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Editorial Open Access

Vitamin B12 Deficiency: Current Therapeutic Approaches and Emerging Strategies

  • 1Service de Médecine Interne, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
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Corresponding Author

Emmanuel Andres, emmanuel.andres@chru-strasbourg.fr

Received Date: October 29, 2025

Accepted Date: October 30, 2025

Abstract

Vitamin B12 (cobalamin) is an essential micronutrient involved in DNA synthesis, erythropoiesis, and neurological function. Deficiency can result in hematological, neurological, and psychiatric manifestations, potentially leading to severe and irreversible complications if untreated. This editorial reviews current therapeutic strategies for vitamin B12 deficiency, including conventional supplementation forms, recommended dosages, and treatment durations. Additionally, emerging administration routes—sublingual, intranasal, transdermal, intradermal, and gastrostomy—are explored for their potential to enhance patient compliance and therapeutic efficacy. Special considerations in high-risk populations, including the elderly, pregnant women, and patients with gastrointestinal disorders, are also discussed. Optimizing therapeutic strategies for B12 deficiency is critical for improving patient outcomes and quality of life.

Keywords

Vitamin B12, Cobalamin, Cyanocobalamin, Anemia

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