Journal of Diabetes and Clinical Research

Commentary Open Access

Plasma Non-Esterified Fatty Acids (NEFA) in Type 2 Diabetes Mellitus: Evidence on Pathophysiology

Kailash Chandra , Vineet Jain , Swatantra Kumar Jain

Type 2 diabetes mellitus (T2DM) is a metabolic dysfunction characterized by elevated levels of blood glucose as well as impaired lipid and protein metabolism. The mobilization of fatty acids is augmented in insulin resistance due to the failure of lipolysis inhibition by the hormone that further augments the increase in plasma NEFA levels.

Commentary Open Access

Vitamin D and Insulin Resistance in Polycystic Ovarian Syndrome and Congenital Adrenal Hyperplasia-a Commentary and Natural Expansion

Alan Sacerdote

In our previous focused review, the journal emphasized Type 2 diabetes (T2DM), excluding intimately associated disorders that should be considered integral components of the insulin resistance (IR) syndrome e.g., polycystic ovarian syndrome (PCOS), congenital adrenal hyperplasia (CAH), and gout.

Commentary Open Access

Validation of a New Test for Assessing the Quality of Life Perceived in Patients with Type 1 Diabetes

Pala L , Cosentino C , Acciaioli S , Dicembrini I , Lazzeretti L , Rotella F , Mannucci E

The World Health Organization defines quality of life (QoL) as “the perception that an individual has of his life, in the context of the culture in which he lives, integrating personal goals, expectations and concerns, well-being and discomfort”.

Research Article Open Access

Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device

Robert S. Kellar , Robert B. Diller , Aaron J. Tabor , Dominic D. Dominguez , Robert G. Audet , Tatum A. Bardsley , Alyssa J. Talbert , Nathan D. Cruz , Alison L. Ingraldi , Burt D. Ensley

Chronic, non-healing, or slow to heal wounds present a significant and growing health problem in the United States, with an estimated 6.5 million people affected, at an annual cost of US $20 billion, with the highest risk groups represented by the elderly and the increasing prevalence of lifestyle diseases such as diabetes and obesity.

Mini Review Open Access

Risks and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Rebecca Louise Thomas , Sze May Ng

Type 1 diabetes (T1D) is associated with microvascular and macrovascular complications.Duration of diabetes, poor glycaemic control, high blood pressure and proteinuria are reported risk factors contributing to the development of diabetes related complications.

Commentary Open Access

Can Vitamin D Supplementation Reduce Insulin Resistance and Hence the Risks of Type 2 Diabetes?

Barbara J Boucher

The question of whether or not correction of vitamin D deficiency might reduce the risks of later type 2 diabetes mellitus (T2DM) has been under debate for many decades. The necessity of vitamin D for normal insulin secretion was first identified experimentally in the 1980s.

Review Article Open Access

The Diabetic Shoulder – A Literature Review

Sana’a A. Alsubheen , Joy C. MacDermid , Tom J. Overend , Kenneth J. Faber

The shoulder complex is composed of three bony structures: the clavicle, scapula, and humerus, which are connected to form three synovial (glenohumeral, acromioclavicular, and sternoclavicular) and two functional (scapulothoracic and subacromial) joints.

Research Article Open Access

Altered Peak C-peptide and Fasting Blood Glucose in Children with Autism Spectrum Disorder

Mengxiang Zhang , Rui Ding , Zuqun Wang , Juan Zhang , Jing Liu , Juan Wang

ASD refers to a group of complex neurodevelopmental disorders, characterized by deficits in social communication, interaction and demonstrating restricted, repetitive, and stereotyped patterns of behavior. Centers for Disease Control and Prevention forecasted that the prevalence of ASD would be 1 in 45 in USA.