Volume 4, Issue 1, p1-40
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Incidence of Nephrotoxicity among People Living with Human Immunodeficiency Virus on Tenofovir Treatment in a Tertiary Hospital in the Philippines
Tenofovir disoproxil fumarate (TDF) is one of the main antiretroviral drugs of people living with human immunodeficiency virus (PLWHIV). Despite its efficacy and tolerability, there is conflicting evidence regarding TDF-associated nephrotoxicity, which is proposed to cause injury by accumulation of tenofovir (TFV) within proximal tubular cells leading to mitochondrial injury and tissue hypoxia.J AIDS HIV Treat, 2022, Volume 4, Issue 1, p1-5 | DOI: 10.33696/AIDS.4.025
Pregnancy Outcomes in Pregnant Women with HIV on Tenofovir Disoproxil Fumarate (TDF) Compared to Tenofovir Alafenamide (TAF)
HIV infection in pregnancy continues to be of significant clinical and public health importance [1,2]. The current statistics published by the World Health Organization (WHO) demonstrate that 38 million people are living with HIV in 2019, and 1.1 million (85%) pregnant women living with HIV received antiretroviral therapy (ARVs) during pregnancy and postpartum.J AIDS HIV Treat, 2022, Volume 4, Issue 1, p6-13 | DOI: 10.33696/AIDS.4.026
In spite of all efforts to reduce transmission of HIV-1, 1.7 million persons were infected in 2019 worldwide. Whereas in the developed countries the COVID-19 pandemic is reasonably controlled within 2 years because of the fast and successful development of vaccines, nearly 40 years after the first reported cases of AIDS due to HIV-1 and in spite of tremendous efforts to develop vaccines against HIV-1, there are still no vaccines against the virus.J AIDS HIV Treat, 2022, Volume 4, Issue 1, p14-21 | DOI: 10.33696/AIDS.4.027
Tenofovir Alafenamide, Emtricitabine, and Bictegravir in Switch Strategy for HIV-1 Adult Patients Due to Previous Renal Impairment Induced by Tenofovir Disoproxil Fumarate
Non-AIDS comorbidities, metabolic, renal and bone toxicities associated to combined antiretroviral therapy (cART), namely NRTIs, led to dual therapy (NUC sparing regimens). Tenofovir Alafenamide Fumarate (TAF) demonstrated improved renal and bone safety profile over TDF even with mild to moderate renal impairment.J AIDS HIV Treat, 2022, Volume 4, Issue 1, p22-29 | DOI: 10.33696/AIDS.4.028
Patient Satisfaction and Perceptions Regarding Anti-Retroviral Therapy (ART) Services in Rural Southwestern Uganda
Patient satisfaction and perception of the healthcare services received contribute to compliance with treatment guidelines, retention in care, and adherence to recommendations. This is especially so in the treatment of chronic medical conditions such as HIV/AIDS. The success of antiretroviral therapy (ART) plays a fundamental role in determining the quality of life of people living with HIV/AIDS (PLWHAs).J AIDS HIV Treat, 2022, Volume 4, Issue 1, p30-40 | DOI: 10.33696/AIDS.4.029
Low-level Progesterone on the Day of hCG Injection Has No Detrimental Effect on the Pregnancy Outcome after IVF with GnRH-a Protocol: A Retrospective Study
To investigate the effect of low progesterone (P) level on the day of human chorionic gonadotropin (hCG) injection on the outcome of in vitro fertilization (IVF) with GnRH- agonist (GnRH-a) long protocol.
Chronic hypertension is present in 1-2% of pregnant women. Women with chronic hypertension are at an increased risk of maternal and perinatal complications when compared with normotensive women.
For a long time, it was rare to see a case of cervical pregnancy (CP) throughout the journey in the field of obstetrics. Recently, the circumstances showed dramatic changes and I think not uncommonly every one elsewhere in the field may face this problem to some extent and the CP term strikes his/her ears.
Tenofovir, alias (R)-PMPA, was first divulged as an anti- HIV agent in 1993 . That it would in 2012, become the first antiretroviral agent, approved by the US FDA (Food and Drug Administration) to prevent HIV infection, could have been predicted from the findings of Tsai et al.
Adnexal Torsion During the Second Trimester of Pregnancy: Mc Burney Incision and Management Strategy
A 33-year-old pregnant woman at 26 weeks gestation presented with abdominal pain in the right iliac fossa. She had a history of a left ovarian cyst. The current pregnancy was normal. The patient was apyretic.
Pregnancy and Hepatitis B Immunization: A Commentary on Maternal Knowledge and Vertical Transmission Risks
The paper Maternal knowledge of the risk of vertical transmission and offspring acquisition of hepatitis B, recently published in Annals of Hepatology, provides unique insight on a topic not previously studied in the USA. The research paper discusses important topics on maternal hepatitis B infections.
As the new editor-in-chief of Archives of Gastroenterology Research (AGR) I cordially welcome all current readers of AGR and future contributors to AGR. Together with my editorial team of AGR we encourage scientists and clinicians involved in the care of patients with gastrointestinal diseases to submit their interesting reports to AGR with the aim to be published following fair evaluation by external peer reviewers
Primary Lymph Node Kaposi's Sarcoma in Two HIV Positive Patients Presenting with Generalized Lymphadenopathy and Pancytopenia in a Third Level Hospital in Guatemala
We present two unique cases in which two HIV positive patients with generalized lymphadenopathy and pancytopenia without any skin lesions were diagnosed with primary lymph node Kaposi´s Sarcoma after excisional biopsy of an inguinal lymph node.
Cellular components are attractive targets for antiviral therapy because they do not mutate as readily as do viral proteins do [1-3]. The identification of CCR5 as an HIV-1 coreceptor [4-7], facilitated by the discovery of the antiviral activities of CCR5 ligand ?-chemokines , resulted in the development of new viral entry inhibitors to block CCR5 binding, including both- small molecules and CCR5 antibodies
Since isolation in humans in 1983 [1,2], HIV-1 has developed into a global pandemic. But an effective HIV-1 vaccine has not been succeeded despite multiple human vaccine trials performed [3,4]. Challenges to an effective vaccine arise from intrinsic virological and immunological features of HIV-1 [3-8].
Anti-HIV-1 Activity of Crocodylus mindorensis (Philippine Crocodile) Serum in Cell-free and Cell-associated Virus Interactions to Human Peripheral Blood Mononuclear Cells
Highly-Active Antiretroviral Therapy (HAART) is the recommended treatment and management strategy for HIV infection. Although the existing antiretroviral drugs are indispensably significant in improving the quality and extending the lives of HIV/ AIDS individuals, the drugs still have many limitations including development of resistance, production of toxicity, and their limited availability.
Assessment of Attitudes toward HIV and AIDS among Undergraduate Students at a Historically Black University
HIV is no longer only a public health challenge, but also a global threat with a devastating negative impact that has claimed over 35 million lives globally. In 2017, about 36.9 million people live with HIV, and 1.8 million people becoming newly infected with the disease globally .
Health Workers’ Perspectives on the Outcomes, Enablers, and Barriers to the Implementation of HIV “Test and Treat” Guidelines in Abuja, Nigeria
HIV/AIDS continues to be a major public health disease accounting for 35 million deaths across the world. In 2016 alone, there were 1.8 million new HIV infections and 1 million deaths worldwide.
For more than 35 years, the world has grappled with an AIDS epidemic that has claimed an estimated 35.0 million [28.9 million-41.5 million] lives and at its peak threatened global stability and security.
Development of an Ultrasensitive HIV-1 DNA Detection Assay Based on an Automated πCode End-Point PCR System
Currently, around 60-75% of the HIV positive patients in developed countries on anti-retroviral therapy (ART) have undetectable plasma viral load using current diagnostic PCR assays.
Patient-Reported Health Outcomes among HIV-Infected Patients on Antiretroviral Therapy in a Tertiary Hospital in Dar Es Salaam, Tanzania: A Cross Sectional Study
The use of antiretroviral therapy (ART) has resulted into HIV-infected patients living longer than it was the case in the pre-ART era . Surviving patients are concerned not only with the treatment ability to extend their lives but also that their quality of life is improved on the course.
After thousands of years of gender conflicts, the world now stands at the beginning of the feminine era, when women will rise to their proper standing, and the entire world will experience the harmony between men and women.
Different humanized mouse models have been introduced to enable HIV-1 research in vivo, which has been made possible by the development of immunodeficient mouse strains.
Metabolic Syndrome in HIV Infected Children Receiving Free HAART at a Centre of Excellence in HIV Care in Northern India
Implementation of Highly Active Antiretroviral Therapy (HAART) for patients with HIV has led to the dramatic reduction in AIDS related mortality in both children and adults . With their longer life expectancy and improved quality of life, effects of ageing and other environmental factors are predisposing them to non-AIDS related morbidities, with cardiovascular diseases emerging as an important threat.
Unveiling an Atypical Response to HIV-1 Infection by the Patient Carrier of the Beta-S Globin Gene and Duffy Antigen Gene Double Mutation
It is known and well documented that genetic selective pressures occur from Plasmodium falciparum, P. vivax or P. knowlesi infection of red blood cells, such led to the selection of their cell membrane antigens, hemoglobin and enzymes thus associated to several mutation including, among others.
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