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Journal of Diabetes and Clinical Research

ISSN: 2689-2839

Research Article Open Access
Volume 6 | Issue 1 | DOI: https://doi.org/10.33696/diabetes.6.064

Effect of UV Photo Functionalization on the Antimicrobial Properties of Implants in Patients with Type 2 Diabetes Mellitus

Hakob Khachatryan1, Lazar Yessayan2, Gagik Hakobyan3,*
  • 1Maxillofacial Surgeon, Central Clinical Military hospital (Ministry of Defense of The Republic of Armenia), Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Yerevan State Medical University, Yerevan, Armenia
  • 2Professor, Head of Department of Therapeutic Stomatology, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  • 3Professor, Head of Department of Surgical Stomatology and Maxillofacial Surgery, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
+ Affiliations - Affiliations

Corresponding Author

Gagik Hakobyan, prom_hg@yahoo.com

Received Date: November 11, 2024

Accepted Date: December 19, 2024

Citation:

Khachatryan H, Yessayan L, Hakobyan G. Effect of UV Photo Functionalization on the Antimicrobial Properties of Implants in Patients with Type 2 Diabetes Mellitus. J Diabetes Clin Res. 2024;6(1):56-64.


Copyright: © 2024 Khachatryan H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The purpose of this study is to evaluate the effect of ultraviolet UV photo functionalization on the antimicrobial properties in implants installed in patients with type 2 diabetes mellitus.

The study included 74 patients with diabetes with unilateral/bilateral missing teeth (aged 36 to 63 years). The participants were randomly divided into 2 groups; Group-A included 38 patients with UV photo functionalized 204 implants and Group-B included 36 patients with non UV photo functionalized 183 implants. The clinical parameters of the dental implants were evaluated by assessing PD, BOP, MBL 6 months, 12 months, and 3 years after implant installation, compared with values at last follow-up. Concentrations of interleukin IL-1β and TNF-α cytokines in blood serum were evaluated using enzyme-linked immunosorbent assay.

After implant surgery, the patients in Group-A had minimal postoperative reactions including swelling, discoloration, discomfort, hematomas. After implant surgery, the patients in Group-B had a mild postoperative reaction including swelling and discomfort. Preoperative serum IL-1β levels and TNF-α in Group-A and Group-B patients did not differ significantly.

After implant surgery indicators of cytokines markers show correlation with Group-A and Group-B, the rates of IL-1β levels and TNF-α are higher in patients of Group-B. Analysis of the results showed the greatest increase in the rates of IL-1β levels and TNF-α in peri-mucositis and peri-implantitis.

The survival rate of implants in Group A patients is 97.3% and in Group B patients is 94.2% after five-years. The results of the study showed that monitoring levels of the cytokines TNF-α and IL-1β may aid in the early diagnosis of peri-implantitis and prognosis in high-risk patients with type 2 diabetes mellitus.

Keywords

Type 2 diabetes, Ultraviolet photo functionalization, Surface modification, Implants, Cytokines, IL-1β, TNF-α

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