Epithelial-Mesenchymal Transition (EMT) and its reverse process, Mesenchymal-to-Epithelial Transition (MET) are well-studied processes involved in cell differentiation during development and organ formation, as well as in its reverse process in somatic cell reprogramming. In addition, involvement of a deregulated form of the EMT in tumor progression has long been known. Understanding the molecular and cellular mechanisms for cancer development, progression, and metastasis is a fundamental challenge toward advancing and improving therapeutic strategies.

Idiopathic pulmonary fibrosis (IPF) is an incurable disease that affects approximately 3 million people worldwide. Although two drugs (nintedanib and pirfenidone) have been approved for treatment of IPF, currently there is a lack of effective pharmacotherapy that could stop the progression or offer a cure for this devasting disease.

Mitochondrial permeability transition pore (PTP) plays an important role in mitochondrial physiology and cell fate. Emerging studies highlight PTP forms from F-ATP synthase, but whether F-ATP synthase inhibitory factor 1 (IF1) regulates the activity of PTP is basically unknown. We have recently demonstrated that IF1 interacts with p53-CyPD complex and promotes opening of the PTP, and IF1 is necessary for the formation of p53-CyPD complex.

Metastasis is the perilous aspect of cancer and is responsible for 90% of deaths due to cancer. It represents an enigmatic and complex biological cascade that is poorly understood. The constant development in cancer research and the advent of new principles in metastasis have discovered some of the molecular keystones like epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) of this cascade.

This commentary deals with our publication from 12.2024, entitled “Early Detection and Treatment Options for Psychosis in Transition from Childhood to Adolescence: A Review About Three Decades of Psychiatric Clinical Experience”. The article delves into the complex relationship between substance abuse and psychosis, focusing on the critical role of early detection, family involvement, and continuous monitoring in managing psychosis, particularly during the transition from childhood to adolescence.