Case Report Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.33696/casereports.3.012

Pseudothrombocytosis Due to Red Blood Cell Fragmentation in Haemoglobin-H Disease

  • 1Department of Pathology and Clinical laboratory, French Medical Institute for Mothers and Children, Kabul Afghanistan
  • 2Department of Pathology and Laboratory Medicine, The National University of Malaysia, Kuala Lumpur Malaysia
  • 3Department of Haemato-Oncology, Jumhoriat Hospital, Kabul Afghanistan
+ Affiliations - Affiliations

Corresponding Author

Ahmed Maseh Haidary, ahmedmaseh.haidary@fmic.org.af

Received Date: September 14, 2021

Accepted Date: September 22, 2021


Introduction: Red cell fragmentation may result in erroneously high platelet counts by automated blood counters. Therefore, any abnormal platelet counts in a full blood count analysis should be re-evaluated either using blood film manual counting or with more accurate automated analysis options. Case Report: We report a case of Haemoglobin-H disease that was noted to have a very high platelet count, by newly installed automated blood analyser, during regular follow up. Manual platelet counts and the automated analysis using flowcytometric counting of the same analyser showed a normal platelet count. Conclusion: A wide spectrum of blood disorders can cause pseudothrombocytosis. Whenever an unexpected high platelet count is encountered, alternative modalities should be used to confirm the actual platelet count such as manual count on a blood film. Furthermore, machines using the impedance principle need to be calibrated to reduce the chances of getting abnormal results with actual normal platelet counts.



Pseudothrombocytosis, Red cell fragmentation, Hb-H disease

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