Journal of Experimental Pathology

Review Article Open Access

Cancer Stem Cells, Together with Mesenchymal Stem Cells and Other Cooperative Cells, Govern the Initiation and Development of Cancer

Gabriella Racchetti , Jacopo Meldolesi

Until the end of last century, the origin and development of cancers were mostly attributed to the proliferation of their active cells, operative in collaboration with non-cancer cells of the patients. In particular, an important role was attributed to cells now recognized as mesenchymal stem cells (MSCs), first considered a few decades ago. Initially, however, the role attributed to these cells was only limited.

Mini Review Open Access

Varying Presentations of EBV-associated Clinical Entities with Emphasis on EBV-Associated T- and NK-cell Lymphoproliferative Disorders of Childhood

Jonathan Y. Keow , Nikhil A. Sangle

The Epstein-Barr Virus (EBV) is an endemic human herpesvirus, with 90% of people demonstrating serological evidence of prior exposure to EBV. In most cases, primary infections of EBV generate mild or asymptomatic clinical courses, but may present as infectious mononucleosis if contracted during young adulthood. In a small percentage of cases, Epstein- Barr virus infection may manifest as a noncanonical reaction, yielding a wide variety of clinical manifestations.

Research Article Open Access

Epidemiological Profile and Clinical Conditions of Women with or without Precursor Lesion for Cervical Cancer

Lyvia Mirelle Carneiro de França , Caroline Ramalho Galvão Assis , Lorena Ramalho Galvão , Maria Emília Cirqueira Silva , Bruna Matos Santos Dantas , Lorena Moura de Assis Sampaio , Magno Conceição das Mercês , Sarah dos Santos Conceição , Roberta Borges Silva , Julita Maria Freitas Coelho

Cervical cancer (CC) is a health condition faced by women, and affects mainly developed countries [1,2]. According to the world estimate of 570 thousand new cases, cervix cancer is on the fourth place of most frequent cases, representing 3.2% of all cancer types, and is also on the fourth place regarding mortality [1]. The 2018 estimate was 311,365 deaths worldwide. This corresponds to an estimated risk of 15.1 per thousand women [3,4].

Research Article Open Access

BNT162b2 mRNA COVID-19 Vaccine Elicited Antibody Responses in COVID-19-naïve Subjects

Chin Shern LAU , Soon Kieng Phua , Ya Li Liang , Mei Lin Helen Oh , Tar-Choon Aw

Coronavirus disease 19 (COVID-19) mRNA vaccines have gained international acceptance and have been proven to be safe and effective [1,2]. In a study of 3,950 frontline healthcare workers with no previous laboratory documentation of COVID-19 [3],

Research Article Open Access

Weight and Abdominal Adiposity Loss with Auricular Acupuncture – A Randomized Controlled Trial

Diogo Talaia de Matos¨ , Maria João Santos , António Moreira , Jorge Machado , Andreia Vieira

According to the WHO, obesity has more than doubled since 1980 [1]. The reality, however, is that most of the world’s population live in places where overweight and obesity kill more people than underweight. In 2016, more than a third of adults worldwide were classified as overweight or living with obesity, as were 41 million children younger than 5 years [2].

Research Article Open Access

Antifungal Effects of PC945, a Novel Inhaled Triazole, on Candida albicans Pulmonary Infection in Immunocompromised Mice

Yuki Nishimoto , Kazuhiro Ito , Genki Kimura , Kirstie A. Lucas , Leah Daly , Pete Strong , Yasuo Kizawa

Candida spp. are often detected from fungal cultures or mycobiome analysis of respiratory secretions, but are not usually treated since, even if detected persistently, the presence is assumed to be benign colonization unless invasive candidiasis in deeply immunocompromised subjects is suspected.