Appropriate medicinal drugs can save life of any patientat risk with high mortality and morbidity. All ongoingcosts and benefits are covered mainly by the health insurance, the pharmaceutical, and alternative medicine industry. Recently economic problems affect Patients-Related Care/-Cure and Medical Approach (PRCCMA). It is becoming obvious that lack of Global Scientific Standard Procedures (GSSP), somehow a defective system of support by local governmental organizations, profits and benefits, and dramatic decrease in the appropriate research funds; have affected either ‘the choices’ of patients or of the different (multidisciplinary) medics to get right drugs for their treatment strategies and ongoing disease, shockingly. Subsequently, in 21^st century the PRCCMA is going toward cheaper and cheapest, and not better and best qualified medicine. Both patients and authorities are looking for good qualified (para-) medics, remarkably. How with cheapest drugs and alternative medicine could a physician cure a cancer patient is the main challenge in this century. On the other hand, another important issue is still the relationship between the main cause of the in-hospital mortality and morbidity rate and applied drugs and their side effects, which they are not studied and being elucidated completely [1-3]. Human Blood Platelets (HBP) are lifesaving a-nucleated blood cells, which are playing pivotal rule in bleedings and/or thrombosis-related disorders. HBP’s easily being affected after anti-coagulants/anti-platelet (anti-CP) drugs intake. Because of different underlying cardiovascular and or Hemato-oncological diseases, physicians prescribe different anti-CP to manage certain disease progression and monitor treatments and/or side effects. After certain unknown modern drugs platelet disorders lead to defectsin primary haemostasis, and have indications dissimilar from coagulation factor proteins deficiencies (disorders of secondary haemostasis). There are raising evidences that platelets dis-functioning properties are involved in the cancer metastasis, however [1-4]. The main bleeding disorders (massive and uncontrolled leakage of the certain damaged vasculatures), and thrombosis (sudden massive clot forming due to thrombocyte hyperactivity defects) are directly correlated to HBPs dysfunction and hyperactivities [5]. These afore-mentioned processes are strictly regulated by multifactorial dissimilar processes [3-5]. Hypothetically it would be great if we could monitor all kinds of exogenous effects of drugs on HBPs’ pathophysiology, timely. In 21^st century different economic-based reasons resulted in quick approval of unknown (biological) drugs and without any validation restrictions. The FDA approved some biological drugs for production, which almost none of these novel drugs got time to follow standard validation procedures, in my view. In one hand, from recent (unpublished) data could be seen that sudden death increased in patients and some randomised subjects between 30 to 35 y old males, significantly. On the other hand, the FDA approves in a rap tempo any unknown biological (alternative) drugs, which might have a miniscule effect on some untreatable diseases. Unfortunately, catastrophic effects of approvals cause un-comprehensive medical practices based on economic-based choices. In my view, all Medici and Governments should be concerned about ongoing progressions in drugs development and public healthpolicy. One is observing a bad progression toward medicinal choices, which would be made on selection bias and economic-based condition of patients. Recall, all side effects in patients were generated after first pharmaceutical applications.