Journal of Cancer Immunology

Commentary Open Access

TFAP-2: A Special Regulator with Bidirectional Effect in Human Cancer

Li-Nan Wang, Yi-Liu Yang, Lin-Yong Zhao

Abnormality of transcription factors’ activity has been found in signal pathways of many cancers. The AP-2 family of transcription factors (TFAP2) is one of the most representative families with this characteristic.

Commentary Open Access

Long Non-coding RNAs in the Pathophysiology of Multiple Myeloma New Insights on the Role of CRNDE

Simone Zocchi, Antoine David, Michele Goodhardt, David Garrick

Over the past 15 years, long non-coding RNAs (lncRNA) have emerged as an important class of regulatory molecules. The currently accepted definition is that lncRNA refers to RNA molecules with little or no protein-coding potential, and which are greater than 200 nucleotides in length, a size cut-off chosen largely to distinguish them from the more-extensively characterised group of small non-coding regulatory RNAs, which includes micro (mi)RNAs, small inhibitory (si)RNAs and PIWI-interacting (pi)RNAs.

Commentary Open Access

Small-molecule Interferon Inducers for Cancer Immunotherapy Targeting Non-T cell-inflamed Tumors

Eunha Kim, Sanghee Lee

Since the discovery of escaping mechanism of tumor from negative immune regulation, the paradigm of drug discovery for anti-cancer agents has been dramatically shifted to cancer immunotherapy (e.g., dendritic cell therapy, CAR-T cell therapy, or antibody therapy) by stimulating patient’s immune system to treat cancer. 

Review Article Open Access

SHP₂ Inhibition as a Promising Anti-cancer Therapy: Function in Tumor Cell Signaling and Immune Modulation

Jiawan Wang, Lindy Zhang, Christine A. Pratilas, Nicolas J. Llosa

The SHP2 phosphatase consists of one protein tyrosine phosphatase catalytic domain (PTP domain), two tandem Src homology 2 (SH2) domains (N-SH2 and C-SH2), and a C-terminal tail with two tyrosine phosphorylation sites (Tyr542 and Tyr580)

Commentary Open Access

Expanding the Cancer Neoantigen Peptide Repertoire beyond In silico Tools

Amit Jain, Jackwee Lim

CD8+ cytotoxic T cells recognise and kill cancer cells that present immunogenic peptides bound to the cell surface major histocompatibility complex class I (MHC-I) molecules.

Commentary Open Access

Lenalidomide Maintenance After Autologous Stem Cell Transplant: The Utility of Real-World Data and Future Areas of Study

Hannah M Cherniawsky, Christopher P Venner, Esther Masih-Khan, Donna Reece

Low-dose, lenalidomide maintenance following autologous stem cell transplantation (ASCT) is the current standard of care in patients with newly diagnosed multiple myeloma (NDMM) based on results from large, randomized controlled trials and a meta-analysis which demonstrated improved overall (OS) and progressionfree survival (PFS).

Review Article Open Access

Immunogenic Cell Death: A Step Ahead of Autophagy in Cancer Therapy

Gourab Gupta, Kristina Borglum, Hexin Chen

Cell Death has long been considered to be an inevitable part of the life cycle of a cell and hence, considered a familiar consequence of cellular life.

Commentary Open Access

Hepatocellular Carcinoma: Diagnosis, Therapy and Molecular Investigations

Veronica Bazzani, Riccardo Pravisani, Umberto Baccarani, Carlo Vascotto

Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancers and, with rapidly increasing incidence in the last two decades, constitutes a major global health problem.