and stereotyped patterns of behavior. Centers for Disease Control and Prevention forecasted that the prevalence of ASD would be 1 in 45 in USA.

Cut-off Value of Random Blood Glucose among Asian Indians for Preliminary Screening of Persons with Prediabetes and Undetected Type 2 Diabetes Defined by the Glycosylated Haemoglobin Criteria

Type 2 diabetes (T2D) remains undiagnosed for many years in large number of persons living in developing countries. The cost of diagnostic tests and the invasive procedures involved in conventional screening methods remain a major setback to timely testing

The Diabetic Shoulder – A Literature Review

The shoulder complex is composed of three bony structures: the clavicle, scapula, and humerus, which are connected to form three synovial (glenohumeral, acromioclavicular, and sternoclavicular) and two functional (scapulothoracic and subacromial) joints.

Can Vitamin D Supplementation Reduce Insulin Resistance and Hence the Risks of Type 2 Diabetes?

The question of whether or not correction of vitamin D deficiency might reduce the risks of later type 2 diabetes mellitus (T2DM) has been under debate for many decades. The necessity of vitamin D for normal insulin secretion was first identified experimentally in the 1980s.

Investigation of Regimen Adjustment for T2DM Patients Inadequately Controlled on Basal Insulin – Interpretation of the 4200 Study

Epidemiological survey indicated that majority of Chinese T2DM patients were with postprandial hyperglycemia, which may be related to more significant decline of ? cell function and more carbohydrates in dietary structure.

Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina

With increasing rates of obesity, rates of type 2 diabetes and diabetic complications are expected to rise exponentially over the next few decades (American Diabetic Association). A key feature of type 2 diabetes is a resistance to insulin. Insulin signaling is key to a number of physiological processes, including glucose metabolism, cell growth, general gene expression, and apoptosis.

Perivascular Adipose Tissue: Quantitative Analysis by Morphometry and Stereology in Rodents

Virtually all arteries, except brain arteries, are surrounded by a significant amount of perivascular adipose tissue (PVAT). It was thought that the PVAT was only responsible for the mechanical protection of vessels against neighboring tissues during contraction.

Identification of Risk Markers for Poorly Controlled Type 2 Diabetes Mellitus: A Retrospective Cross-Sectional Study with Focus on Quality Assurance Based on Real World Data

Type 2 diabetes mellitus (T2DM) is a metabolic disease defined by hyperglycemia. If not treated, chronic and even short periods (i.e. weeks) of undesirable hyperglycemia increases the risk for developing diabetic microvascular complications such as retinopathy, neuropathy, nephropathy, foot ulcers and amputations, and macrovascular complications such as cardiovascular disease including stroke

Clinician's Review of Thyroid and Parathyroid Disease

The presentation of thyroid disease is on a spectrum with clinical presentations and disease severity ranging from subclinical to critical. The principal function of the thyroid gland is to produce T3 (triiodothyronine) and T4 (thyroxine). The hypothalamus and pituitary glands release thyrotropin releasing hormone (TRH) and thyroid stimulating hormone (TSH) respectively, and this stimulates the release of T3 and T4 directly from the thyroid gland.

Neuromotor Impairment, Hearing Loss and Blindness in a Preclinical Mouse Model of Charcot Marie-Tooth Disorder

In the peripheral nervous system (PNS), Schwann cells (SCs) are responsible for myelin production, which contributes to axonal protection and allows for efficient action potential transmission. Unfortunately, acquired and hereditary demyelinating diseases of the PNS are numerous and affect an increasing number of people.

Commentary on – ISPAD Clinical Practice Consensus Guidelines: Fasting during Ramadan by Young People with Diabetes

This is a commentary on the recent work by our group on fasting during Ramadan by young people with diabetes which was published as ISPAD Clinical Practice Consensus Guidelines. In this commentary, themes of selected studies published following the guidelines release are highlighted.

Hyperglycemia and diabetes in hospitalized patients with COVID-19

The prevalence of diabetes in COVID-19 patients ranges from 5.3% to 58% representing the second comorbidity after hypertension. However, when adjusted for age, diabetes prevalence among COVID-19 patients is similar to its prevalence in the general population.

Resveratrol Treatment Reduces Neuromotor Impairment and Hearing Loss in a Mouse Model of Diabetic Neuropathy and Nerve Injury

In the peripheral nervous system (PNS), Schwann cells (SCs) are responsible for myelin production, which contributes to axonal protection and allows for efficient action potential transmission. Unfortunately, acquired and hereditary demyelinating diseases of the PNS are numerous and affect an increasing number of people.