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2022

Volume 4, Issue 2, p33-70

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Higher Frequency and Poor Prognosis with COVID-19 Associated Cytokine Storm among Cancer Patients: Between Two Fires

At the end of 2019, the world faced a new disease, COVID-19 caused by SARS-Cov-2 and became a pandemic within few weeks. The fact that COVID-19 spreads very quickly and has
significant morbidity and mortality had devastating effects all over the world.

J Cancer Immunol, 2022, Volume 4, Issue 2, p33-42 | DOI: 10.33696/cancerimmunol.4.063

Performance of the Tyrer-Cuzick 8 Breast Cancer Risk Model Across Races: A Review

The Tyrer-Cuzick (TC) model is a breast cancer risk assessment tool that provides women with their risk of developing breast cancer based on genetic and personal factors. The most recent version of the TC model, TC8, is the first version to include breast density as a risk factor for breast cancer.

J Cancer Immunol, 2022, Volume 4, Issue 2, p47-51 | DOI: 10.33696/cancerimmunol.4.065

Clutch Control: Changing the Speed and Direction of CAR-T Cell Therapy

The adoptive transfer of T cells expressing chimeric antigen receptors (CAR-T cells) has revolutionized the treatment of hematological malignancies, providing unmatched clinical responses in adults and children with relapsed or refractory B cell malignancies.

J Cancer Immunol, 2022, Volume 4, Issue 2, p52-59 | DOI: 10.33696/cancerimmunol.4.066

Molecular Iodine Misconceptions: A Novel Formulation Approach to Topical Iodine

My team of chemists have formulated molecular iodine (I2) so it can be studied independent of other iodine species.The initial impetus for this effort was to allow for a higher concentration of biocidal I2 that would not evaporate into the atmosphere when applied to skin.

J Cancer Immunol, 2022, Volume 4, Issue 2, p60-64 | DOI: 10.33696/cancerimmunol.4.067

A Surprising Benefit of Cysteine Capping for Antibody Drug Conjugates

Antibody-drug conjugates (ADCs), combining the best features of monoclonal antibodies and small molecule drugs, are considered the “guided missiles” for cancer therapy, with eleven FDA-approved products. Yet the ADC modality still presents a huge challenge to drug developers, especially for targeting tumors with low abundance and/or heterogeneity of tumor-associated antigens.

J Cancer Immunol, 2022, Volume 4, Issue 2, p65-70 | DOI: 10.33696/cancerimmunol.4.068

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