Journal of Cellular Immunology

Research Article Open Access

Human Gray and White Matter Metabolomics to Differentiate APOE and Stage Dependent Changes in Alzheimer’s Disease

Tyler C. Hammond , Xin Xing , Lucy M. Yanckello , Arnold Stromberg , Ya-Hsuan Chang , Peter T. Nelson , Ai-Ling Lin

Alzheimer’s disease (AD) is a leading cause of death and morbidity in the United States [1]. The hallmarks of AD are β-amyloid (Aβ) and tau. However, studies have indicated that metabolic dysfunction may play a more pivotal role in the progression of AD [2]. Glucose hypometabolism and mitochondrial dysfunction are well-known features of AD [2].

Research Article Open Access

Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase

Lucille M. Yanckello , Brian Fanelli , Scott McCulloch , Xin Xing , McKenna Sun , Tyler C. Hammond , Rita Colwell , Zezong Gu , Aaron C. Ericsson , Ya-Hsuan Chang , Adam D. Bachstetter , Ai-Ling Lin

Approximately 1.6-3.8 million people sustain a mild traumatic brain injury (mTBI) in the US annually. This amounts to the hospitalization of 100-300 per 100,000 young adults. The Centers for Disease Control and Prevention reports that around 5.3 million people live with a permanent disability after mTBI, and there are currently no known restorative therapies.

Commentary Open Access

Glucose Metabolism is a Better Marker for Predicting Clinical Alzheimer’s Disease than Amyloid or Tau

Tyler C. Hammond , Ai-Ling Lin

Alzheimer’s disease (AD) research has long been dominated with communications regarding the amyloid hypothesis and targeting amyloid clearance through pharmacological therapies from the brain [1]. 

Review Article Open Access

The Role of Myeloid Populations during Perinatal Liver Injury and Repair

Anas Alkhani , Sarah Mohamedaly , Amar Nijagal

The maturation of the immune system is a complex process that undergoes major transitions during fetal and neonatal development [1]. Throughout this developmental window, the response to liver injury is dependent on the nature and timing of the insult [2].

Commentary Open Access

Exploring and Targeting the Tumor Immune Microenvironment of Neuroblastoma

Katherine E. Masih , Jun S. Wei , David Milewski , Javed Khan

Neuroblastoma is derived from the developing sympathetic nervous system and is the most common extracranial solid tumor of childhood.

Commentary Open Access

The Interplay between Transcription Factor SALL4 and Histone Modifiers in Hematopoietic Stem and Progenitor Cells

Hiro Tatetsu , Daniel G. Tenen , Li Chai

Currently, there is a growing need for culturing hematopoietic stem/progenitor cells (HSPCs) ex vivo for various clinical applications such as HSPC transplantation and gene therapy. For many patients with hematologic, genetic, and immune diseases, HSPC transplants can be a life-saving treatment. There are over 20,000 patients in the US receiving HSPC transplantation yearly [1].

Review Article Open Access

A Review of the Possibility of Nafamostat Mesylate in COVID-19 Treatment

Ji-Young Rhee

Coronavirus disease 2019 (COVID-19), which started in Wuhan in December 2019, is a pandemic caused by the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (genus Betacoronavirus, family Coronaviridae).

Commentary Open Access

Hypomagnesemia and Outcomes in Hematologic Malignancies

Jennifer Gile , Joy Heimgartner , Gordon Ruan , M. Molly McMahon , Thomas Witzig

Magnesium is an essential mineral and cofactor for hundreds of enzymes and reactions. Magnesium is essential for the regulation of cell growth, division, and differentiation as well as protein synthesis, cell signaling and structural functions.

Review Article Open Access

Updates of Recent Vinpocetine Research in Treating Cardiovascular Diseases

Chongyang Zhang , Chen Yan

Vinpocetine was originally discovered and marketed under the trade name Cavinton around 1978. Vinpocetine is a synthetic derivative of the vincamine molecule which is an alkaloid extracted from the periwinkle plant, Vinca minor [1]. It has been clinically used in many Asian and Europe countries for preventing and treating neurological

Short Communication Open Access

M₁ and M₂ Macrophages Polarization via mTORC₁ Influences Innate Immunity and Outcome of Ehrlichia Infection

Ibrahim Ahmed, Nahed Ismail

Macrophages are innate immune cells that play a key role in regulation of innate and adaptive immune responses against infections with several pathogens as they respond to pathogens and tissue injury, serve as antigen presenting cells priming the adaptive immune response, drive inflammation and host defense as well as repairing