Volume 4 | Issue 3 | DOI: https://doi.org/10.33696/Signaling.4.097
The Finer Points of Podocyte Sphingolipid Metabolism in Diabetic Kidney Disease
- 1Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA
- 2Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, Miami, Florida, USA
Alla Mitrofanova, firstname.lastname@example.org
Received Date: June 05, 2023
Accepted Date: July 06, 2023
Mitrofanova A, Njeim R, Fornoni A. The Finer Points of Podocyte Sphingolipid Metabolism in Diabetic Kidney Disease. J Cell Signal. 2023;4(3):99-103.
Copyright: © 2023 Mitrofanova A et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
C1P, Ceramdie, DKD, Podocyte, S1P, Sphingolipid
Being a sophisticated and highly organized living system, mammals harbor a large number of biomolecular machineries which represent a dynamic and complex network of interconnections responsible for the effective operation, development and survivability of their body cells. Sphingolipids are a special class of lipids in eukaryotic cells, which have recently gained the attention of researchers because of their involvement in several fundamental processes of living cells, including proliferation
S1P Generation by Sphingosine Kinase-2 in Recruited Macrophages Resolves Lung Inflammation by Blocking STING Signaling in Alveolar Macrophages
Acute respiratory distress syndrome (ARDS) is the major cause of mortality among hospitalized acute lung injury (ALI) patients. Lung macrophages play an important role in maintaining the tissue-fluid homeostasis following injury. We recently showed that circulating monocytes recruited into the alveolar space suppressed the stimulator of type 1 interferon genes (STING) signaling in alveolar macrophages through sphingosine-1-phosphate (S1P).
Diabetic kidney disease (DKD) is a common complication of diabetes, characterized by kidney damage. Podocytes are specialized, terminally differentiated cells in the kidney’s filtration barrier that are key responders to the metabolic and environmental changes that occur in diabetes. Change in the function and in the number of podocytes is the main signature of the development and progression of DKD.