Journal of Diabetes and Clinical Research

Research Article Open Access

A Customized Artificial Pancreas System with Neural Network based Model Predictive Control for Type 1 Diabetic Rats

Omer Batuhan Kirilmaz, Masoud Mahdavi, Hoo Sang Ko, H. Felix Lee, Sarah Park, Guim Kwon

Advances in sensor and computing technology have enabled researchers to develop artificial pancreas systems (APS) that can mimic the glucose regulation function of a healthy pancreas to treat type 1 diabetes mellitus (T1DM). APS use a continuous glucose monitor (CGM) sensor to read the latest blood glucose level (BGL).

Commentary Open Access

Dysregulation of the OGF-OGFr Pathway and Associated Diabetic Complications

Patricia J. McLaughlin, Joseph W. Sassani, Ian S. Zagon

Diabetes is a major healthcare concern worldwide. In addition to the financial burden estimated at $760 billion, the human suffering related to complications of diabetes as well as the disease itself are immense. Complications associated with diabetes affect both men and women, but there is a higher incidence reported in the aging population, women, and people of color.

Commentary Open Access

CERT-Dependent Ceramide Transport, A Crucial Process in Cells

Cécile L. Bandet, Eric Hajduch

In mammalian cells, ceramides are central lipids in sphingolipid metabolism and serve both as signaling lipids and as precursors for other bioactive sphingolipids, ranging from complex glycosphingolipids to “simpler” lipids such as ceramide-1-phosphate, sphingomyelin (SM), sphingosine and sphingosine-1-phosphate (S1P).

Commentary Open Access

Adapting the Escape Room to Engage Learners Two Ways During COVID-19

Laura Wynn

When creating the project, “An Escape Room Simulation Focused on Renal-Impairment for Prelicensure Nursing Students” [1] the author’s goal was to increase positive health outcomes for patients with acute kidney injury (AKI). AKI is complicated, but nurses who can help identify those at risk for the disorder and help initiate early treatment can improve patients’ results.

Commentary Open Access

Can Monoclonal Antibodies against CGRP Offer New Treatment Options for Type 2 Diabetes?

Celine E Riera

The neuropeptide Calcitonin Gene-Related Peptide (CGRP) is a 37-amino acid peptide, with a wide-range of biological activities including vasodilation, neurogenic inflammation, immune function and hypertension. In addition to these various roles, it has also been heavily implicated in metabolic disease, with roles in feeding, energy dissipation processes and pancreatic β-cell insulin secretion.

Research Article Open Access

Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device

Robert S. Kellar, Robert B. Diller, Aaron J. Tabor, Dominic D. Dominguez, Robert G. Audet, Tatum A. Bardsley, Alyssa J. Talbert, Nathan D. Cruz, Alison L. Ingraldi, Burt D. Ensley

Chronic, non-healing, or slow to heal wounds present a significant and growing health problem in the United States, with an estimated 6.5 million people affected, at an annual cost of US $20 billion, with the highest risk groups represented by the elderly and the increasing prevalence of lifestyle diseases such as diabetes and obesity.

Mini Review Open Access

Risks and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Rebecca Louise Thomas, Sze May Ng

Type 1 diabetes (T1D) is associated with microvascular and macrovascular complications.Duration of diabetes, poor glycaemic control, high blood pressure and proteinuria are reported risk factors contributing to the development of diabetes related complications.

Research Article Open Access

Resveratrol Treatment Reduces Neuromotor Impairment and Hearing Loss in a Mouse Model of Diabetic Neuropathy and Nerve Injury

Sergio Gonzalez-Gonzalez, Chantal Cazevieille, Bastien Caumes

In the peripheral nervous system (PNS), Schwann cells (SCs) are responsible for myelin production, which contributes to axonal protection and allows for efficient action potential transmission. Unfortunately, acquired and hereditary demyelinating diseases of the PNS are numerous and affect an increasing number of people.

Research Article Open Access

Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina

Youde Jiang, Li Liu, Hainan Li, Jie-Mei Wang, Jena J. Steinle

With increasing rates of obesity, rates of type 2 diabetes and diabetic complications are expected to rise exponentially over the next few decades (American Diabetic Association). A key feature of type 2 diabetes is a resistance to insulin. Insulin signaling is key to a number of physiological processes, including glucose metabolism, cell growth, general gene expression, and apoptosis.

Commentary Open Access

Can Vitamin D Supplementation Reduce Insulin Resistance and Hence the Risks of Type 2 Diabetes?

Barbara J Boucher

The question of whether or not correction of vitamin D deficiency might reduce the risks of later type 2 diabetes mellitus (T2DM) has been under debate for many decades. The necessity of vitamin D for normal insulin secretion was first identified experimentally in the 1980s.

Short Communication Open Access

Cut-off Value of Random Blood Glucose among Asian Indians for Preliminary Screening of Persons with Prediabetes and Undetected Type 2 Diabetes Defined by the Glycosylated Haemoglobin Criteria

Priscilla Susairaj, Chamukuttan Snehalatha, Arun Raghavan, Arun Nanditha, Ramachandran Vinitha, Krishnamoorthy Satheesh, Desmond G Johnston, Nicholas J Wareham, Ambady Ramachandran

Type 2 diabetes (T2D) remains undiagnosed for many years in large number of persons living in developing countries. The cost of diagnostic tests and the invasive procedures involved in conventional screening methods remain a major setback to timely testing

Research Article Open Access

Altered Peak C-peptide and Fasting Blood Glucose in Children with Autism Spectrum Disorder

Mengxiang Zhang, Rui Ding, Zuqun Wang, Juan Zhang, Jing Liu, Juan Wang

ASD refers to a group of complex neurodevelopmental disorders, characterized by deficits in social communication, interaction and demonstrating restricted, repetitive, and stereotyped patterns of behavior. Centers for Disease Control and Prevention forecasted that the prevalence of ASD would be 1 in 45 in USA.

Review Article Open Access

The Profiling and Role of miRNAs in Diabetes Mellitus

Michael Kim, Xiaokan Zhang

Diabetes mellitus (DM) is an age-related metabolic disorder affecting 347 million people in modern society. Expanding its prevalence beyond developed countries, DM has emerged as a global public health issue associated with a high morbidity and mortality.

Editorial Open Access

Global Syndemic of Metabolic Diseases: Editorial Comments

Gundu H. R. Rao

Editorial is usually a brief article, written by the editor that expresses publishers or journals collective views on a current issue. As an Emeritus Professor, I have taken the liberty of writing these editorial comments, at the invitation of the Editorial Board of the Journal of Diabetes and Clinical Research.