Archives of Gastroenterology Research

Commentary Open Access

Oral Lactulose – A Safe and Effective Strategy for the Management of Constipation in Individuals with Impaired Glucose Tolerance and Diabetes

Valentin Faerber, Katharina Stefanie Kuhn, Eva Svehlikova, Angelika Kuchinka-Koch, Thomas R Pieber

Gastrointestinal (GI) disorders are common, also in persons with diabetes mellitus (DM), and can substantially impact their quality of life. In a representative sample of adults living in the United States, 25.8% of individuals with DM also reported disordered bowel habits and 14.6% experienced chronic constipation [3]. Others have reported an even higher prevalence of constipation of around 30% among patients with DM. While, in some patients, symptoms can be relieved with lifestyle and dietary modifications, many individuals with DM rely on the regular use of laxatives for the management

Case Report Open Access

Gastric GIST with 13 kg in Asymptomatic Patient: A Rare Case of Giant GIST and Literature Review

Flávio Silano, Ricardo Bandeira de Melo Amaral, Vanessa Costa Neves, Rodolfo Carvalho Santana, Paulo Cezar Galvão do Amaral

Although gastrointestinal stromal tumors, GISTs, are the most common neoplasms arising from the gastrointestinal mesenchyme, they represent less than 1% of all digestive tumors. Its incidence has increased in recent years, probably due to improved diagnostic methods. It is currently known that GIST is the most common sarcoma. It originates from interstitial cells of Cajal and depends on the transcription factor ETV-1. These are neoplasms associated with molecular alterations and some mutations.

Short Communication Open Access

New Trends in Interrelation of Infectious Colorectal Cancer with Intestinal Microbiota

Vishnu P. Tripathi, Daniel Goo, Bokyo N Maidya, M K Aneebuddin

The intestinal microbiota creates a bodily barrier for invading pathogen by using aggressive exclusion. Pathogens and immune cells can interact directly and dynamically with symbiotic bacteria, determining the pathophysiology and outcome of an infection. They can defend the host through a variety of processes, including attachment site occupancy, nutrition intake, metabolite competition, and the synthesis of antimicrobial compounds including bacteriocins that influence pathogen survival (a process referred to as colonization resistance).

Short Communication Open Access

Elucidating the Role of Chemokines in Infectious Diseases and Gastric Cancer

Vishnu P. Tripathi, Haamza Ahmed, Naidia Renulos, M K Aneebuddin

Although the prevalence of gastric cancer is decreasing in many developed nations, it is the fourth most prevalent cancer and the second leading cause of cancer-related deaths globally. Around 8 percent of recently diagnosed malignant tumors are stomach cancer, more than 7,00,000 individuals die from gastric cancer yearly. Despite extensive research into new diagnostic and therapeutic methods, the prognosis for individuals with advanced stomach cancer remains dismal, and survival rates have hardly improved. In recent years, many latest innovations have improved our understanding of the molecular mechanisms and modifications that contribute to gastric cancer’s beginning and progression, including several genetic and molecular modifications and mutations.

Short Communication Open Access

Intraductal Tubular Adenoma: A Case Report and Diagnostic Algorithm for Intraductal Pancreatic Lesions

Shivali Desai, Christine MG Schammel, David Durantel, A Michael Devane, Steven D Trocha

Intraductal lesions of the pancreas are an increasingly recognized, radiologically detectable group of entities that require a systematic diagnostic approach to best define management given their variable prognoses. A case of isolated intraductal tubular adenoma (ITA) is reported with a comprehensive literature review; comparison of ITAs with intraductal papillary mucinous neoplasms (IPMNs) and intraductal tubular carcinomas (ITCs) is made with assessment of their distinctive imaging and histological findings and discussion of the evolution of these lesions’ classifications with regards to the established literature.