Journal of Cancer Immunology

2023

Volume 5, Issue 1, p1-60

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Editorial Open Access

Role of Liver Navigation in Surgery Planning and the Challenges

Sarada Prasad Dakua, Sagnika Dash, Sagarika Pati, Julien Abinahed

With continuous advancement of high dimensional imaging devices and the development of new image computing and visualization techniques, the world of interventional radiology and surgical care has achieved new heights. Computer vision and image processing plays an important role in health care, such as analysis, visualization, and exploration of medical image data.

J Cancer Immunol, 2023, Volume 5, Issue 1, p1-4 | DOI: 10.33696/cancerimmunol.5.070

Commentary Open Access

Early Integration of Palliative Care for Patients Receiving Systemic Immunotherapy for Renal Cell Carcinoma

Megan Stout, Akshay Thaper, Vivien Xu, Eric A. Singer, Biren Saraiya

Palliative care (PC) aims to prioritize the quality of life and comfort of those with complex and terminal illnesses through the physical, psychological, social, and spiritual needs of the individual. Palliative care can support individuals from the day of their cancer diagnosis through end-of-life and bereavement

J Cancer Immunol, 2023, Volume 5, Issue 1, p5-12 | DOI: 10.33696/cancerimmunol.5.072

Review Article Open Access

Insights from Long Noncoding RNAs into Cancer-immunity Cycle Regulation

Ye-Lin Liang, Yuan Zhang, Xi-Rong Tan, Han Qiao, Jun Ma, Ying-Qin Li, Na Liu

Accumulating evidence from recent research offers new perspectives on the functions of long non-coding RNAs (lncRNAs) in immunooncology. In addition to modulating the aggressiveness of cancer cells, lncRNAs are essential players in regulating various immune cells and stromal cells, playing a role in reshaping the tumor microenvironment and affecting anti-tumor immunity.

J Cancer Immunol, 2023, Volume 5, Issue 1, p13-28 | DOI: 10.33696/cancerimmunol.5.073

Research Article Open Access

Negative Feedback Expansion of Tregs Caused by Endogenous IL-2 Limits the Activity of IL-2-based Therapies

Inbar Amit, Natalie Levitin, Meital Gadrich, May Ben-Mayor, Timothy Wyant, Reut Barak, Liron Danielpur, Morya Ifrach, Itzhak Meir, Olga Bluvshtein, Yehezkel Sasson, Sharon Fischman, Guy Nimrod, Michael Zhenin, Yair Fastman, James Vasselli, Aron Knickerbocker, Ronald Herbst, Yanay Ofran

Stimulating effector T-cells (Teffs) without inducing regulatory T-cells (Tregs) has been the primary goal of IL-2-based therapies for cancer. Recently, modified IL-2 designed for differential T-cell expansion for the treatment of cancer has failed in the clinic. We propose that treatments based on exogenous administrations of modified IL-2 are inherently undermined by a negative feedback loop, caused by IL-2 secreted endogenously from activated effector T-cells.

J Cancer Immunol, 2023, Volume 5, Issue 1, p29-39 | DOI: 10.33696/cancerimmunol.5.074

Review Article Open Access

Epithelial Mesenchymal Transition: The Ultimate Driver of Cancer on Difficult Paths

Devavrat Tripathi, Pramod Kumar Gupta, Savita Kulkarni

Metastasis is the perilous aspect of cancer and is responsible for 90% of deaths due to cancer. It represents an enigmatic and complex biological cascade that is poorly understood. The constant development in cancer research and the advent of new principles in metastasis have discovered some of the molecular keystones like epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) of this cascade.

J Cancer Immunol, 2023, Volume 5, Issue 1, p40-60 | DOI: 10.33696/cancerimmunol.5.075

Submit Manuscript

Recommended Articles

Prevalence of Symptom Clusters in Cancer Patients at First Presentation in Palliative Care Clinic as per Different Disease Groups

Cancer has its own disease burden and patients usually suffer from symptom clusters when they are referred for palliative treatment. Identification of symptom cluster trajectories will help clinician to take into account measures that can optimize quality of life of palliative patients. Therefore the aim of this paper is to determine the overall prevalence of symptoms and symptoms clusters in different disease groups according to etiology at the time of first visit to Palliative care clinic by using HIS Palliative First Assessment note indicating Edmonton symptom scale.

Chimeric Antigen Receptor CAR NK Cells Emerging Immunotherapy for the Treatment of Cancer

Although NK cells are recognized as effector lymphocytes of the innate immune system, they also regulate the adaptive immune response by releasing inflammatory cytokines and developing immunological memory. Unlike other lymphocytes such as T or B cells, NK cells do not express rearrangeable, antigen-specific receptors.

Emerging Role of TRPML1 Mucolipin Endolysosomal Channel in Cancer

The transient receptor potential mucolipin 1 (TRPML1) is an endolysosomal channel belonging to the TRP family. Clinically, mutations of TRPML1 have been responsible for a severe lysosomal storage disorder called mucolipidosis type IV.

Uniportal VATS Lobectomy for Lung Cancer: Feasibility and Cost Effectiveness in a Single Center Experience

In last decades, video-assisted thoracic surgery (VATS) together with robotic-assisted thoracic surgery (RATS) can be considered the biggest innovation in thoracic surgery. This approach drastically changed the way of performing surgical operations, improving patient’s outcome undergoing thoracic surgery.

Circulating Cell-Free RNA: A New Perspective for Endometrial Cancer

In order to implement the knowledge of cancer to monitor its evolution and setting, in the last decade, new minimally invasive and repeatable samples collection have been developed such as liquid biopsy.

Searching for Easy Reliable Prognostic Parametres in Colorectal Cancer Patients Evaluation

Despite the advances in diagnostic and therapeutic field, colorectal cancer (CRC) still remains the third most common cause of death worldwide, with more than 600,000 cancer-related deaths per year.

Deubiquitinase as Potential Targets for Cancer Immunotherapy

During the last few decades, immunotherapy is considered to be an important approach to help our immune system to fight various kinds of diseases, such as tumor. Sometimes, it works very well for some types of cancers, for example: bladder cancer, colorectal cancer, breast cancer and lymphoma.

Synthetic Lethal Drug Combinations Targeting Proteasome and Histone Deacetylase Inhibitors in TP₅₃-Mutated Cancers

Tumors harboring mutations in certain oncogenes are often dependent on activation of certain pathways which becomes essential for the survival of the cancer cells. This condition is formally known as synthetic lethality, a state when simultaneous loss of two genes is lethal to a cancer cell, while the loss of the individual genes is not.

Role of the Gut Microbiome in the Modulation of Cancer Immunotherapy Response

The gut microbiome or gut flora is a vast community of microorganisms such as bacteria, viruses, protozoa, and fungi that inhabit the digestive tract of the human and other animals [1,2]. In the human body, bacterial species colonize into the oral cavity, skin, vagina, and placenta, however, the largest population of microorganisms resides in the intestine.

Do Support Vector Machines Play a Role in Stratifying Patient Population Based on Cancer Biomarkers

Cancer is a worldwide public health issue that affects millions of people every year. In 2018 there were 17 million newly documented cases of cancer globally (8.8 million in men and 8.2 million in women), leading to 9.6 million deaths. Cancer is a vastly heterogeneous disease, with over 100 different types of cancer currently identified in humans; the most common types of cancer are lung, female breast, bowel and prostate, these four types account for more than 40% of all new cancer case

Prognostic Role of Human Epididymis Protein ₄ (HE₄) in Ovarian Cancer Treatment: Our Point of View

In the last 10 years, the marker “Human Epididymis protein 4 (HE4)” for the management of gynecological tumors has entered powerfully in the world literature. At the moment, carrying out an accurate research in the main scientific portals such as PubMed, we can find more than 2,000 works concerning Cancer antigen-125 (Ca125), but those concerning HE4 are less than 400.

Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy for Breast Cancer

Breast cancer is the second most common cancer worldwide, affecting nearly one in eight women. Accurate cancer staging is essential for determining the patient’s prognosis and for choosing the appropriate treatment.

Platelet Hyperactivity and Dysfunction in Diabetes and Cancer

However, the entire coagulation cascade is dysfunctional, in progressed chronic diabetes and cancer patients.

Development of HPV 16/18 E6 Oncoprotein Paperbased Nanokit for Enhanced Detection of HPV 16/18 E6 Oncoprotein in Cervical Cancer Screening

According to global cancer statistics GLOBOCAN, carcinoma of cervix is ranked as the fourth most common malignancy among women worldwide with an estimation of 570,000 cases and 311,000 deaths in 2018. It is the second most common female malignancy in Lowand- Middle Income Countries (LMICs). In Kenya, the prevalence is 25 cases per 100,000 women. Approximately 75% cases of cervical cancer are caused by persistent infections of the cervical mucosal epithelium with carcinogenic types of human papillomaviruses (HPVs) mainly 16 and 18.

Gastric Cancer: A Brief Review, from Risk Factors to Treatment

Gastric cancer (GC), also known as stomach cancer, is a worldwide health problem. Anatomically, it can occur from the gastroesophageal junction to distal portions of the stomach. Considering both sexes, worldwide, it is the 5th most common neoplasm (5.7%) and the 3rd cause of mortality among malignancies, leading to approximately 782,000 deaths in 2018. The incidence varies geographically but 50% of new cases are diagnosed in developed countries. High incidence is observed in Asia, Latin America, and in the central and eastern parts of Europe. There are several ways to classify GC, but the most used is Lauren’s Classification, which proposes two main histological groups: intestinal and diffuse. This classification is important because there are marked etiological, pathological, and epidemiological differences between the subgroups, guiding the clinical approach for each patient.

Botulinum Toxin: The Promising Future of Prostate Cancer Treatment

Botulinum toxin (BT) is a potent poisonous neurotoxin produced by the bacterium Clostridium botulinum and related species [1]. Its action consists of inhibiting neuromuscular junctions by blocking the release of acetylcholine and desensitizing sensory nerves.

Safety and Efficacy of s-MOX Regimen in Patients with Colorectal Cancer Who Developed Cardiotoxicity Following Fluoropyrimidine Administration: A Case Series

5-fluorouracil (5-FU), an antimetabolite in the fluoropyrimidine class, is the third most commonly used chemotherapeutic agent worldwide for the treatment of solid malignancies [1]. Despite advances in novel cancer therapies, commonly used in combination with fluoropyrimidines, 5-FU remains one of the most effective and safe chemotherapy agents to manage colorectal cancer (CRC).

Surgery Versus Radiation Therapy for Early-Stage Lung Cancer: Patient Selection is Crucial

Lung cancer remains the leading cause of cancer related death in the United States with mortality rates surpassing breast, prostate, brain, and colorectal cancers combined. Recent data shows that susceptibility for both men and women for developing invasive lung and bronchogenic carcinoma peak after the age of 70 years.

Exosome to Promote Cancer Progression via Its Bioactive Cargoes

Exosomes are membranous vesicles ranging in size from 30–100 nm in diameter. They are secreted from multiple cell types into the body fluids through exocytosis, a process commonly used for receptor discharge and intercellular communications.

Genetic Predisposition of Breast Cancer in the United Arab Emirates

This commentary refers to our published article, as highlighted in this article most common gene causing breast cancer in the population living in the United Arab Emirates is BRCA2 followed by BRCA1. This is the first publication discussing about clinical and pathological features of breast cancer in woman with a positive genetic mutation in the United Arab Emirates.

Journal of Cancer Immunology

2023

Recommended Articles

Trending Special Issues

T cell Exhaustion in Cancer

About Scientific Archives