Letter to the Editor Open Access
Volume 6 | Issue 3 | DOI: https://doi.org/10.33696/Gynaecology.6.093
Methotrexate Treatment of Ectopic Pregnancy
Elliot M. Levine1,*
- 1Rosalind Franklin University, Obstetrics and Gynecology, United States
Corresponding Author
Elliot M. Levine, elliot.levine@rosalindfranklin.edu
Received Date: November 23, 2025
Accepted Date: December 03, 2025
Levine EM. Methotrexate Treatment of Ectopic Pregnancy. Arch Obstet Gynecol. 2025;6(3):95.
Copyright: © Levine EM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recommended Articles
Ectopic Pregnancy: Vascularity Index as a Novel Diagnostic Criterion
Since the medical management of ectopic pregnancy (EP) was introduced by Dr. Steven Ory, and published in 1986 in the American Journal of Obstetrics and Gynecology, diagnostic criteria have been established to predict its successful medical treatment with methotrexate (MTX), including its maximum diameter (MaxDia), its associated human chorionic gonadotropin (hCG) level, and whether there was identified cardiac motion (CM).
Can the Systemic Immune Inflammation Index Predict the Treatment of Ectopic Pregnancy?
Objective: The aim of this study was to predict the selection of treatment for ectopic pregnancy (EP) using the values of platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) and systemic immune inflammation index (SII) obtained from hematological parameters routinely used in clinical practice.
The Effectiveness of Methotrexate in Hemodynamically Stable Women with Tubal Ectopic Pregnancy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background: Ectopic pregnancy (EP) is a leading cause of acute abdominal pain in gynecology. Most women with tubal EP present hemodynamically stable, making non-surgical therapy a viable option. This study aimed to evaluate the effectiveness and safety of methotrexate (MTX) regimens in this population. Methods: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs). A comprehensive search of PubMed, Cochrane Library, Embase, LILACS, SciELO, and CINAHL was conducted from database inception to April 2025.
Methotrexate Treatment of Ectopic Pregnancy
In their detailed review of randomized controlled trials (RCTs) of intact tubal ectopic pregnancies (EPs) treated with methotrexate (MTX), the benefit of single dose MTX treatment was made clear,recognizing the easily administered low-cost treatment as having an 81% success rate.