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2022

Volume 4, Issue 1, p1-40

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Incidence of Nephrotoxicity among People Living with Human Immunodeficiency Virus on Tenofovir Treatment in a Tertiary Hospital in the Philippines

Tenofovir disoproxil fumarate (TDF) is one of the main antiretroviral drugs of people living with human immunodeficiency virus (PLWHIV). Despite its efficacy and tolerability, there is conflicting evidence regarding TDF-associated nephrotoxicity, which is proposed to cause injury by accumulation of tenofovir (TFV) within proximal tubular cells leading to mitochondrial injury and tissue hypoxia. 

J AIDS HIV Treat, 2022, Volume 4, Issue 1, p1-5 | DOI: 10.33696/AIDS.4.025

Pregnancy Outcomes in Pregnant Women with HIV on Tenofovir Disoproxil Fumarate (TDF) Compared to Tenofovir Alafenamide (TAF)

HIV infection in pregnancy continues to be of significant clinical and public health importance [1,2]. The current statistics published by the World Health Organization (WHO) demonstrate that 38 million people are living with HIV in 2019, and 1.1 million (85%) pregnant women living with HIV received antiretroviral therapy (ARVs) during pregnancy and postpartum.

J AIDS HIV Treat, 2022, Volume 4, Issue 1, p6-13 | DOI: 10.33696/AIDS.4.026

Known and New Routes to Neutralize HIV-1 with Camelid Single Chain Antibody Fragments

In spite of all efforts to reduce transmission of HIV-1, 1.7 million persons were infected in 2019 worldwide. Whereas in the developed countries the COVID-19 pandemic is reasonably controlled within 2 years because of the fast and successful development of vaccines, nearly 40 years after the first reported cases of AIDS due to HIV-1 and in spite of tremendous efforts to develop vaccines against HIV-1, there are still no vaccines against the virus.

J AIDS HIV Treat, 2022, Volume 4, Issue 1, p14-21 | DOI: 10.33696/AIDS.4.027

Tenofovir Alafenamide, Emtricitabine, and Bictegravir in Switch Strategy for HIV-1 Adult Patients Due to Previous Renal Impairment Induced by Tenofovir Disoproxil Fumarate

 Non-AIDS comorbidities, metabolic, renal and bone toxicities associated to combined antiretroviral therapy (cART), namely NRTIs, led to dual therapy (NUC sparing regimens). Tenofovir Alafenamide Fumarate (TAF) demonstrated improved renal and bone safety profile over TDF even with mild to moderate renal impairment.

J AIDS HIV Treat, 2022, Volume 4, Issue 1, p22-29 | DOI: 10.33696/AIDS.4.028

Patient Satisfaction and Perceptions Regarding Anti-Retroviral Therapy (ART) Services in Rural Southwestern Uganda

Patient satisfaction and perception of the healthcare services received contribute to compliance with treatment guidelines, retention in care, and adherence to recommendations. This is especially so in the treatment of chronic medical conditions such as HIV/AIDS. The success of antiretroviral therapy (ART) plays a fundamental role in determining the quality of life of people living with HIV/AIDS (PLWHAs).

J AIDS HIV Treat, 2022, Volume 4, Issue 1, p30-40 | DOI: 10.33696/AIDS.4.029

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