Journal of Diabetes and Clinical Research

Research Article Open Access

Elevated Opioid Growth Factor Alters the Limbus in Type 1 Diabetic Rats

Patricia J. McLaughlin , Joseph W. Sassani , David Diaz , Ian S. Zagon

Ocular surface complications occur in more than 50% of individuals diagnosed with diabetes. The financial and health-related burden of diabetes is increasing annually. Several major ocular complications associated with diabetes involve the limbus. The vascular limbus, adjacent to the avascular cornea, is the source of circulating growth factors, elevated glucose, and cytokines for the cornea.

J Diabetes Clin Res, 2023, Volume 5, Issue 1, p1-10 | DOI: 10.33696/diabetes.4.054

Commentary Open Access

A Commentary on “Better TIR, HbA1c, and Less Hypoglycemia in Closed-loop Insulin System in Patients with Type 1 Diabetes: A Meta-analysis”

Xiaojuan Jiao , Yunfeng Shen

Our team’s previous meta-analysis aimed to evaluate the efficacy and safety of closed-loop insulin system (CLS) in non-pregnant individuals with type 1 diabetes mellitus (T1DM). In this study, we aim to discuss the broader application of CLS in a more diverse population and address the current challenges and future development directions.

J Diabetes Clin Res, 2023, Volume 5, Issue 1, p11-14 | DOI: 10.33696/diabetes.4.055