Volume 1, Issue 2, p37-51
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
In order to implement the knowledge of cancer to monitor its evolution and setting, in the last decade, new minimally invasive and repeatable samples collection have been developed such as liquid biopsy.Arch Obstet Gynecol, 2020, Volume 1, Issue 2, p37-42 | DOI: 10.33696/Gynaecology.1.006
There are many exciting developments in the field of midlife women’s health which explain how menopause symptoms, particularly hot flashes, may be an important vital sign and predictor of future health statusArch Obstet Gynecol, 2020, Volume 1, Issue 2, p37-42 | DOI: https://doi.org/10.33696/Gynaecology.1.007
A national perinatal survey in France in 2016 showed that 12.2% of women have instrumentally assisted vaginal births with vacuum extraction used in 49.8% of cases, making it the most frequently used form of obstetrical assistance.Arch Obstet Gynecol, 2020, Volume 1, Issue 2, p45-51 | DOI: 10.33696/Gynaecology.1.008
In order to implement the knowledge of cancer to monitor its evolution and setting, in the last decade, new minimally invasive and repeatable samples collection have been developed such as liquid biopsy.
Cancer is a worldwide public health issue that affects millions of people every year. In 2018 there were 17 million newly documented cases of cancer globally (8.8 million in men and 8.2 million in women), leading to 9.6 million deaths. Cancer is a vastly heterogeneous disease, with over 100 different types of cancer currently identified in humans; the most common types of cancer are lung, female breast, bowel and prostate, these four types account for more than 40% of all new cancer case
Breast Cancer is the most regularly diagnosed type of cancer in women in the world, making up on its own 25% of all cases, or nearly 2 million new cases in 2018, and 15% of all cancer related deaths, or around 626,700 deaths for that same year.
Platelets are small anuclear cells shed from the megakaryocyte, at a rate of ~1011/day , maintaining a blood concentration of 100-450 x 109/L in healthy adults. As the second most abundant circulating cells, they are becoming increasingly recognized for their versatility and cross-talks in cancer, development, immunology among others.
How medications whose major biologic effect is to reduce bile acid synthesis favorably affect the course of a variety of cholestatic and metabolic liver diseases is not immediately apparent. Also, the most frequently used plasma biomarkers for evaluating benefit, alkaline phosphatase and conjugated bilirubin , provide different information. The former may be misleading with respect to the course of the disease and therefore it is important to focus on the pathophysiologic basis for its use.
Biomarkers of Pembrolizumab Efficacy in First-Line Advanced PD-L1 ≥ 50% Non-Small Cell Lung Cancer Treatment
Lung cancer is the leading cause of cancer death worldwide. In 2020, a total of 19 million cancer patients were diagnosed, of which 11.4% were lung cancer, causing 18% of all cancer deaths. In 2020 in Spain, 29,638 cases were estimated.
Murine Models of Alcohol Consumption: Imperfect but Still Potential Source of Novel Biomarkers and Therapeutic Drug Discovery for Alcoholic Liver Disease
Improving our knowledge regarding the cellular and molecular mechanisms underlying murine models of alcoholic liver injury should enhance the management and therapies of alcoholic liver disease (ALD) seen in humans . Although none of the animal models available reproduce all main aspects of human ALD, they still provide very
The proteasome system in the cell degrades the majority of intracellular proteins. The broad nature of its substrates makes proteasome activity crucial for many cellular functions, such as protein quality control, transcription, apoptosis, immune responses, cell signaling and differentiation. The proteasome system is thus an effective therapeutic target for malignant and non-malignant diseases. In this mini-review, we would like to highlight that proteasome function has also the potential to serve as a biomarker for disease severity and response to treatment. This notion is based on the observation that the six catalytic sites of the proteasome are distinctly altered in peripheral immune cells of patients with chronic inflammatory and autoimmune diseases
Differential Expression of Long Non-coding Ribonucleic Acid (RNA) Genes in Endometriosis-associated Ovarian Cancer (EAOC): A Pilot Meta-analysis for Pathological Insights and Potential Diagnostic Biomarker Identification
Ovarian cancer affects 15 women per 100,000 in Europe  but it is not one disease. Epithelial malignancy the most common type of ovarian malignancy and defines the groups termed carcinoma [2,3]. Other malignant subtypes include sarcomas, germ cell tumors and sex-cord stromal tumors . Ovarian carcinomas are subdivided based on histological features, the most common being high-grade serous carcinoma which makes up around 70% of ovarian carcinomas [2,4]. Up to 10% of ovarian carcinomas are endometrioid subtype, having phenotypic and molecular resemblances to endometroid adenocarcinomas that arise in the endometrial cavity [3,5] Clear cell carcinoma (OCCC) and endometrioid carcinoma of the ovary (EnOC) occur on a background of ovarian endometriosis in as many as 70% of cases [6,7]. OCCC is equally as common as endometroid type, perhaps reflecting this shared origin and collectively are often referred to as Endometriosis-Associated Ovarian Carcinomas (EAOCs). Mucinous carcinoma is less common than endometriosisrelated carcinomas at around 3% of ovarian carcinomas .
Detection of Undiagnosed Elevated Cardiovascular Risk Biomarkers among HIV-Positive Patients on Antiretroviral Therapy (ART) in Kigali-City, Rwanda
Similar to other African countries, life expectancy of people living with HIV infection has improved due to access to antiretroviral therapy (ART) in Rwanda. However, both HIV infection and use of ART are associated with cardiovascular disease (CVD) risks, due to adverse changes in some biomarkers, causing dyslipidemia and other metabolic imbalances. Biomarkers for CVD risk in HIV-infected individuals taking ART, has not been well characterized in Rwanda.
The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder
Neuromyelitis Optica (NMO) is a serious condition associated with inflammation. Early diagnosis and detection are critical for early intervention. In this systematic review, we investigate the role of the neutrophil to lymphocyte ratio (NLR) as an important biomarker for NMO.
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