Volume 4, Issue 1, p1-24
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
A Customized Artificial Pancreas System with Neural Network based Model Predictive Control for Type 1 Diabetic Rats
Advances in sensor and computing technology have enabled researchers to develop artificial pancreas systems (APS) that can mimic the glucose regulation function of a healthy pancreas to treat type 1 diabetes mellitus (T1DM). APS use a continuous glucose monitor (CGM) sensor to read the latest blood glucose level (BGL).J Diabetes Clin Res, 2022, Volume 4, Issue 1, p1-9 | DOI: 10.33696/diabetes.4.049
A Machine Learning Study of 534,023 Medicare Beneficiaries with COVID-19: Implications for Personalized Risk Prediction for People Over 65
The global outbreak of COVID-19 has resulted in over 378 million infections and worldwide deaths have surpassed 5.6 million. In the United States, there have been over 75 million confirmed cases and over 886,000 deaths as of February 1, 2022.J Diabetes Clin Res, 2022, Volume 4, Issue 1, p10-16 | DOI: 10.33696/diabetes.4.050
Germany was the first country worldwide to implement German Digital Healthcare Act in 2019 to allow prescription and reimbursement of digital health applications (Digitale Gesundheitsanwendungen, DiGA). The German Federal Government has prioritized increased usage of mobile-Health (m-Health: use of mobile devices and digital technology in health care), recommending that physicians, other healthcare professionals, and patients work together to utilize the potential benefits of such technology.J Diabetes Clin Res, 2022, Volume 4, Issue 1, p17-19 | DOI: 10.33696/diabetes.4.051
Diabetes is a chronic disorder that affects more than 500 million individuals worldwide. It is a life-long disease with complications that attack nearly all other systems within the body. Although there is a slight increase in the prevalence of diabetes in males, ocular surface complications are equally present in males and females.J Diabetes Clin Res, 2022, Volume 4, Issue 1, p20-24 | DOI: 10.33696/diabetes.4.052
While the global COVID-19 pandemic has challenged the entire humanity and health systems, it also triggered researchers to urgently perform clinical trials to assess the safety and efficacy of many agents and modalities to combat COVID-19. As of April 22, over 650 clinical studies have been registered both in USA and internationally. Results from these studies are also coming at a brisk pace in this unprecedented emergency.
Wound healing is a dynamic process whereby cellular structures and the tissue layers are reconstructed. Adult wound healing can be categorized into three stages: inflammatory phase, proliferative phase, and remodelling phase. Blood cells like macrophages, neutrophils, extracellular matrix and mediators, various proteins, and various genes play an important role in these phases.
Diagnosis is a process that identifies, explains, or establishes the individual’s disease from its symptoms and signs. Early and precise diagnosis is crucial since it influences the efficacy of treatment and avoids longterm complications for the infected person. Further, in the case of infectious diseases, undiagnosed patients can transmit the disease to a healthy population unknowingly. Besides, most of the diseases evolve with the time that significantly affects the clinical outcomes.
How Traditional Healers Diagnose and Treat Diabetes Mellitus in the Pretoria Mamelodi Area and How Do These Purported Medications Comply with Complementary and Alternative Medicine Regulations
CAM is widely used by patients to treat and prevent certain diseases, providing emotional and physical support . The National Centre for Complementary and Alternative Medicine (NCCAM) defines CAM as a “group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine” .
Insulin resistance has been studied extensively at systemic, organ, tissue and cellular and molecular levels. Overnutrition plays an essential role in the development of chronic metabolic diseases such as obesity and type 2 diabetes. For subjects without genetic defects, the development of insulin resistance and type 2 diabetes is a graduate process. How the transition from an insulinsensitive state to an insulin-resistant state occurs, and what the roles of nutrients are in the process have not been fully understood. Here, we try to summarize the current understanding of insulin-regulate gene expression in the liver, and describe a phenomenon of hepatic insulin resistance at gene expression (HIRAGE), which may be linked to overnutrition.
Obesity has reached a global epidemic and it predisposes to the development of insulin resistance, type 2 diabetes and related metabolic diseases. Current interventions against obesity and/or type 2 diabetes such as calorie restriction, exercise, genetic manipulations or established pharmacological treatments have not been successful for many patients with obesity and/or type 2 diabetes.
Artificial Intelligence and Machine Learning in Cancer Care: Current Applications and Future Perspectives
Cancer is the second most common cause of death worldwide, accounting for an estimated 9.6 million deaths in the year 2018, a number that is expected to grow to more than 13 million by 2030. In the past decade, we have witnessed unprecedented scientific advancement in the understanding of cancer etiology, prevention, diagnosis and development of new therapeutic strategies.
Diabetes mellitus (DM) is an age-related metabolic disorder affecting 347 million people in modern society. Expanding its prevalence beyond developed countries, DM has emerged as a global public health issue associated with a high morbidity and mortality.
Diabetes mellitus is a common metabolic disorder that present with abnormal glucose metabolism. This metabolic disease is prevalent in many countries, worldwide. It is no doubt there might be a chance that diabetes mellitus might co-occur with other medical problems.
Since the declaration of COVID-19 as a pandemic in March 2020 , there have been more than 100 million reported cases of COVID-19 worldwide and more than 2.1 million deaths .
COVID-19 and the Health of Illicit Substance Users: Preliminary Analysis from Illicit Drug Transaction Data
While much attention has been given to how COVID-19 patients are treated (or fail to be treated), the impact of the pandemic on illicit drug users remains largely undiscussed
The Clinical Utility of Outpatient Continuous Glucose Monitoring in Establishing Insulinoma Diagnosis in a Patient with Impaired Nocturnal Hypoglycemia Awareness
Insulinomas are insulin secreting tumors arising from spontaneous mutations of the ductal, acinar, or islet cells of the pancreas. They are rare, having an incidence of only four cases per million people per year. Patients typically present with fasting hypoglycemia, experiencing neurologic symptoms like confusion, changes in vision, or abnormal behavior and autonomic symptoms like palpitations, diaphoresis, or tremulousness.
COVID-19 Rapid Diagnostic Test Results and their Associations with Certain Factors Among the Residents of Balochistan
This paper analyses any possible association of various factors like gender, last COVID-19 PCR test results, BCG Vaccination, Seasonal Flu vaccination, occupation and confirmed case contact history with COVID-19 RDT results of the participants.
Diabetes is approaching epidemic proportions worldwide. In the United States, there are more than 30 million individuals having a confirmed diagnosis of diabetes [1,2]. Worldwide, the number of people with diabetes exceeds 400 million , and is expected to reach 550 million by 2030. Diabetes is associated with complications that affect nearly all systems, including vision.
The question of whether or not correction of vitamin D deficiency might reduce the risks of later type 2 diabetes mellitus (T2DM) has been under debate for many decades. The necessity of vitamin D for normal insulin secretion was first identified experimentally in the 1980s.
Investigation of Regimen Adjustment for T2DM Patients Inadequately Controlled on Basal Insulin – Interpretation of the 4200 Study
Epidemiological survey indicated that majority of Chinese T2DM patients were with postprandial hyperglycemia, which may be related to more significant decline of ? cell function and more carbohydrates in dietary structure.
With increasing rates of obesity, rates of type 2 diabetes and diabetic complications are expected to rise exponentially over the next few decades (American Diabetic Association). A key feature of type 2 diabetes is a resistance to insulin. Insulin signaling is key to a number of physiological processes, including glucose metabolism, cell growth, general gene expression, and apoptosis.
The COVID-19 pandemic started at the end of 2019 and remains carrying a health threat and significant economic consequences. Over the last two years, COVID-19 has been the main Public Health issue, and has impacted regular healthcare systems, with significant build-up of waiting lists and delay in optimum management of other serious medical conditions including heart diseases and cancer.
Identification of Risk Markers for Poorly Controlled Type 2 Diabetes Mellitus: A Retrospective Cross-Sectional Study with Focus on Quality Assurance Based on Real World Data
Type 2 diabetes mellitus (T2DM) is a metabolic disease defined by hyperglycemia. If not treated, chronic and even short periods (i.e. weeks) of undesirable hyperglycemia increases the risk for developing diabetic microvascular complications such as retinopathy, neuropathy, nephropathy, foot ulcers and amputations, and macrovascular complications such as cardiovascular disease including stroke
Stroke is a major cause of death and disability in the world. There were approximately 25.7 million stroke survivors and 6.5 million deaths from stroke . Stroke can result in arm disability and reduce daily life activity via weak arm muscle activity . Studies have been performed to discover therapeutic and assistive approaches to compensate for disabilities and restore functions.
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