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Archives of Medical Case Reports

ISSN: 2691-7971

Case Series Open Access
Volume 5 | Issue 1 | DOI: https://doi.org/10.33696/casereports.4.024

Two Cases of Burkitt Lymphoma Presenting as Solid Ovarian Masses

Blessing N. Ngam1,*, James A. Brown2, Lorraine Elit3, Richard L Bardin4, Mark J. Snell5
  • 1Medical Doctor and Surgical Resident of the Pan African Academy of Christian Surgeons (PAACS) -Mbingo Baptist Hospital – Baptist Institute of Health Sciences, Cameroon
  • 2Emeristus Program Director for the Pan African Academy of Christian Surgeons (PAACS) at the Mbingo Baptist Hospital – Baptist Institute of Health Sciences, Cameroon
  • 3Vice Dean for Research at the Baptist Institute of Health Sciences, Professor emeritus in the Department of Obstetrics and Gynecology at McMaster University and, faculty in the PanAfrican Academy of Christian Surgeons (PAACS) and Associate Professor in the Global Health division of the Dept of Ob-Gyn at Loma Linda University, USA
  • 4Associate Professor of Medicine at the Loma Linda University, USA, Pathologist for the Mbingo Baptist Hospital and Faculty of Medicine at the Baptist Institute of Health Sciences Christian Internal Medicine Specialization Program and board certified Anatomic & Clinical Pathologist
  • 5Associate Professor of Surgery at the Loma Linda University, USA ,and Program Director of Pan African Academy of Christian Surgeons (PAACS) -Mbingo Baptist Hospital – Baptist Institute of Health Sciences, Cameroon
+ Affiliations - Affiliations

Corresponding Author

Ngam Blessing Ngoin, ngamngoin@yahoo.com

Received Date: April 15, 2023

Accepted Date: April 26, 2023

Citation:

Ngam BN, Brown JA, Elit L, Bardin RL, Snell MJ. Two Cases of Burkitt Lymphoma Presenting as Solid Ovarian Masses. Arch Med Case Rep. 2023;5(1):24-29.


Copyright: © 2023 Ngam BN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Endemic Burkitt lymphoma has been associated with the Epstein Barr Virus (EBV), particularly in malaria-endemic regions. Primary ovarian Burkitt is an infrequent entity of this disease, and its diagnosis still poses a challenge.

Summary: We present two cases. The first case is that of a 23-year-old female G1P1 who presented with a two-week history of abdominal pain and progressive distension. Her examination was remarkable for two pelvic masses and signs of ascites. An ultrasound scan showed bilateral solid adnexal masses, ascites, and mild splenomegaly. Tumor markers for ovarian and germ cell tumors were within the normal ranges. Cytology on ascitic fluid was negative for malignancy. Lactate dehydrogenase (LDH) level and further imaging were not done due to financial constraints. With the working diagnosis of an ovarian epithelial malignancy versus drop metastases, she underwent exploratory laparotomy, total abdominal hysterectomy, bilateral salpingo-oophorectomy, appendectomy, omentectomy, and debulking of peritoneal implants. Histopathology two weeks after surgery showed Burkitt lymphoma. The second case is that of a 12-year old female whose management averted surgery, following the recommendations made from our first case.

Conclusion: Lymphomas are amongst the most common tumors in the pediatric age group. Clinicians should maintain a high index of suspicion in the face of fast-growing tumors. Burkitt lymphomas respond well to chemotherapy, and surgery is seldom necessary except for life-threatening presentations. Management of oncologic cases that are not straightforward should follow a multidisciplinary approach.

Keywords

Ovary, Burkitt lymphoma, Diagnosis

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Two Cases of Burkitt Lymphoma Presenting as Solid Ovarian Masses

Endemic Burkitt lymphoma has been associated with the Epstein Barr Virus (EBV), particularly in malaria-endemic regions. Primary ovarian Burkitt is an infrequent entity of this disease, and its diagnosis still poses a challenge.

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