Commentary Open Access
Volume 8 | Issue 1 | DOI: https://doi.org/10.33696/immunology.8.250
TGFα as a Damage-Limiting Signal Preserving Tissue Integrity
Julia Zissler1, Lena Lößlein2, Friederike Zunke3, Veit Rothhammer1,4,*
- 1Department of Neurology, University Hospital Erlangen, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany
- 2Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates
- 3Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany
- 4Deutsches Zentrum Immuntherapie, University Hospital Erlangen, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany
Corresponding Author
Veit Rothhammer, veit.rothhammer@uk-erlangen.de
Received Date: February 23, 2026
Accepted Date: April 07, 2026
Zissler J, Lößlein L, Zunke F, Rothhammer V. TGFα as a Damage-limiting Signal Preserving Tissue Integrity. J Cell Immunol. 2026;8(1):25–29.
Copyright: © 2026 Zissler J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recommended Articles
Exercise Benefits on Alzheimer’s Disease
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder [1] and the most common cause of human dementia, accounting for approximately 60%?80% of cases. It is estimated that more than 30 million AD patients, and the number likely to increase to over 100 million by 2050 because of the increase of the elderly population [2].
Effect of Exosomes on Alzheimer’s Disease
AD is a neurodegenerative disease characterized by progressive cognitive impairment, behavioral changes, memory loss and executive dysfunction, all of which present serious threats to the health of older people.
Effects of a CB2 Subtype Selective Agonist ABK5-1 on Cytokine Production in Microglia
Neuroinflammation is closely associated with various diseases including neuropathic pain. Microglia are immune cells in the central nervous system which are the main players of immunity and inflammation. Since microglia are activated by nerve injury, and they produce proinflammatory mediators to cause neuropathic pain, targeting activated microglia is considered to be a strategy for treating neuropathic pain.
Cutaneous Side Effects of First-Second Line Oral Disease - Modifying Treatments in Patients with Multiple Sclerosis
Multiple sclerosis (MS) is a progressive autoimmune and sometimes disabling disease of the central nervous system (CNS), characterized by formation of white matter lesions in the CNS due to inflammation, demyelination and axonal loss [1-3].
Is Cellular Senescence of Dopaminergic Neurons the Cause of Local Inflammation in the Midbrain Observed in Parkinson’s Disease?
Current research investigating the pathomechanisms of neurodegenerative disorders of the central nervous system (CNS), such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), or Parkinson’s disease (PD), led to the understanding that these diseases have to be seen in the context of immune responses. In other words, inflammation plays a central role in neurodegenerative disorders of the CNS.