Journal of Diabetes and Clinical Research

Original Research Open Access

Long-term Effects of Continuous Subcutaneous Insulin Infusion in Adults with Type 2 Diabetes Mellitus Patients: A Six-year Follow-up Retrospective Analysis

Soo-Bong Choi

The aim of this study was to evaluate the long-term effects of continuous subcutaneous insulin infusion (CSII) therapy on the improvement of metabolic control and beta-cell function in patients with type 2 diabetes mellitus. A single-center retrospective observational study was carried out in patients with T2DM who required CSII therapy due to suboptimal glycemic control. T2DM patients treated with the DANA-R Diabe care insulin pump (SOOIL Development Co., Ltd.) was followed for 6 years.

Original Research Open Access

Clinical Inertia in the Management of Patients with Uncontrolled Type 2 Diabetes: A Retrospective Cohort Study

Jubran Boulos , Eiman Amoor , Riad Taher

This study investigated clinical inertia in the management of type 2 diabetes mellitus (T2DM), a major challenge in clinical practice. The primary aim was to assess the delay in therapeutic intensification among patients with persistently elevated hemoglobin A1c (HbA1c) levels (>8.0%) who were already receiving two oral antidiabetic drugs, considering the availability of newer effective therapies. We conducted a retrospective cohort study using data from the Clalit Health Service database in Israel.

Case Report Open Access

Treatment Challenges in a Complex Presentation of Diabetic Ketoacidosis, Hyperosmolar Hyperglycemic Syndrome and Hypernatremia: A Case Report

Parth Dhamelia , Sara Mulville , Peyton Lester , Preston Skinner , Nicolas Tapia Stoll , Aleksandra Murawska Baptista , Abhinav Singla

Overlap between diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) is associated with significantly higher mortality than either condition alone. While hypertonic (trans locational) hyponatremia is common in hyperglycemic crises, clinically significant hypernatremia in mixed DKA/HHS presents with certain treatment challenges due to rapid osmotic shifts during insulin therapy. A 40-year-old woman with non-significant past medical history presented with vomiting, polyuria, polydipsia, and confusion for two days.

Commentary Open Access

Health Care Systems and Policy: Role of Leadership in the Obesity Crisis

Ayanda C. Mkhize , Michael Anaafi , Nehemiah Nashas , Akram Lusanda , Jessica L. Jones

Sato’s article “Decline in Physical Activity after Age 35 Increases the Risk of Obesity, Insulin Resistance, and Diabetes” highlights the obesity and diabetes crises, offering strategies to mitigate these illnesses through health promotion programs and personal motivation. To promote population behavior change, approaches that include societal, structural and personal influences are imperative.

Original Research Open Access

Real-World Impact of an Immersive Continuing Education Initiative on Screening for Type 1 Diabetes

Jay H Shubrook , Lauren Welch , Nicole Longo , Shpetim Karandrea , Tom Bretgartner

Screening for type 1 diabetes (T1D) can be challenging, causing diagnostic delay and potentially serious health consequences. Continuing education (CE) in T1D is lagging but could help improve clinician knowledge of and engagement in T1D screening behaviors. his retrospective, case-control study assessed pre-/post-changes in clinician knowledge of T1D screening and management (N=4817) following exposure to an interactive, multicomponent CE program (DETECT T1D) from May 2024 to January 2025.