Loading

logo

Journal of Experimental Neurology

ISSN: 2692-2819

2024

Volume 5, Issue 2, p42-106

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Review Article Open Access

Cerebrovascular Dysfunction in Alzheimer’s Disease and Transgenic Rodent Models

Xing Fang, Fan Fan, Jane J Border, Richard J. Roman

Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementia (ADRD) are the primary causes of dementia that has a devastating effect on the quality of life and is a tremendous economic burden on the healthcare system. The accumulation of extracellular beta-amyloid (Aβ) plaques and intracellular hyperphosphorylated tau-containing neurofibrillary tangles (NFTs) in the brain are the hallmarks of AD.

J Exp Neurol, 2024, Volume 5, Issue 2, p42-64 | DOI: 10.33696/Neurol.5.087
Review Article Open Access

Treatment of Sleep Disorders in Children with Atopic Dermatitis: What's New?

Maria Beatriz Tavares Camacho Pereira, Larissa Toledo de Lima Duarte Souza, Dennis de Carvalho Ferreira, Juliany Estefan

Atopic dermatitis (AD), also known as atopic eczema, is a chronic and inflammatory disease caused by an interaction of genetic, immunological, and environmental factors. It is characterized by skin lesions and itching and progresses with periods of improvement and worsening.

J Exp Neurol, 2024, Volume 5, Issue 2, p65-72 | DOI: 10.33696/Neurol.5.088
Commentary Open Access

Homeostatic Synaptic Plasticity may be Targeted for the Prevention of Post-Stroke Epilepsy

Yadav Adhikari, Xiaoming Jin

Stroke is the most common cause of acquired epilepsy, with up to 30 percent of stroke survivors developing epilepsy over time. However, the mechanisms leading to neuronal hyperexcitability and epilepsy in stroke survivors are not fully understood. In a recently published work, we demonstrate that ischemic stroke induces homeostatic plasticity regulation in the surviving neurons in the peri-stroke area.

J Exp Neurol, 2024, Volume 5, Issue 2, p73-78 | DOI: 10.33696/Neurol.5.089
Review Article Open Access

The Role of Transcranial-Color-Doppler in the Management of Basilar Artery Stenosis: Case Series and Systematic Review of Literature

Marta Filidei, Chiara Di Schino, Massimiliano Allegritti, Danilo Costanti, Ilaria Morandini, Alice Riva, Giovanna Viticchi, Carlo Colosimo, Stefano Caproni

Managing vertebrobasilar (VB) stroke, particularly basilar artery occlusion (BAO), presents challenges due to diverse clinical presentations and intricate diagnostics, risking delays in acute-phase reperfusion therapies. The diagnostic complexities of VB stroke prompt questions about whether presentation tempo influences outcomes. For non-urgent cases of basilar artery stenosis (BAS) lacking guidelines, clinical management becomes case-dependent.

J Exp Neurol, 2024, Volume 5, Issue 2, p79-94 | DOI: 10.33696/Neurol.5.090
Review Article Open Access

Hashimoto’s Encephalopathy: A Review

Arvind Ramesh, Arun Swaminathan

The condition "Hashimoto's encephalopathy" (HE) refers to a cerebral dysfunction syndrome with elevated antithyroid peroxidase antibody titers that is thought to have an autoimmune cause. Similar to autoimmune thyroid illness, women are more likely than men to develop HE. It has been documented in adult, geriatric, and pediatric populations worldwide. The clinical appearance may be recurrent and remitting, with myriad symptoms involving myoclonus, seizures, episodes resembling strokes, cognitive deterioration, and neuropsychiatric symptoms. Clinically and biochemically, thyroid function is often normal.

J Exp Neurol, 2024, Volume 5, Issue 2, p95-106 | DOI: 10.33696/Neurol.5.093
Submit Manuscript

Recommended Articles

Multidisciplinary Acute Care of Central Retinal Artery Occlusion with a Stroke Paradigm: A Call to Action

Central retinal artery occlusion (CRAO) is a painless ophthalmologic emergency with potential for irreversible vision loss. Similar to ischemic stroke, CRAO occurs when there is sudden obstruction of the central retinal artery, leading to ischemic injury to the retina and subsequent cell death. Continuous occlusion and ischemia of the retina progresses to permanent damage to retinal cells and loss of vision.

Modern Rehabilitation Strategies of Post-Stroke Motor Disfunctions: Functional Electrical Stimulation and Biofeedback-Stabilometric Postural Training

More than 80% of patients after a stroke have limited daily activity due to a complex polymorphic motor deficiency of various nature and severity, which leads to postural disorders (PD) [1]. Because of paresis, develops different changes in the musculoskeletal system (MSS) such as PD, restrictions of movements in the joints, impaired

No Studies in Stroke Regarding Brain fMRI Activity and Pelvic Floor Muscle Training/Activation - Only Studies in Non-stroke Population: A Review of Neuroimaging Studies

Neurogenic lower urinary tract dysfunction (NLUTD) is highly prevalent in poststroke patients, leading to major impact on the quality of life (QoL) and healthcare resources. Pelvic floor muscle training (PFMT) has, over the past two decades, been recommended as first-line treatment for neurologically healthy patients with lower urinary tract symptoms (LUTS). 

Comparative Effect of Levetiracetam and Carbamazepine versus Levetiracetam and Sodium Valproate on Seizure Frequency in Patients with Epilepsy

Epilepsy involves one or a group of chronic disorders in which seizures recur unprovoked and unpredicted. Epidemiological studies in the United States estimate that about 2 million people have epilepsy. About 44 cases per 100,000 people annually are diagnosed with epilepsy, which is about 1% in the United States at the age of about

Epilepsy in Neurodegenerative Disease: A Commentary

Case Summary - We published a case report of a 22-year-old woman who presented to our university hospital with encephalopathy and left hemiparesis of a few weeks duration. 

To Stick or Not to Stick? Scalp and Intracranial EEG Evaluation Both Help Achieve Good Surgical and Neuropsychiatric Outcomes in Epilepsy Surgery up to 20 Years Post-Surgery

Epilepsy has a worldwide prevalence of about 50 million [1]. Seizure medications provide adequate control in two thirds of these patients but about a third are refractory to multiple medications and need surgery or other treatments [2].

Cathepsin D: A Candidate Link between Amyloid β-protein and Tauopathy in Alzheimer Disease

Alzheimer disease (AD) is a debilitating neurodegenerative disorder characterized by extracellular deposition of the amyloid β-protein (Aβ) and intraneuronal accumulation of the microtubule-associated protein, tau

Atrial Fibrillation, Atrial Cardiopathy and Cryptogenic Strokes

Cryptogenic stroke (CS) refers to the cerebral infarcts for which no definite cause is identified after adequate diagnostic evaluation. It accounts for 10-15% of all
strokes. Most of the cryptogenic strokes are embolicappearing non-lacunar infarcts based on the radiographic pattern. 

Commentary: Use of BACTRAC Proteomic Database-Uromodulin Protein Expression During Ischemic Stroke

Uromodulin (UMOD) is a glycoprotein expressed by the epithelial cells of the thick ascending limb of Henle’s loop in the kidney. Research has shown that increased uromodulin expression may be associated with lower risk of cardiovascular disease in adults.

Stroke, Oxygen and Prehospital Care: A Commentary on Current Treatments and Opportunities for Improvement

Stroke is a common and very serious illness where timely evaluation and intervention can have dramatic effects on patient outcomes.

Preventing Stroke in Sickle Cell Disease: 2021. The Role of Transcranial Doppler Ultrasound (TCD) When the Use of Transfusion is Problematic

While TCD is an indicator of risk, not a biopsy diagnosis (such as proof of cancer), at some point in the velocity spectrum the high velocity detected by TCD reaches what many believe is an unacceptable risk of stroke.

Commentary – HIV-Induced Extracranial Carotid Ectasia and Stroke

HIV is a known risk factor for both ischemic and hemorrhagic stroke. Even with the widespread use of antiretroviral therapy, stroke incidence is higher in patients with HIV compared to non-HIV control subjects.

Glucose Metabolism is a Better Marker for Predicting Clinical Alzheimer’s Disease than Amyloid or Tau

Alzheimer’s disease (AD) research has long been dominated with communications regarding the amyloid hypothesis and targeting amyloid clearance through pharmacological therapies from the brain [1]. 

Sleep Disturbances are a Significant Predictor of Chikungunya Arthritis Flare Severity

Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes that causes debilitating arthritis. In a cohort of 500 Colombian patients, one quarter reported joint pain 20 months after infection, and further, 1 out of 8 had joint pain three years after infection.

Determination of Teeth and Arch Size Using Cone-Beam Computed Tomography in an Iranian Population

Teeth and arch size determination is an important factor in dentistry and forensic medicine. Evidence shows that cone-beam computed tomography (CBCT) is a highly accurate tool for the measurement of mesiodistal tooth width and arch dimensions. This study aimed to assess the teeth and arch dimensions of males and females on CBCT images of patients presenting to the Radiology Department of Tabriz School of Dentistry.

Body Iron Overload is a Determining Factor in Brain Damage in Acute Ischemic Stroke

Stroke is the second largest cause of death worldwide, with a world annual mortality incidence of about 5.5 million people, and it is also the leading cause of disability worldwide with 50% of survivors being chronically disabled.

Stroke and Visual Loss in a Young Girl with Dengue Fever – Report of a Case and a Mini Review

The case of a young girl with Dengue fever presenting with seizures and bilateral visual loss is presented. At the time of presentation, she had right hemiplegia and dysarthria but was not dysphasic. Fundoscopy revealed presence of macular and disc oedema in the right eye and vitreous haemorrhage in the left eye.

Therapeutic Effectiveness of Brain Computer Interfaces in Stroke Patients: A Systematic Review

Brain-computer interfaces (BCIs) are a rapidly advancing field which utilizes brain activity to control external devices for a myriad of functions, including the restoration of motor function. Clinically, BCIs have been especially impactful in patients who suffer from stroke-mediated damage. However, due to the rapid advancement in the field, there is a lack of accepted standards of practice.

Responsive Neurostimulation for Management of Refractory Precuneus Onset Epilepsy: A Case Report

Posterior quadrant epilepsy is relatively uncommon and refractory seizures from these regions are difficult to diagnose and manage. A 28-year-old woman presented for evaluation of her seizures. Scalp Electroencephalogram (EEG) showed seizures with independent onset over the right posterior and left anterior regions.

Immunologic Implications for Stroke Recovery: Unveiling the Role of the Immune System in Pathogenesis, Neurorepair, and Rehabilitation

Stroke is a debilitating neurologic condition characterized by an interruption or complete blockage of blood flow to certain areas of the brain. While the primary injury occurs at the time of the initial ischemic event or hemorrhage, secondary injury mechanisms contribute to neuroinflammation, disruption of the blood-brain barrier (BBB), excitotoxicity, and cerebral edema in the days and hours after stroke.

About Scientific Archives

Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.

Read More