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Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

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Circulating Cell-Free RNA: A New Perspective for Endometrial Cancer

In order to implement the knowledge of cancer to monitor its evolution and setting, in the last decade, new minimally invasive and repeatable samples collection have been developed such as liquid biopsy.

Looking Ahead: Interesting Developments in Menopause Management

There are many exciting developments in the field of midlife women’s health which explain how menopause symptoms, particularly hot flashes, may be an important vital sign and predictor of future health status

Preliminary Study Assessing the Efficiency of a New Singleuse Obstetrical Vacuum Device: Icup2®

A national perinatal survey in France in 2016 showed that 12.2% of women have instrumentally assisted vaginal births with vacuum extraction used in 49.8% of cases, making it the most frequently used form of obstetrical assistance.

Ultrasound in Obstetrics and Gynecology

We are witnessing the evolution of the diagnostic imaging that is rapidly becoming available to Women’s Health physicians (OB/GYN’s), enabling the use of technology to augment our ability to medically palpate on examination of the patient, to identify conditions which we were unable to appreciate a short time ago.

Early Onset Fetal Growth Restriction: Does Path to Diagnosis Impact Outcomes and Pathology?

The etiology of fetal growth restriction is rooted in inadequate maternal-placental vascular malperfusion (MVM) of the placenta. Risk factors for MVM are broad and include maternal, fetal, and placental antecedent determinants.

Family Planning Laboratory Review of Factors Affecting the Choice of Contraceptive Methods in Three Teenagers' Populations in Thrace, Greece

Contraception encompasses the concept of avoiding a pregnancy, and is aimed at women of reproductive age who, although are sexually active, do not want to achieve any pregnancy at their option fertility preservation and family planning

Low-level Progesterone on the Day of hCG Injection Has No Detrimental Effect on the Pregnancy Outcome after IVF with GnRH-a Protocol: A Retrospective Study

To investigate the effect of low progesterone (P) level on the day of human chorionic gonadotropin (hCG) injection on the outcome of in vitro fertilization (IVF) with GnRH- agonist (GnRH-a) long protocol.

Impact of Estradiol Supplementation during Luteal Phase Support on the In vitro Fertilization Clinical Outcome: Systematic Review and Meta-Analysis

At present, progesterone administration is widely used. There is no agreement on whether estradiol (E2) addition should be supplement to progesterone (P) as luteal phase support (LPS).

Intrauterine Device Embedment Resulting in Its Fracture: A Case Series

As gynecologic providers continue to provide intrauterine devices (IUDs) for long-acting reversable contraception (LARC) with insertion of those devices, the associated complication rate needs to be well-understood, so that patients can make properly informed shared healthcare decisions.

Recommendation of Tetanus Toxoid Vaccination for Pregnant Females in a Country that Achieved Elimination of Maternal and Neonatal Tetanus. A commentary on the Study: Knowledge and Health Beliefs of Reproductive-age Women in Alexandria about Tetanus Toxoid Immunization

The study “knowledge and health beliefs of reproductive-age women in Alexandria about tetanus toxoid immunization” has shed a new light on the attitude of obstetricians in Alexandria (Egypt) towards recommending tetanus toxoid vaccination to pregnant females.

The Safety of High Dose Labetalol in the Pregnant Population

Medical management of hypertension in pregnancy is indicated for severe range blood pressures. This is diagnosed with either systolic blood pressure (SBP) ≥ 160 mm Hg and/or diastolic blood pressure (DBP) ≥110 mm Hg on two occasions at least 4 hours apart. When this diagnosis is established, fast-acting anti-hypertensive medications can be utilized for acutely severe range blood pressures.

Evaluation and Management of chronic Hypertension in Pregnancy

Chronic hypertension is present in 1-2% of pregnant women. Women with chronic hypertension are at an increased risk of maternal and perinatal complications when compared with normotensive women.

Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery in Stage 1B2 Cervical Cancer

In 2020 we published a series of 18 patients who underwent neoadjuvant chemotherapy (NACT) and vaginal radical trachelectomy (VRT) as a fertility sparing alternative in stage 1B2 cervical cancer.

Gene Therapy for Sickle Cell Disease: Start of a New Era

This manuscript reviews treatment of Sickle Cell disease over time. The application of allogeneic stem cells proved the sickle cell disease could be permanently corrected and cured but limited to those with a compatible donor.

Challenges Regarding the Management of Gynecological and Obstetric Complications in Women with Inherited Factor XIII Deficiency

The medical care of patients with inherited bleeding disorders requires a greater understanding and attention, especially in women who can be exposed to specific hemorrhagic complications such as menorrhagia or complications during pregnancies and deliveries.

Practical Considerations Regarding Recommendations for an Educational Program in Robot Assisted Gynaecological Surgery

Robot assisted gynaecological surgery is exponentially expanding its field and gynaecologists need to be prepared to implement this new approach in clinical practice.

Critical Appraisal OF Cervical Pregnancy Management

For a long time, it was rare to see a case of cervical pregnancy (CP) throughout the journey in the field of obstetrics. Recently, the circumstances showed dramatic changes and I think not uncommonly every one elsewhere in the field may face this problem to some extent and the CP term strikes his/her ears.

After Surgical Menopause, Should Menopausal Hormonal Therapy Started Only Before the Age of 45 Years?

The published study Compliance and health consequences of menopausal hormonal therapy after surgical menopause: A retrospective study in Thailand showed that menopausal hormonal therapy soon after bilateral oophorectomy before the age of natural menopause in Thailand

The Role of Anemia in Term and Preterm Pregnancies: Evidence from the Brazilian Multicenter Study on Preterm Birth (EMIP)

Evaluate the prevalence of anemia in term and preterm pregnancies and compare maternal and perinatal outcomes among groups.

Strong Association Between Placental Pathology and Second-trimester Miscarriage

The survival probability of early human conceptions is very low. At least 73% of natural single conceptions have no real chance of surviving six weeks of gestation [1]. After six weeks, survival rates improve rapidly as 90% of the remainder will survive to term.