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Journal of AIDS and HIV Treatment
ISSN: 2688-7436
Volume 6, Issue 1, p1-53
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Beyond the Numbers: Weight Gain Risk Factors, Implications, and Interventions among Individuals with HIV
Advancements in antiretroviral therapy (ART) have significantly improved life expectancy, leading to an increased prevalence of older adults with HIV. This population may face challenges related to age-related comorbidities in addition to HIV and possibly antiretroviral therapy-related comorbidities. Among those, weight gain has emerged as an increasingly recognized problem raising clinical concern.
J AIDS HIV Treat, 2024, Volume 6, Issue 1, p1-10 | DOI: 10.33696/AIDS.6.047Potential Advantages of a Well-balanced Nutrition Regimen for People Living with Human Immunodeficiency Virus Type -1
This review underscores the important role of nutrition in enhancing the management of Human Immunodeficiency Virus type 1 (HIV-1). Highlighting the efficacy of dietary interventions, including, the importance of omega-3 fatty acids, vitamins D and B-12, and the Mediterranean diet, we delineate how these beneficial nutritional strategies can improve the effectiveness of combined antiretroviral therapy (cART), mitigate its side effects, and ameliorate metabolic disorders in people living with HIV-1 (PLWH).
J AIDS HIV Treat, 2024, Volume 6, Issue 1, p11-27 | DOI: 10.33696/AIDS.6.048HIV/AIDS Care and Support Services Satisfaction for Orphan and Vulnerable Children in Northwest Ethiopia: Mixed Method Study
Background: The provision of comprehensive care and support services to orphans and disadvantaged children that are individualized and tailored through the use of child- and family-centered information is critical but little if any information is available on satisfaction with HIV/AIDS care among orphans and vulnerable children in Gondar. Therefore, this study aimed to assess the satisfaction of HIV/AIDS care and support service delivered to caregivers of Orphans and Vulnerable Children, Gondar City, 2023.
J AIDS HIV Treat, 2024, Volume 6, Issue 1, p28-36 | DOI: 10.33696/AIDS.6.049Magnitude of HIV Index Case Testing among HIV Positive Clients Attending ART Clinic in University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2023
Background: Index case testing is the provision of HIV testing services to family members or sexual partners of individuals already diagnosed with HIV. Its promotion stems from its potential to detect new cases, improve testing coverage, enhance ART retention, and provide convenience to affected families. Although evidence on index case testing in Ethiopia, particularly in the study area, is lacking, even, it is regarded as a crucial strategy for reducing HIV transmission among those unaware of their HIV status.
J AIDS HIV Treat, 2024, Volume 6, Issue 1, p37-43 | DOI: 10.33696/AIDS.6.050Bending the Curve Through Innovations to Overcome Persistent Obstacles in HIV Prevention and Treatment
Background: HIV/AIDS remains a major global public health challenge despite significant progress in treatment. New infections and HIV-related deaths persist, fueled by disparities in prevention and care access. Purpose: This review synthesizes recent advances across key domains - from vaccine development to novel treatments to omics approaches – that collectively hold promise for ending the HIV/AIDS pandemic.
J AIDS HIV Treat, 2024, Volume 6, Issue 1, p44-53 | DOI: 10.33696/AIDS.6.051A Bioinformatics Protocol for Rational Design of Peptide Vaccines and the COVID-19 Rampage
The currently ongoing coronavirus pandemic, the SARSCOV- 2, interchangeably referred to as the COVID-19 infection, has in a short span of time altered the ways and means of almost all of mankind. So strong has been its effect that all human activity ceased in one way or another for a considerable time, led to significant loss of life and economic drain of.
Mega-Dose Dietary Riboflavin in Treatment in Keratoconus, Post-Refractive Cornea Ectasia and Migraine. Has Its Time Arrived?
Recently, several studies and investigators have shown the beneficial effects of high dose dietary riboflavin (vitamin B2) in the treatment of keratoconus, post-refractive (LASIK, PRK & Radial Keratotomy) ectasia (with sunlight exposure) and patients treated with our own protocol (NIH Clinical Study – www.clinicaltrials.gov - # NCT 03095235) discovered significant relief for intractable migraine headaches and/or ophthalmic migraine (classic migraine visual symptoms without headache).
How Well Do Hemodialysis Patients Respond to the BNT162b2 mRNA COVID-19 Vaccine?
In January 2020, the World Health Organization (WHO) classified COVID-19 to be a Public Health Emergency of International Concern and declared it a pandemic on March 11, 2020 [1]. Over one hundred and eighty-five million people have been infected by SARS-CoV-2 and roughly four million have died worldwide so far
Role of the Gut Microbiome in the Modulation of Cancer Immunotherapy Response
The gut microbiome or gut flora is a vast community of microorganisms such as bacteria, viruses, protozoa, and fungi that inhabit the digestive tract of the human and other animals [1,2]. In the human body, bacterial species colonize into the oral cavity, skin, vagina, and placenta, however, the largest population of microorganisms resides in the intestine.
Diet and Exercise: A Novel Cure for Asthma? - A Short Communications on a Non-Pharmacological Strategy
Behavioral interventions with regular physical activity, weight loss and diet have repeatedly demonstrated preventive effects in a wide range of diseases. Furthermore, an unhealthy lifestyle is a known predictor for increased use of medication and also the leading risk factor for global mortality.
Intestinal Barrier Function – a Novel Target to modulate Diet-induced Metabolic Diseases
High fat high cholesterol containing Western-type diet (WD)-induced obesity remains one of the major causes for the development of metabolic syndrome and associated metabolic diseases such as Type 2 Diabetes (T2DM) and atherosclerosis (that leads to cardiovascular diseases including heart disease and stroke). In addition to changes in lipid metabolism and excessive lipid accumulation, recent studies have also described direct effects of WD on gut microbiome and attributed dysbiosis of gut flora to the observed metabolic effects.
Tenofovir at the Crossroad of the Therapy and Prophylaxis of HIV and HBV Infections
Tenofovir, alias (R)-PMPA, was first divulged as an anti- HIV agent in 1993 [1]. That it would in 2012, become the first antiretroviral agent, approved by the US FDA (Food and Drug Administration) to prevent HIV infection, could have been predicted from the findings of Tsai et al.
Folic acid-chitosan Nanomaterials for delivery of dietary polyphenols
Despite the health benefits associated with polyphenols, the bioavailability of many polyphenols limits their effects. Problems with poor solubility fast-metabolism and food preparation techniques limit the bioavailability and bioactivity of these dietary micronutrients. Encapsulation of polyphenols has shown to protect and increase bioavailability of these dietary compounds and to enhance their anticancer activity.
Archives of Gastroenterology Research: A Message from Prof. Dr. Rolf Teschke (Editor-in-Chief)
As the new editor-in-chief of Archives of Gastroenterology Research (AGR) I cordially welcome all current readers of AGR and future contributors to AGR. Together with my editorial team of AGR we encourage scientists and clinicians involved in the care of patients with gastrointestinal diseases to submit their interesting reports to AGR with the aim to be published following fair evaluation by external peer reviewers
Relative COVID-19 Vaccine Booster Effectiveness and ClinicalEpidemiological Characteristics Before and After 29 Days of Shot
Background: When the highest vaccine COVID-19 booster effectiveness (VBE) is obtained is not clearly known. Objective: To compare the cases of COVID-19 in booster vaccinated people with a time of <29 days vs. ≥ 29 days from booster to infection diagnosis and assess their relative VBE. Methodology: An observational, longitudinal and prospective case series study of adult patients with COVID-19 breakthrough infections in booster vaccinated people, in general medicine and for the period December 2021 to February 2022, during the omicron variant contagion wave.
Primary Lymph Node Kaposi's Sarcoma in Two HIV Positive Patients Presenting with Generalized Lymphadenopathy and Pancytopenia in a Third Level Hospital in Guatemala
We present two unique cases in which two HIV positive patients with generalized lymphadenopathy and pancytopenia without any skin lesions were diagnosed with primary lymph node Kaposi´s Sarcoma after excisional biopsy of an inguinal lymph node.
CCR5 Inhibitors and HIV-1 Infection
Cellular components are attractive targets for antiviral therapy because they do not mutate as readily as do viral proteins do [1-3]. The identification of CCR5 as an HIV-1 coreceptor [4-7], facilitated by the discovery of the antiviral activities of CCR5 ligand ?-chemokines [8], resulted in the development of new viral entry inhibitors to block CCR5 binding, including both- small molecules and CCR5 antibodies
Recent Progress in Preclinical HIV-1 Vaccine Research
Since isolation in humans in 1983 [1,2], HIV-1 has developed into a global pandemic. But an effective HIV-1 vaccine has not been succeeded despite multiple human vaccine trials performed [3,4]. Challenges to an effective vaccine arise from intrinsic virological and immunological features of HIV-1 [3-8].
Anti-HIV-1 Activity of Crocodylus mindorensis (Philippine Crocodile) Serum in Cell-free and Cell-associated Virus Interactions to Human Peripheral Blood Mononuclear Cells
Highly-Active Antiretroviral Therapy (HAART) is the recommended treatment and management strategy for HIV infection. Although the existing antiretroviral drugs are indispensably significant in improving the quality and extending the lives of HIV/ AIDS individuals, the drugs still have many limitations including development of resistance, production of toxicity, and their limited availability.
Assessment of Attitudes toward HIV and AIDS among Undergraduate Students at a Historically Black University
HIV is no longer only a public health challenge, but also a global threat with a devastating negative impact that has claimed over 35 million lives globally. In 2017, about 36.9 million people live with HIV, and 1.8 million people becoming newly infected with the disease globally [1].
Health Workers’ Perspectives on the Outcomes, Enablers, and Barriers to the Implementation of HIV “Test and Treat” Guidelines in Abuja, Nigeria
HIV/AIDS continues to be a major public health disease accounting for 35 million deaths across the world. In 2016 alone, there were 1.8 million new HIV infections and 1 million deaths worldwide.
HIV-1 Treatment Failure among Population Taking Antiretroviral Therapy in Ethiopia
For more than 35 years, the world has grappled with an AIDS epidemic that has claimed an estimated 35.0 million [28.9 million-41.5 million] lives and at its peak threatened global stability and security.
Rate and Predictors of Treatment Failure among Pediatric Population Taking Highly Active Antiretroviral Therapy in Ethiopia
The global scaling up of treatment and care for people living with Human Immunodeficiency Virus (PLHIV) has led to a 43% decline in new HIV pediatric infections since 2003, with 330,000 newly infected children in 2011.
Development of an Ultrasensitive HIV-1 DNA Detection Assay Based on an Automated πCode End-Point PCR System
Currently, around 60-75% of the HIV positive patients in developed countries on anti-retroviral therapy (ART) have undetectable plasma viral load using current diagnostic PCR assays.
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations
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