Journal of Diabetes and Clinical Research

Research Article Open Access

Ephrin B1 Regulates Inflammatory Pathways in Retinal Müller Cells

Li Liu , Youde Jiang , Mohamed Al-Shabrawey , Jena J. Steinle

The role of inflammation has been accepted as a factor in the complications of diabetic retinopathy. Discovery of the upstream regulation of these inflammatory factors has remained a challenge. In this study, we explored the actions of ephrin B1 in retinal Müller cells and their actions on inflammatory proteins. We used diabetic human and mouse samples, as well as Müller cells in culture to measure ephrin B1 in Müller cells.

Clinical Case Study Open Access

A Clinical Case Report: Utility of Amniotic Membrane in Treating a Geriatric Diabetic Patient with a Chronic Pressure Ulcer

Alison L. Ingraldi , Kristina Galbreath , Denise Jones , Darlene Lee , Aaron J. Tabor

Chronic wound closure is the inability for a wound to progress through the standard wound healing stages and timeframe, often stalling during the inflammatory stage. This paper presents a two-year open wound endured by a Native American patient of geriatric age and uncontrolled type II diabetes based on elevated A1c levels. Multiple therapeutic modalities had been attempted to close the wound, without improvement. 

Mini Review Open Access

Use of Sodium-Glucose Co-transporter-2 Inhibitors after Acute Myocardial Infarction

Nasser Mikhail

Whether sodium-glucose co-transporters-2 (SGLT2) inhibitors have beneficial effects on cardiovascular (CV) events and mortality if given within few days from acute myocardial infarction (AMI) is unknown. The DAPA-MI trial (n= 4,107) is the only available study designed to evaluate the impact of administration of dapagliflozin on CV outcomes and mortality if started within 10 days from occurrence of an AMI.

Mini Review Open Access

Semaglutide for Treatment of Obesity-Related Heart Failure with Preserved Ejection Fraction in Patients with and without Diabetes

Nasser Mikhail , Soma Wali

The glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide is effective for the treatment of obesity and type 2 diabetes mellitus (T2DM). The purpose of this article is to define the therapeutic role of semaglutide for obesity-related heart failure with preserved ejection fraction (HF-pEF). Methods: Critical review of 2 recent randomized trials, the Subjects with Obesity-related Heart Failure with Preserved Ejection Fraction (STEP-HFpEF) and STEP-HFpEF DM.

Research Article Open Access

Lifestyle Modification Practice and Associated Factors among Type 2 Diabetic Patients in Oromia: A Multicenter Study

Dursa Hussein , Tinsae Abeya Geleta , Amanuel Girma , Tadesse Bekele , Derara Girma , Seifu Mohammed Ibrahim , Meron Seyoum Lakew , Bedo Megersa Kumbe , Befekadu Tesfaye Oyato

Diabetes mellitus is a metabolic disorder characterized by high blood glucose levels due to insulin irregularities. It is frequently accompanied by difficulties in the metabolism of carbohydrates, fats, and proteins. Despite the significant loss of life and resources associated with DM, management remains insufficient. This management typically involves pharmacologic interventions and lifestyle modifications (LSM). However, a majority of patients and caregivers tend to disregard LSM in the management of type 2 diabetic patients.

Research Article Open Access

Epac1 Regulates Ephb1/Ephrin B1 in Retinal Müller Cells

Li Liu , Youde Jiang , Jena J. Steinle

Eph B1/Ephrin B1 signaling has been shown to play a role in inflammation and pain in some targets; however, its upstream regulation is less clear. To investigate whether exchange protein for cAMP1 (Epac1) can regulate EphB1/ephrin B1 in retinal Müller cells, we generated Epac1-Müller cell specific knockout mice. We used protein analyses to show that Epac1 regulates both EphB1/ephrin B1, as well as high mobility group box 1 (HMGB1) and NLR family pyrin domain containing 3 (NLRP3).

Research Article Open Access

Comorbidity of Hyperglycemia and Dyslipidemia among Factory Workers: A Study on the Interrelationship of Metabolic Disorders in Occupational Settings

Benjamin Tetteh Mensah , Dorinda Naa Okailey Armah , Jemima Okyere , Lawrence Annison , Samuel Antwi-Baffour

Hyperglycemia, characterized by elevated blood glucose levels, often leads to diabetes mellitus and severe complications if unmanaged. Globally, hyperglycemia is a pressing public health issue, exacerbated by increasing diabetes prevalence. In sub-Saharan Africa, including Ghana, the rise in diabetes cases is alarming, necessitating urgent health interventions. Concurrently, dyslipidemia, marked by abnormal lipid levels, contributes significantly to cardiovascular diseases. This study aims to investigate the comorbidity of hyperglycemia and dyslipidemia among factory workers in an urban center in Ghana, providing insights into this high-risk group's health status.