Schwann cells produce myelin sheath around peripheral nerve axons. Myelination is critical for rapid propagation of action potentials, as illustrated by the large number of acquired and hereditary peripheral neuropathies, such as diabetic neuropathy or Charcot-Marie-Tooth diseases, that are commonly associated with a process of demyelination. Peripheral neuropathy is a major complication of diabetes, and the pathomechanism of the disease remains poorly studied. Here, we studied the progressive peripheral neurodegeneration characterized by a demyelinating process and hearing impairment observed in the diabetic mouse model db/db and we determined the efficacy of daily resveratrol (RSV) treatment in the neuromotor impairment and hearing loss. Moreover, we previously validated the efficacy of resveratrol treatment in a fast screening model of peripheral neuropathy, the sciatic nerve crush model. Our results confirm that these mice represent a robust and validated model to study the peripheral neuropathy induced by diabetes and open a potential opportunity to develop new pharmacological candidates targeting diabetic neuropathy.

Diabetic, Diabetic neuropathy, Nerve injury