Commentary - Journal of Experimental Neurology (2020) Volume 1, Issue 4
Integrating Neurology and Psychiatry throughout Educational Curricula for Healthcare Professionals
Brinda Desai Bradaric1,4, Alana Kirby2,4, T. Celeste Napier3,4*
1Department of Health Sciences, Rush University Medical Center, Chicago, IL 60612, USA
2Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
3Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
4Center for Compulsive Behavior and Addiction, Rush University Medical Center, Chicago, IL 60612, USA
- *Corresponding Author:
- T. Celeste Napier
Received date: November 12, 2020; Accepted date: December 14, 2020
Citation: Bradaric BD, Kirby A, Napier TC. Integrating Neurology and Psychiatry throughout Educational Curricula for Healthcare
Professionals. J Exp Neurol. 2020;1(4): 168-172.
Copyright: © 2020 Bradaric BD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Impulse control disorder, Neurology education, Psychiatry education, Interdisciplinary communication, Medical curriculum
We recently reviewed the scientific literature linking dopamine agonist pharmacotherapy for neurological disorders to the development of impulsive and compulsive spectrum disorders (ICSDs) . This link was not clinically recognized until thousands of treated patients suffered from devastating emotional, financial and social difficulties associated with the co-occurring addictions. Here, we expand on this scientific overview to comment on how the clinical scenario emerged, and educational solutions to avoid similar consequences in the future. In brief, we hold that bridging the brain-centric disciplines (e.g., neurology and psychiatry) within medical education curricula and training is key. Teaching of these disciplines to future health professionals needs to emphasize integrated learning and practice to improve patient care.
Medical education and training on diagnosis of brain dysfunction and pharmacological interventions tends to be separated by field of study. For example, the pathophysiology, symptomology and treatment of Parkinson’s disease (PD) are taught in neuroscience courses. Such diseases are diagnosed by neurologists using motor symptoms. Psychosocial behavioral disorders and treatment are taught in psychology and psychiatry courses and are characterized by descriptions of behavior and mental status. This separation reflects the historical tendency for neurologists and psychiatrists to view brain dysfunction differently [2,3]. PD is a brain disease
associated with pathology or anatomical changes in neurotransmitter substrates of particular brain regions
(e.g., lesions in the dopaminergic neurons of the basal
ganglia). By contrast, psychiatrists refer to mental health
disorders as functional dysregulation of diffuse brain
systems. Neurologists and psychiatrists have differing
clinical philosophies to treating diseases, and the medical
language used to describe brain dysfunction also differs
in the two fields. For example, neurologists describe
dysfunction by emphasizing the specific substrate damage
or pathology (e.g., dopamine dysregulation syndrome),
whereas psychiatrists emphasize mental function within
the overall brain (e.g., substance use disorder). Though
it may seem practical to separate diseases that afflict the
brain and mind, these traditions and philosophies do not
emphasize the substantial overlap between traditional
neurologic and psychiatric manifestations. The separation
also has implications for treating clinicians, as comorbid
disorders are often mismanaged, under recognized and
under treated [4-6]. Symptoms and treatment side effects
that lie at the intersection of neurology and psychiatry may
be missed or neglected by either discipline individually .
Development of ICSDs in PD patients following dopamine agonist therapy is an excellent example of a condition that exists at the intersection of neurology and psychiatry. The basic science and clinical evidence that link ICSDs in PD is detailed in Napier et al., 2020  and includes: (i) onset of ICSDs is related to initiation of, or the increase in dose for, dopamine agonist therapy, and (ii) reducing the dose of the dopaminergic agonist or terminating treatment reduces or terminates ICSDs. In 2010, a large cross-sectional study of 3,090 idiopathic parkinsonian patients in the USA and Canada reported a high prevalence of ICSD during dopamine agonist therapy . This landmark study was a
collaboration among psychiatrics and neurologists, and its
publication is highly recognized as a pivot point in raising
clinical awareness of the ICSD risks of dopamine agonist
therapy [8-15]. We consider that clinical awareness should
have long-preceded 2010, as the function of dopamine
agonists and their cognate receptors have been known for
decades. To make this point, a brief overview of dopamine
pharmacology is provided.
Dopamine agonists have high affinity for, and are efficacious at, dopamine receptors. Apomorphine was first recognized as a dopamine agonist in the 1960s. As PD was known to reflect deficits in brain dopamine transmission in brain regions that govern motor function, apomorphine was clinically explored as a PD therapeutic. However, clinical use was limited by side effects and the utility of the dopamine precursor, levodopa (L-DOPA) in conjunction with peripherally acting carboxylase inhibitor (e.g. carbidopa) became appreciated. L-DOPA/ carbidopa provides excellent relief of motor symptoms of PD, but the side effect profile includes problematic fluctuations in motor benefits, and with chronic use, many patients develop troublesome dyskinesias. Ergot-alkaloid dopamine agonists, such as bromocriptine, pergolide and cabergoline, were developed to combat the side effects and complications associated with chronic levodopa therapy [16,17]. The use of these drugs was expanded to early PD, driven in part by the desire to spare patients the adverse effects of L-DOPA. However, the ergot-derived agonists have a high risk of cardiac valvular, pulmonary and peritoneal fibrosis . During the 1990’s non-ergot alkaloids, e.g., pramipexole and ropinirole, were developed to selectively target particular subtypes of dopamine receptors and avoid the side effect profiles seen with receptor non-selective ergot-alkaloid dopamine agonists. In 1997, pramipexole and ropinirole were approved for clinical use in the United States and there was a rapid increase in their clinical use.
Dopamine receptors are classified based on genetic and protein homology, and effects on signaling cascades. There are two major classes (or families), D1 and D2. The D1 family includes subtypes, referred to as D1 and D5. The D2 family includes D2, D3, and D4 subtypes. Pramipexole and ropinirole have particularly high affinity for the D2 and D3 subtypes. By contrast, the older agonists are less selective, activating receptors in both D1 and D2 families. The D2/ D3 receptor preference affords a clinical profile wherein motor benefits are obtained, while avoiding the side effects often seen with dopamine agonists that activate both receptor families. However, D2/D3 receptors are not only localized to brain regions that regulate motor function, e.g., the basal ganglia, but are highly expressed through out limbic brain regions. It has long been known that limbic regions govern emotion-laden, reward-motivated behaviors. These regions remain largely intact in PD, and thus, D2/D3 receptor-preferring agonists ‘over activate’ the limbic system which can lead to ICSDs (overviewed in Napier et al., 2020) .
ICSDs that occur during dopamine agonist therapy can cause significant harm to patients. Behaviors such as gambling, drug abuse, and sexual promiscuity have destroyed the finances and relationships of patients on dopamine agonists [18,19]. Healthcare outcomes often are significantly worsened, including patient experience, effectiveness of care, increased time of care and management, and increased number of readmissions or office visits. The psychosocial behavioral side effects occur more frequently with dopamine agonists compared to other available treatments for PD . Thus, earlier recognition of ICSDs during agonist therapy could have changed clinical practice and prevented patient harm.
To ensure that brain diseases and disorders that intersect neurology and psychiatry are recognized, managed and treated, students need to be trained to think of brain pathology and dysfunction in an integrated fashion. Our current educational system offers limited interaction between neurology and psychiatry. Currently, undergraduate education and training produce expert clinicians in their chosen discipline, but this model contributes to the persistence of specialty silos and limited crosstalk between fields. Identifying and addressing the link between dopamine agonists and ICSDs, for example, requires clinicians to connect neurobiological substrates, pharmacological effects, and psychiatric symptoms. Recognizing biologically plausible neuropsychiatric side effects requires integrating knowledge from the separate contexts of neurology and psychiatry. Ideally, these gaps in knowledge could be addressed with changes to the curriculum allowing topics to be introduced and taught in combination. Such training would enhance teamwork among clinicians, which is particularly important in complex neurological and psychiatric conditions, and patients would receive holistic treatment, which can improve health care outcomes [4-6,20-25].
There are many opportunities for interdisciplinary education on the brain in health profession curricula. For integration to be most impactful, it should be introduced during bachelor’s education, reinforced during medical education, and mastered during residency training. Bachelor’s degree course work lays the groundwork for the understanding of the human nervous system and behavior. However, many students who aspire to advanced healthcare practice degrees earn a bachelor’s degree without exposure to psychology, neuroscience or either field. According to the American Association of Medical Colleges, of the 21,869 students that matriculated into medical school in 2019, 57% majored in biological sciences and 1% in social sciences . Students in these
majors may be exposed to psychology and neuroscience as
part of their curriculum. However, this is not a guarantee
as biology majors at a 4-year university are not generally
required to take psychology as a part of the major core
requirements. Furthermore, the 42% of matriculants with
alternate majors  likely have no requirement to take
classes either in psychology or the neurosciences. The
lack of basic background in neuroscience and psychology
in the current educational system is the first stumbling
block in training clinicians who are able to recognize the
neurobiological substrates involved in disorders that lie
at the intersection of neurology and psychiatry, such as
ICSDs during dopamine agonist therapy for PD.
The four years of bachelor’s study can be leveraged with courses that allow students to make connections between the fields of neurology and psychiatry. Bachelor level education can include neuropsychology courses as an elective for future health care professionals. This requirement could be independent of the student’s major to increase awareness and learning of foundational concepts of complex brain disorders. An introductory course can provide the foundations of normal brain function and anatomy and its relation to behavior. Advanced courses in neuropsychology can focus on changes of structure and function in relation to changes to behavior, with theoretical and practical applications. Well-established neuroscience and psychology courses could incorporate lectures, case studies, or workshops that showcase the relationship between brain systems and behavior. By intentionally teaching the two subjects together, students can start to make the connections between brain function and behavior. These foundational courses can teach the student how to learn and integrate fundamental concepts in neurology and psychiatry.
To reinforce the fundamental concepts learned during bachelor’s education, medical education in professional schools must continue integrating neurology and psychiatry within the curriculum. Currently, in the United States, physicians complete four years of undergraduate medical education. During this education, medical students are largely exposed to psychological concepts separately from neurological concepts, and treatment of the mind separately from treatment of the body. This leaves newly minted clinicians ill prepared to appreciate connections between these two fields. To facilitate bridging concepts of neurology and psychiatry, the coursework in the first two years of medical undergraduate education can integrate normal and abnormal function of neurobiological substrates and pathways when discussing disease, mental function and clinical behavior. The relationship between neurology and psychiatry can be further developed as students learn about medications used to treat neurological and psychiatric diseases. This allows students to ascertain the similarities and differences between treatments and conceptualize potential neurological and psychiatric side effects that can be associated with therapy. Further, case studies that are used to provide a practical clinical application of the learning materials can include examples of disease and/or side effects from medications that intersect neurology and psychiatry. Integration of neurology and psychiatry allows for common concepts to be combined, which offsets the apparent increase in coursework by reducing repetition and facilitating learning of advanced and complex concepts. These changes to curriculum during the first years of medical school can help students master the connections between brain function and behavior. The last years of medical school can reinforce interdisciplinary learning by allowing those students who have chosen neurology or psychiatry as their track, to have rotations in child neurology and psychiatry, as well as electives in subspecialties such as neuroradiology, neuropathology, and geriatrics .
These rotations can foster interaction between neurology
and psychiatry, reinforce the connection between brain
function and behavior, and strengthen the concept of
interdisciplinary collaboration for students.
For clinicians to master neurological and psychiatric concepts and apply them to their practice, exposure to both fields must continue during residency training and fellowship. Currently, an overwhelming majority of physicians in the United States complete one residency track, such as internal medicine, psychiatry or neurology. Out of 4 years of training, residents in psychiatry are required to spend up to 2 months on a clinical neurology rotation, and neurology residents spend up to 1 month on a psychiatry service. Though several medical institutions across the United States have combined neurologypsychiatry residency programs, the length of these programs can be unattractive. To address this need, medical centers can create dual residency programs that are limited to 4-5 years or limit rotations in one specific area. Having residents and fellows rotate through clinics, such as memory disorder clinics, epilepsy centers and geriatric clinics that may have patients that exhibit both neurological and psychiatric symptoms, are great experiences that allow trainees to work closely with members of both specialties. It can also allow a reduction in the number of rotations within either discipline. These rotations would provide a holistic experience with intentional cross-disciplinary training.
Integration of neurology and psychiatry that occurs throughout education (bachelor’s, medical) and training will lead to clinicians developing an expertise in brain diseases and behavior, as well as improved awareness and management. Repetition is the key to learning and improved practice. Further, repetition of integrated learning and team-based practice can take multiple forms, such as case studies, presentations/seminars, and grand rounds. The more often students are taught and trained in an integrated learning environment where they are forced to make connections and apply information to different fields, the more likely they will be to recognize diseases that intersect neurology and psychiatry. The more often students are placed in an environment that allows for collaboration, the more likely they will be to see the value of teamwork.
Though challenging, integrating neurology and psychiatry would be beneficial. Both neurology and psychiatry have robust and rigorous curricula, and any integration of the two fields will require careful consideration to maintain equity between them. Potential problems including duration of training and curricular scope will need to be taken into careful consideration. These challenges can be overcome and the outcome rewarding. An integrated education and training can produce clinicians with a better understanding of brain diseases/disorders and treatment, so they are better prepared to diagnose difficult and complex diseases that have clinical features of both neurology and psychiatry. Moreover, clinicians will be aware of side effects associated with pharmacological intervention and be able to critically evaluate diseases and medications that straddle neurology and psychiatry, such as the risk of developing ICSDs with dopamine agonists that we have highlighted in this commentary. Clinicians will be able to better counsel patients and caregivers about potential side effects associated with medications and clinical symptoms that may emerge due to diseases and/ or disease progression. The complementary nature of neurology and psychiatry can help advance our knowledge of brain disease by provide biological basis for psychiatric disorders and more nuanced behavioral analysis for neurological disorders. Finally, integration within the educational and training system may potentially reduce the stigma associated with psychiatric illness. Ultimately, we believe that implementing these changes will improve individualized patient care and healthcare outcomes.
Conflicts of Interest
The authors have no relevant disclosures or conflicts of
interest to declare.
Alana Kirby, MD PhD received support from the Parkinson’s Foundation Institutional Movement Disorders Fellowship Award to Rush University Medical Center, grant number PFMDS-1813. T. Celeste Napier, PhD received funding from the United Stated Public Health Service, Grants NS074014, NS087559, DA047901 and ES025920.
- Napier TC, Kirby A, Persons AL. The role of
dopamine pharmacotherapy and addiction-like
behaviors in Parkinson’s disease. Progress in Neuro-
Psychopharmacology and Biological Psychiatry. 2020 Aug
- Ibáñez A, García AM, Esteves S, Yoris A, Muñoz E,
Reynaldo Let al. Social neuroscience: undoing the schism
between neurology and psychiatry. Social Neuroscience.
2018 Jan 2;13(1):1-39.
- Berrios GE. Historical epistemology of the bodymind
interaction in psychiatry. Dialogues in Clinical
Neuroscience. 2018 Mar;20(1):5.
- Kanner AM. When did neurologists and psychiatrists
stop talking to each other?. Epilepsy & Behavior. 2003 Dec
- Fitzgerald M. Do psychiatry and neurology need a
close partnership or a merger?. BJPsych bulletin. 2015
- White PD, Rickards H, Zeman AZ. Time to end the
distinction between mental and neurological illnesses.
Bmj. 2012 May 24;344:e3454.
- Weintraub D, Koester J, Potenza MN, Siderowf
AD, Stacy M, Voon V, et al. Impulse control disorders
in Parkinson disease: a cross-sectional study of 3090
patients. Archives of Neurology. 2010 May 1;67(5):589-95.
- Ávila A, Cardona X, Martín-Baranera M, Bello J, Sastre
F. Impulsive and compulsive behaviors in Parkinson’s
disease: a one-year follow-up study. Journal of the
Neurological Sciences. 2011 Nov 15;310(1-2):197-201.
- Borovac JA. Focus: The Aging Brain: Side effects of a
dopamine agonist therapy for Parkinson’s disease: a minireview
of clinical pharmacology. Yale J Biol Med . 2016
- El Otmani H, Mouni FZ, Abdulhakeem Z, Attar Z,
Rashad L, Saali I, et al. Impulse control disorders in
Parkinson disease: A cross-sectional study in Morocco.
Revue Neurologique. 2019 Apr 1;175(4):233-237.
- Garcia-Ruiz PJ, Castrillo JC, Alonso-Canovas A,
Barcenas AH, Vela L, Alonso PS, et al. Impulse control
disorder in patients with Parkinson’s disease under
dopamine agonist therapy: a multicentre study. Journal
of Neurology, Neurosurgery & Psychiatry. 2014 Aug
- Hassan A, Bower JH, Kumar N, Matsumoto JY, Fealey RD, Josephs KA, et al. Dopamine agonist-triggered pathological behaviors: surveillance in the PD clinic reveals high frequencies. Parkinsonism & Related Disorders. 2011 May 1;17(4):260-4.
- Perez-Lloret S, Rey MV, Fabre N, Ory F, Spampinato U, Brefel-Courbon C, et al. Prevalence and pharmacological factors associated with impulse-control disorder symptoms in patients with Parkinson disease. Clinical Neuropharmacology. 2012 Nov 1;35(6):261-5.
- Gómez CC, Dueñas MS, Bernal O, Araoz N, Farret MS, Aldinio V, Montilla V, Micheli F. A multicenter comparative study of impulse control disorder in Latin American patients with Parkinson disease. Clinical Neuropharmacology. 2017 Mar 1;40(2):51-5.
- Voon V, Sohr M, Lang AE, Potenza MN, Siderowf AD, Whetteckey J, et al. Impulse control disorders in Parkinson disease: a multicenter case–control study. Annals of Neurology. 2011 Jun;69(6):986-96.
- Horowski R. A history of dopamine agonists. From the physiology and pharmacology of dopamine to therapies for prolactinomas and Parkinson’s disease–a subjective view. Journal of Neural Transmission. 2007 Jan 1;114(1):127-34.
- Tolosa E, Martí MJ, Valldeoriola F, Molinuevo JL. History of levodopa and dopamine agonists in Parkinson’s disease treatment. Neurology. 1998 Jun 1;50(6 Suppl 6):S2-10.
- Nicholas Kaster JD. Appellate court affirms dismissal of Mirapex® products liability suit as time-barred. Products Liability Law Daily. 2019.
- Weintraub D. Impulse control disorders in Parkinson’s disease: a 20-year odyssey. Movement Disorders. 2019
- Vaslamatzis G. Framework for a new dialogue between
psychoanalysis and neurosciences: is the combined neuropsychoanalytic
approach the missing link?. Philosophy,
Ethics, and Humanities in Medicine. 2007 Dec;2(1):1-4.
- Perez DL, Keshavan MS, Scharf JM, Boes AD, Price
BH. Bridging the great divide: what can neurology learn
from psychiatry?. The Journal of Neuropsychiatry and
Clinical Neurosciences. 2018 Oct;30(4):271-8.
- Reilly TJ. The neurology-psychiatry divide: a thought
experiment. BJPsych bulletin. 2015 Jun;39(3):134-5.
- Telles-Correia D. The mind-brain gap and the
neuroscience-psychiatry gap. Journal of Evaluation in
Clinical Practice. 2018 Aug;24(4):797-802.
- Price BH, Adams RD, Coyle JT. Neurology and
psychiatry: closing the great divide. Neurology. 2000 Jan
- Azuar C, Levy R. Behavioral disorders: the ‘blind
spot’of neurology and psychiatry. Revue Neurologique.
2018 Apr 1;174(4):182-9.
- AAMC. MCAT and GPAs for Applicants and
Matriculants to U.S. Medical Schools by Primary
Undergraduate Major, 2020-2021. In: MCAT and GPAs
for Applicants and Matriculants to U.S. Medical Schools
by Primary Undergraduate Major -, editor. AAMC2020.
- Keshavan MS, Price BH, Martin JB. The Convergence
of Neurology and Psychiatry: The Importance of Cross-
Disciplinary Education. JAMA. 2020 Aug 11;324(6):554-