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Journal of Experimental Pathology
ISSN: 2694-5061
Volume 5, Issue 1, p1-13
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Therapeutic Pathology- The Pathology of Tomorrow
As pure science, pathology has always been the backbone of every aspect of diagnosis in medical practice. Although the main focus has been on the classification of the disease entities and their association with the prognosis of the condition, the focus has been shifting towards more practical applications- the ‘therapeutic uses’.
J Exp Pathol, 2024, Volume 5, Issue 1, p1-5 | DOI: 10.33696/pathology.5.045Retesting of Neonatal Hearing Screening Before and During the COVID-19 Pandemic: A Longitudinal Study
Introduction: Universal Newborn Hearing Screening (UNHS) plays an essential role in the early identification of hearing loss in neonates. Risk factors for hearing impairment may include family history, prematurity, and exposure to ototoxic substances. Coronavirus Disease 2019 (COVID-19) might be a significant contributing factor affecting the structures of the inner ear.
J Exp Pathol, 2024, Volume 5, Issue 1, p6-13 | DOI: 10.33696/pathology.5.046Early Onset Fetal Growth Restriction: Does Path to Diagnosis Impact Outcomes and Pathology?
The etiology of fetal growth restriction is rooted in inadequate maternal-placental vascular malperfusion (MVM) of the placenta. Risk factors for MVM are broad and include maternal, fetal, and placental antecedent determinants.
Do Support Vector Machines Play a Role in Stratifying Patient Population Based on Cancer Biomarkers
Cancer is a worldwide public health issue that affects millions of people every year. In 2018 there were 17 million newly documented cases of cancer globally (8.8 million in men and 8.2 million in women), leading to 9.6 million deaths. Cancer is a vastly heterogeneous disease, with over 100 different types of cancer currently identified in humans; the most common types of cancer are lung, female breast, bowel and prostate, these four types account for more than 40% of all new cancer case
Salivary Protein Antigens for Breast Cancer Biomarkers
Breast Cancer is the most regularly diagnosed type of cancer in women in the world, making up on its own 25% of all cases, or nearly 2 million new cases in 2018, and 15% of all cancer related deaths, or around 626,700 deaths for that same year.
Strong Association Between Placental Pathology and Second-trimester Miscarriage
The survival probability of early human conceptions is very low. At least 73% of natural single conceptions have no real chance of surviving six weeks of gestation [1]. After six weeks, survival rates improve rapidly as 90% of the remainder will survive to term.
Importance of Autopsy from a Gastrointestinal Pathology Perspective: A Ten-year Review of 891 Autopsies
There has been a decline in autopsy rates by 58% from 1972-2007. The major reason for this decline is the ability to diagnose diseases and disorders that result in mortality with greater accuracy. Additionally, the Joint Commission on Accreditation of Healthcare Organizations dropped the standard practice of requiring a 20-25% autopsy rate for in-hospital deaths. The perception or attitude towards autopsies from both family members and clinicians is changing leading to a further decrease in the autopsy numbers.
Obeticholic Acid, FXR Agonists, Liver Disease and Plasma Biomarkers
How medications whose major biologic effect is to reduce bile acid synthesis favorably affect the course of a variety of cholestatic and metabolic liver diseases is not immediately apparent. Also, the most frequently used plasma biomarkers for evaluating benefit, alkaline phosphatase and conjugated bilirubin [1], provide different information. The former may be misleading with respect to the course of the disease and therefore it is important to focus on the pathophysiologic basis for its use.
Study on Imaging Findings, Pathology and Treatment of Cerebellar Infarction
To explore the pathological mechanism and clinical treatment of cerebellar infarction through the clinical imaging changes of cerebellar infarction.
Neuromotor Impairment, Hearing Loss and Blindness in a Preclinical Mouse Model of Charcot Marie-Tooth Disorder
In the peripheral nervous system (PNS), Schwann cells (SCs) are responsible for myelin production, which contributes to axonal protection and allows for efficient action potential transmission. Unfortunately, acquired and hereditary demyelinating diseases of the PNS are numerous and affect an increasing number of people.
Resveratrol Treatment Reduces Neuromotor Impairment and Hearing Loss in a Mouse Model of Diabetic Neuropathy and Nerve Injury
In the peripheral nervous system (PNS), Schwann cells (SCs) are responsible for myelin production, which contributes to axonal protection and allows for efficient action potential transmission. Unfortunately, acquired and hereditary demyelinating diseases of the PNS are numerous and affect an increasing number of people.
Toward Integrated Genomic Diagnosis in Routine Diagnostic Pathology by the World Health Organization Classification of Acute Myeloid Leukemia
Significant milestones and seminal discoveries during 1674-1966, by individuals who have made crucial contributions toward progress in the diagnosis of hematologic neoplasms as we understand today are depicted chronologically. It is notable that the path to progress in the understanding of disease and neoplasms initially took centuries for significant discoveries (17th-18th centuries), and subsequently, many decades (19th-20th centuries) for a breakthrough or a change from the prevailing norm.
Biomarkers of Pembrolizumab Efficacy in First-Line Advanced PD-L1 ≥ 50% Non-Small Cell Lung Cancer Treatment
Lung cancer is the leading cause of cancer death worldwide. In 2020, a total of 19 million cancer patients were diagnosed, of which 11.4% were lung cancer, causing 18% of all cancer deaths. In 2020 in Spain, 29,638 cases were estimated.
Newborns’ Hearing Health Associated with Infectious Diseases in Primary Healthcare Infectious Diseases and Neonatal Hearing Screening
According to the World Health Organization [1], hearing loss is unevenly distributed worldwide and importantly associated with each region’s per capita income. Hearing is one of the most important human senses [2], and a healthy auditory system is a prerequisite to language and auditory skill development [3]. Hence, it is a serious matter for patients when their auditory health is affected.
Murine Models of Alcohol Consumption: Imperfect but Still Potential Source of Novel Biomarkers and Therapeutic Drug Discovery for Alcoholic Liver Disease
Improving our knowledge regarding the cellular and molecular mechanisms underlying murine models of alcoholic liver injury should enhance the management and therapies of alcoholic liver disease (ALD) seen in humans [1]. Although none of the animal models available reproduce all main aspects of human ALD, they still provide very
In vivo Neuropathology: Detecting the Neurotoxicity of Candidate Drugs during Early Drug Discovery
Twenty-five percent of small molecules in drug development for CNS indications fail in clinical trials due to complications with neurotoxicity. Unfortunately, this is not discovered earlier. Indeed, it is very infrequent that a drug is flagged for neurotoxic side effects in early drug discovery (1). The consequences are two-fold: 1) loss of time and money in bringing new drugs to market and, 2) the unwitting exposure of patents in clinical trials to the neurotoxic side effects of what otherwise could be a drug candidate that is effectively treating the problem.
Detection of Undiagnosed Elevated Cardiovascular Risk Biomarkers among HIV-Positive Patients on Antiretroviral Therapy (ART) in Kigali-City, Rwanda
Similar to other African countries, life expectancy of people living with HIV infection has improved due to access to antiretroviral therapy (ART) in Rwanda. However, both HIV infection and use of ART are associated with cardiovascular disease (CVD) risks, due to adverse changes in some biomarkers, causing dyslipidemia and other metabolic imbalances. Biomarkers for CVD risk in HIV-infected individuals taking ART, has not been well characterized in Rwanda.
The Effects of COVID-19 on Pregnancy Outcomes, as well as the Impact on Fetuses and Newborns: Cross-Sectional Study
Background: Pregnant women, fetuses, and newborns are at a higher risk of exposure to infectious diseases during outbreaks compared to other populations. Objectives: The purpose of this study is to investigate the effects of COVID-19 on pregnancy outcomes, as well as the impact on fetuses and newborns in Kurdistan, Iran. The study will cover the period from February 2020 to January 2021.
Therapeutic Pathology- The Pathology of Tomorrow
As pure science, pathology has always been the backbone of every aspect of diagnosis in medical practice. Although the main focus has been on the classification of the disease entities and their association with the prognosis of the condition, the focus has been shifting towards more practical applications- the ‘therapeutic uses’.
Retesting of Neonatal Hearing Screening Before and During the COVID-19 Pandemic: A Longitudinal Study
Introduction: Universal Newborn Hearing Screening (UNHS) plays an essential role in the early identification of hearing loss in neonates. Risk factors for hearing impairment may include family history, prematurity, and exposure to ototoxic substances. Coronavirus Disease 2019 (COVID-19) might be a significant contributing factor affecting the structures of the inner ear.
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