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Review Article Open Access
Volume 6 | Issue 2 | DOI: https://doi.org/10.33696/immunology.6.195

Advances of Immune Cells in the Pathogenesis and Targeted Therapy of Systemic Lupus Erythematosus

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China
  • 2Guangzhou Key Laboratory of Medical Nanomaterials, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China
  • 3Nanhai Translational Innovation Center of Precision Immunology, Sun Yat-Sen Memorial Hospital, Foshan, China
  • 4Cellular and Molecular Diagnostics Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China
  • 5Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China
  • 6Department of General Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China
  • #These authors contributed equally to this work
+ Affiliations - Affiliations

Corresponding Author

Phei Er Saw, caipeie@mail.sysu.edu.cn; Meng Zhang, zhangm7@mail.sysu.edu.cn

Received Date: April 22, 2024

Accepted Date: May 20, 2024

Abstract

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease reflecting an imbalance between regulatory and effector immune responses. With the rapid development of molecular biology and multi-omics, the pathogenesis of SLE has been gradually elucidated. In particular, imbalances and abnormalities in immune cell function have been shown to play an important role in the development of SLE. Understanding the specific pathogenesis of SLE is the basis for targeted therapy against specific targets. In this review, we describe the latest research progress on the involvement of immune cells in the pathogenesis of SLE and the potential of targeting different immune cells for therapeutic purposes. Then the importance of precision medicine for SLE disease management is also discussed. Finally, we emphasize recent advances in nanoparticle (NPs)-mediated drug delivery systems for targeted therapy of SLE.

Keywords

Systemic lupus erythematosus, Pathogenesis, Immune cells, Target therapy, Nanoparticles

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