Commentary - Journal of Experimental Neurology (2021) Volume 2, Issue 3
Impact of Cellular Senescence on Neurodegenerative Diseases during the COVID-19 Pandemic: Suitable Targets Required to Eliminate Cellular Senescence
Md Mohiuddin*, Kazuo Kasahara
Department of Respiratory Medicine, Kanazawa University, Ishikawa, Japan
- *Corresponding Author:
- Md Mohiuddin
Received date: August 14, 2021; Accepted date: September 24, 2021
Citation: Mohiuddin M, Kasahara K. Impact of Cellular Senescence on Neurodegenerative Diseases during the COVID-19
Pandemic: Suitable Targets Required to Eliminate Cellular Senescence. J Exp Neurol. 2021;2(3):140-142.
Copyright: © 2021 Mohiuddin M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We recently reviewed the scientific literature that elucidates the impact of cellular senescence on COVID-19 complications . Recent studies have discussed the association of cellular senescence in COVID-19 patients with neurodegenerative diseases [2-5]. Therefore, in the present study, we extend this scientific synopsis to comment on how cellular senescence can promote neurodegenerative diseases and to describe suitable targets for eliminating cellular senescence.
Cellular senescence is a phenomenon characterized by a stable and terminal stage of growth arrest . During cellular senescence, phenotypic changes can occur, known as senescence-associated secretory phenotype (SASP) . Persistent senescent cells cause age-related diseases, while the induction of acute senescence protects against cancer . Thus, targeting senescent cells to limit cellular aging by administering appropriate drugs—called senolytics— could effectively remove senescent cells .
The induction of cellular senescence is regulated by excessive ROS production . In contrast, high ROS levels can mediate the activation of p53, which triggers the activation of autophagy . This cellular process triggers mitochondrial dysfunction, which is related to the induction of cellular senescence . ROS have been reported to alter various cellular functions through DNA damage, promoting certain human diseases, such as cancer and neurodegenerative disease . Thus, the implementation of ROS production inhibitors to maintain a correct ROS balance could reduce cellular senescence.
Peripheral immune cells, astrocytes, microglia, and neurons can secrete cytokine molecules into the central nervous system (CNS) . The upregulation of cytokines and their receptors in the brain is characterized as
peripheral or central inflammation . Inflammation
has been reported to play an important role in the central
nervous system for various neurodegenerative diseases,
including Parkinson’s disease and Alzheimer’s disease
[15,16]. Notably, interleukin (IL)-6, a pro-inflammatory
cytokine, is elevated in patients with Alzheimer’s disease
. In addition, β-amyloid (Aβ) peptide deposition
promotes a spectrum of activated microglia-mediated
brain neuroinflammation, causing the expression of
various inflammatory cytokines, including IL-6, tumor
necrosis factor-α (TNF-α) and IL-1β . Conversely, proinflammatory
cytokines, such as IL-6 and IL-8 are also
present in SASP ; therefore, cytokine inhibitors could
be useful in targeting and eliminating cellular senescence.
NF-κB is a transcription factor involved in the control of a large number of cellular processes, including cell survival, immune and inflammatory responses, and apoptosis . NF-κB has been reported to be activated by cell damage and stress, resulting in increased activity with chronic aging-related diseases . Furthermore, NF-κB signaling is the main inducer of cellular senescence . Aging is the most significant risk factor for the development of Alzheimer’s disease, and recent findings have shown tissue-specific brain inflammation mediated by NF-κB in Alzheimer’s disease [22,23]. Therefore, inhibition of the NF-κB pathway could be a suitable approach to eliminating cellular senescence and targeting the onset of AD.
mTOR is a member of the phosphatidylinositol 3-kinase family of protein kinases . mTOR binds to other proteins and serves as a central component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes . Mammalian target of rapamycin complex 1 (mTORC1) and cellular
senescence have been reported to be closely related to each
other and to organism aging . Furthermore, mTOR
regulates cellular senescence by modulating mitochondrial
metabolism, autophagy, and protein translation . A
previous study claimed that mTOR plays a role in several
neurodegenerative diseases, including Down syndrome,
Alzheimer’s disease, and Huntington’s disease .
Therefore, mTOR inhibition could be a suitable strategy
for eliminating cellular senescence.
In conclusion, emerging evidence has demonstrated that cellular senescence is related to neurodegenerative diseases. Furthermore, preliminary studies have indicated that cellular senescence could exacerbate the complications of COVID-19. Due to the COVID-19 pandemic, limited preclinical and clinical studies have investigated the impact of cellular senescence on complications of COVID-19 in patients with neurodegenerative disorders. However, we anticipate that there will soon be greater efforts to fully establish the role of cellular senescence in COVID-19 patients with neurodegenerative disease.
All authors have accepted responsibility for the entire
content of this manuscript and approved its submission.
The authors declare no conflicts of interest in association
with the present study.
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