Archives of Medical Case Reports

Case Report Open Access

Imatinib Induced Hypopigmentation and Neutropenia in a Patient with Gastric Gastrointestinal Stromal Tumor

Kevin Y Wang, Jeffrey Chi, Muhammad Wasif Saif

Imatinib is a selective inhibitor of the bcr-abl tyrosine kinase making it a potential treatment of chronic myelogenous leukemia (CML), as well as a selective inhibitor of KIT protein tyrosine kinase, and PDGF receptor, and is the treatment of choice in patients with gastrointestinal stromal tumors (GISTs)

Case Report Open Access

Cortical Visual Impairment (CVI): An Atypical Manifestation of Osmotic Demyelination Syndrome in a Child

Najm Khan, Rahul Lakshmanan, Snehal Shah, Lakshmi Nagarajan

Osmotic Demyelination Syndrome (ODS) is a unique process of selective demyelination and destruction of oligodendrocytes and astrocytes in specific areas of the brain that usually occurs a few days after an osmotic stress [1]. ODS has been described most frequently in association with a rapid correction of hyponatremia, though it may occur with other electrolyte or metabolic abnormalities.

Case Report Open Access

Pseudothrombocytosis Due to Red Blood Cell Fragmentation in Haemoglobin-H Disease

Raja Zahratul Azma, Sarah Noor, Maryam Ahmad

Red cell membrane in patients with haemoglobin H (Hb-H) disease and other haemoglobinopathies is rigid and thus red blood cells are fragmented during passage through narrow capillary beds, especially through the splenic sinusoids and the liver [1,2]. These fragments are frequently seen in peripheral blood films.

Case Series Open Access

Safety and Efficacy of s-MOX Regimen in Patients with Colorectal Cancer Who Developed Cardiotoxicity Following Fluoropyrimidine Administration: A Case Series

Matthew I. Ehrlich, Kristin Kaley, Melissa Smith, Muhammad Wasif Saif

5-fluorouracil (5-FU), an antimetabolite in the fluoropyrimidine class, is the third most commonly used chemotherapeutic agent worldwide for the treatment of solid malignancies [1]. Despite advances in novel cancer therapies, commonly used in combination with fluoropyrimidines, 5-FU remains one of the most effective and safe chemotherapy agents to manage colorectal cancer (CRC).

Case Report Open Access

Healthy Fetal Outcomes Using A Novel Treatment For Maternal Lyme Disease And Babesiosis During Consecutive Pregnancies: A Case Study and Literature Review

Richard Horowitz, Phyllis R. Freeman

The genus Babesia comprises over 100 species of tick-transmitted protozoal intraerythrocytic pathogens (piroplasms) [1], causing malarial-type illness. The most common human pathogens in the United States are B. microti [2] and Babesia duncani (WA- 1) [3]; Less common species include Babesia MO-1 [4] and KO-1 [5], as well as Babesia divergens and Babesia venatorum (EU-1) in Europe.