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Commentary Open Access
Volume 4 | Issue 6 | DOI: https://doi.org/10.33696/immunology.4.153

Vγ2+ γδ T Cells and Their Regulatory Potential in Skin Allograft Survival

  • 1National Centre for Cell Science, SP Pune University Campus, Ganeshkhind, Pune, MH-411007, India
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Corresponding Author

Girdhari Lal, glal@nccs.res.in

Received Date: August 09, 2022

Accepted Date: December 13, 2022

Abstract

Our recently published research article “Vγ2+ γδ T cells in the presence of anti-CD40L control surgical inflammation and promote skin allograft survival” revealed that the Vγ2+ subset of γδ T cells, which otherwise are known primarily for its proinflammatory function, regulate the survival of skin allografts in the presence of anti-CD40L. Upon depletion of Vγ2+ γδ T cells, tolerogen DST (donor-specific transfusion) plus anti-CD40L induced skin allograft survival was significantly reduced. Tolerogen treatment increased the frequency of CD39+Vγ2+ regulatory γδ T cells and suppressed IFN-γ-producing effector Vγ2+ γδ T cells in the spleen and allograft. Tolerized Vγ2+ γδ T cells inhibited differentiation of inflammatory T helper type 1 (Th1) cells. Furthermore, the adoptive transfer of regulatory Vγ2+ γδ T cells prolonged the survival of allografts in untreated wild-type and TCRδ-/- mice. Our study highlights the critical role γδ T cells in transplant tolerance and paves the way for future research toward exploring regulatory γδ T cells.

Keywords

Gamma-delta T cells, Transplantation Tolerance, Co-stimulation, Allograft, Surgery

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