Archives of Clinical Ophthalmology

Original Research Open Access

Repeatability of Scheimpflug Corneal Tomography in Patients with Keratoconus and Different Body Mass Indices

James S Lewis , Lize Angelo , Akilesh Gokul , Charles NJ McGhee , Mohammed Ziaei

To evaluate the repeatability of corneal tomographic parameters in keratoconus patients across different body mass index (BMI) categories. This prospective study was conducted at the University of Auckland, New Zealand, from June 2021 to June 2022. A total of 243 eyes from keratoconus patients aged 18-45 years were categorized into normal (BMI ≤24.9; n=55), overweight (BMI 25.0-29.9; n=58), and obese (BMI ≥30.0; n=130) groups. Patients underwent three consecutive scans using the Pentacam AXL.

Review Article Open Access

Lens Clarity and Visual Fatigue in Children: The Role of Eyewear Hygiene and Healthcare Professionals

Mirela Tushe

Visual fatigue, also known as digital eye strain (DES), has become a growing concern among children due to increased exposure to digital screens, especially after the global shift to remote learning during the COVID-19 pandemic. Although prolonged screen time and poor ergonomics are well-recognized contributors, the influence of eyewear hygiene-specifically lens cleanliness-on visual discomfort is less explored.

Commentary Open Access

Gabapentin for Ocular Surface Disorders: Bridging Molecular Mechanisms to Therapeutic Innovation 

Caterina Gagliano , Alessandro Avitabile , Dario Rusciano

This commentary critically evaluates Rusciano's (2024) comprehensive review on gabapentin (GBP) as a multifaceted therapy for ocular surface diseases, emphasizing its transition from systemic to topical applications. We highlight the review's synthesis of GBP's polypharmacology—spanning calcium channel modulation, anti-inflammatory effects, and neuroprotection—and its innovative integration with nanotechnology (e.g., nanoceria platforms) to overcome corneal delivery challenges while potentially reducing systemic side effects associated with oral administration.

Original Research Open Access

Treatment Burden Associated with Intravitreal Injections: A Cross-sectional Study at a Tertiary Eye Centre in Ireland

Ann Marie O’Leary , Daniel Coakley , Eamonn O’Connell

Treatment burden significantly impacts patient adherence and quality of life when it comes to chronic conditions requiring frequent medical interventions. Intravitreal injections are administered to over 20 million patients globally annually, yet the associated treatment burden remains poorly quantified in Irish healthcare settings. This study aimed to assess treatment burden and identify key predictors among patients receiving intravitreal injections for retinal conditions at a tertiary eye center in Ireland.

Literature Review Open Access

Advances in Inflammatory Biomarkers for Diabetic Retinopathy 

Honghong Dong , Ying Xie

Diabetic retinopathy is a leading cause of blindness in diabetic patients, and its onset and progression are influenced by inflammation. This article provides an overview of local inflammatory biomarker research in diabetic retinopathy, covering serum, aqueous humor, vitreous inflammatory factors, and retinal inflammation markers. Through a systematic review and analysis, we found that inflammatory biomarkers play a crucial role in the prediction, diagnosis, and treatment of diabetic retinopathy, as well as in understanding its pathological mechanisms and improving clinical diagnostic and therapeutic strategies.