Abstract
Background: Infertility, defined as the inability to conceive after at least 12 months of unprotected intercourse, affects up to 15.5% of couples of childbearing age. Assisted Reproductive Technology (ART) offers hope for successful pregnancy, though clinical pregnancy rates remain around 40%, with delivery success rates at 20%-30%. Despite numerous influencing factors, age, Antral Follicle Count (AFC), and Anti-Mullerian Hormone (AMH) serve as the current predictors of ART outcomes. However, these indicators lack comprehensive accuracy as they evaluate only specific stages of ART. Emerging research suggests a significant role for Vitamin D in reproductive physiology, yet its impact on the clinical pregnancy rates of in-vitro fertilization/intracytoplasmic sperm injection- embryo transfer (IVF/ICSI-ET) remains underexplored.
Purpose: This study analyzes various risk factors affecting clinical pregnancy rates in ART, emphasizing the role of Vitamin D levels in infertile women undergoing IVF/ICSI. We aim to correlate Vitamin D levels with ART-related factors and establish a predictive model for clinical pregnancy outcomes to guide personalized treatment plans and enhance ART success rates.
Keywords
Infertility, ART, Vitamin D, Factors affecting pregnancy, Logistic regression analysis