Archives of Pharmacology and Therapeutics

Research Article Open Access

Relative COVID-19 Vaccine Booster Effectiveness and ClinicalEpidemiological Characteristics Before and After 29 Days of Shot

Jose Luis Turabian

Background: When the highest vaccine COVID-19 booster effectiveness (VBE) is obtained is not clearly known. Objective: To compare the cases of COVID-19 in booster vaccinated people with a time of <29 days vs. ≥ 29 days from booster to infection diagnosis and assess their relative VBE. Methodology: An observational, longitudinal and prospective case series study of adult patients with COVID-19 breakthrough infections in booster vaccinated people, in general medicine and for the period December 2021 to February 2022, during the omicron variant contagion wave.

Review Article Open Access

Pharmacologic Therapies for Non-Muscle Invasive Bladder Cancer: Current and Future Treatments

Ilana P. Goldberg MD, Benjamin Lichtbroun , Eric A. Singer , Saum Ghodoussipour

Bladder cancer is the sixth most common malignancy in the United States and 70% of cases are non-muscle invasive at the time of diagnosis. Effective treatment is crucial to prevent progression, which occurs in about 30% of patients. The American Urological Association (AUA) guidelines recommend treatment of non-muscle invasive bladder cancer (NMIBC) with intravesical Bacille Calmette-Guerin (BCG) and chemotherapy.

Commentary Open Access

Is There a Simple and Easy Way to Detect Singlet Oxygen? Comparison of Methods for Detecting Singlet Oxygen and Application to Measure Scavenging Activity of Various Compounds

Tokuko Takajo, Kazunori Anzai

Reactive oxygen species (ROS) are known to exert both beneficial and harmful effects in the human body. Singlet oxygen (1O2), is highly reactive and considered as one of the ROS, although it is not a radical molecule.

Commentary Open Access

Artificial Intelligence in Pharma: Positive Trends but More Investment Needed to Drive a Transformation

Peter Henstock

Over the past few years, pharmaceutical R&D has become aware of the potential benefits of leveraging artificial intelligence and its collective subfields including machine learning, deep learning, data science and advanced analytics.

Commentary Open Access

Beta-Sitosterol: As Immunostimulant, Antioxidant and Inhibitor of SARS-CoV-2 Spike Glycoprotein

Sharuk L. Khan, Falak A. Siddiqui

This article is an extension to our recently published article in Asian Journal of Pharmaceutical and Clinical Research, entitled “Β-Sitosterol: Isolation from Muntingia Calabura Linn. Bark Extract, Structural Elucidation, and Molecular Docking Studies as Potential Inhibitor of SARSCoV-2 Mpro (COVID-19)”[1].

Editorial Open Access

Diverse Therapeutic Applications of Onion

Preetismita Borah, Bimal Krishna Banik

Onion has been a very useful vegetable for human. The organic molecules present in onion are extremely diverse and exert numerous pharmacological pathways to prevent diseases