Commentary Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.33696/immunology.3.075
Prospects of JAK Inhibition in the Framework of Bone Loss
Susanne Adam1,2, Georg Schett1,2, Silke Frey1,2,*
- 1Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
- 2Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany
Corresponding Author
Silke Frey, Silke.Frey@uk-erlangen.de
Received Date: November 12, 2020
Accepted Date: January 21, 2021
Adam S, Schett G, Frey S. Prospects of JAK Inhibition in the Framework of Bone Loss. J Cell Immunol. 2021; 3(1): 36-41. J
Copyright: © 2021 Adam S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords
JAKinibs, Bone, Osteoimmunology, Rheumatoid arthritis, Oosteoporosis
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Cytokine receptors may possess an intrinsic capability for the transduction of signals upon engagement by the respective cytokine ligand [1]. However, if they lack an own intracellular signaling entity, they rely on other signaling machineries. One of the key intracellular signaling molecules mediating cytokine effects on immune cells are Janus kinases (JAKs),