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Review Article Open Access
Volume 5 | Issue 4 | DOI: https://doi.org/10.33696/Signaling.5.124

Obesity Significantly Modifies Signaling Pathways Associated with Bone Remodeling and Metabolism

  • 1Sanctuary International Visitor Support Scheme, Sheffield, UK
  • 2Division of Clinical Medicine, School of Medicine and Population Health, Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield, UK
  • 3MRC Versus Arthritis Centre for Iintegrated research in Musculoskeletal Ageing (CIMA), Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield, UK
  • 4100. Yil Private Hospital, Ankara, Turkey
+ Affiliations - Affiliations

Corresponding Author

Ferah Armutcu, drferah@gmail.com

Received Date: August 22, 2024

Accepted Date: September 20, 2024

Abstract

It is obvious that obesity-related diseases are increasing in parallel with the prevalence of obesity, which has reached epidemic proportions worldwide. Cardiovascular disease, multiple cancers, stroke, type 2 diabetes and many other non-communicable diseases are more likely to develop in people living with obesity compared to those living at a healthy weight. In recent years, deeper investigation of the role of multi-organ interaction mechanisms in obesity and related chronic diseases has contributed to the development of new treatment and prevention strategies for obesity and its related-diseases. Bone tissue is also one of those target tissues in obesity. In this sense, the involvement of adipokines derived from adipose tissue in bone metabolism through hormonal and inflammatory factors suggests that obesity may be metabolically associated with bone loss. Moreover, recent epidemiologic and clinical studies have shown that obesity might be a risk factor for osteoporosis and fragility fractures. In obesity, various mechanisms affect bone remodeling and may be involved in the development of osteoporosis by triggering or modifying signaling pathways through the release of adipokines from adipose tissue and osteokines from bone. This review aims to elucidate the relationship between obesity and osteoporosis by focusing on the complex and reciprocal interaction between adipose tissue and bone tissue, discussing the changes in signaling pathways.

Keywords

Obesity, Adipokines, Signaling pathways, Osteokines, Bone remodelling, Osteoporosis

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