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Archives of Obstetrics and Gynaecology

ISSN: 2692-787X

Review Article Open Access

Bacterial Profile and Drug Resistance Patterns among Pregnant Women with Bacteriuria in East Africa: A Systematic Review and Meta Analysis

Molla Getie Mehari1,*, Mekdes Molla2
  • 1Injibara University, College of Medicine and Health Sciences, Department of Medical Laboratory Science, Injibara, Ethiopia
  • 2Department of Midwifery, College of Medicine and Health Sciences, Samara University, Samara, Ethiopia
+ Affiliations - Affiliations

Corresponding Author

Molla Getie Mehari, mollagetie2006@gmail.com

Received Date: October 03, 2024

Accepted Date: July 31, 2025

Citation:

Mehari MG, Molla M. Bacterial Profile and Drug Resistance Patterns among Pregnant Women with Bacteriuria in East Africa: A Systematic Review and Meta Analysis. Arch Obstet Gynecol. 2025;6(2):66–81.


Copyright: © 2025 Mehari MG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Due mostly to the growth of multidrug resistant infections, antimicrobial resistance (AMR) has limited the arsenal of medical professionals against infectious diseases on a global scale. Thus, the purpose of this systematic review and meta-analysis is to present the pooled prevalence, bacterial profile, and current trend of antibiotic resistance in pregnant women who have significant bacteriuria in East Africa.

Methods: The current review covers every full-text publication in English language that is available (without date constraints) and is indexed in main scientific databases: Google Scholar, HINARI, PubMed, Science citation, and the Cochrane library. Studies of populations residing in East African countries reporting the prevalence of significant bacteriuria, bacterial profile and Drug resistance patterns were included. The data were extracted using the extraction form prepared in Microsoft Excel and exported to STATA 14.0 software for the outcome measure analyses and subgrouping.

Results: 8 articles were met the inclusion criteria selected for this systematic review and meta-analysis with 2,611 total enrolled participants and 405 Significant bacteriuria. The pooled prevalence of Significant bacteriuria among pregnant women in East Africa is found to be 16.79% (95% CI; 11,11–22.47; I2=94,98%; p<0.001) with substantial heterogeneity. The first most common bacterial isolate was Escherichia coli. The pooled incidence of Escherichia coli recovered from isolates of 405 urine samples was 43% (95% CI 37–48%). Multidrug resistance proportions of all isolates was 91% (95% CI 74–100%).

Conclusion: This meta analysis's findings indicated that pregnant women in the East Africa had substantial bacteriuria. The overall observed MDR were High. Due to the high prevalence of drug resistance, it is necessary to conduct frequent epidemiological surveillance for antibiotic resistance and to put in place an effective program for infection control and stewardship.

Keywords

Antimicrobial resistance, East Africa, Pregnant women, Meta-analysis, Significant bacteriuria, Urinary tract infection

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