However, the entire coagulation cascade is dysfunctional, in progressed chronic diabetes and cancer patients.

Platelets are small anuclear cells shed from the megakaryocyte, at a rate of ~10¹¹/day [1], maintaining a blood concentration of 100-450 x 10⁹/L in healthy adults. As the second most abundant circulating cells, they are becoming increasingly recognized for their versatility and cross-talks in cancer, development, immunology among others.

Revacept, a dimeric fusion protein of the extracellular domain of GPVI and the human Fc-fragment, inhibits collagen-mediated platelet adhesion and subsequent aggregation at the site of vascular injury. Finally, the possible utility of this pharmacological approach in the prevention of tumor metastasis is discussed.

Platelet preparations (PDPs) have gained success, mainly due to their high concentrations of biologically active molecules, such as growth factors and cytokines, which play an important role in tissue repair and reconstruction. Recent knowledge shows that platelets can play a new role in tissue reproduction and vascular restoration, as well as being the protagonists of inflammatory processes and immune system responses. They release bio-active proteins and other active ingredients that can affect a number of phenomena that promote cell consumption, growth and transformation (growth factors).

Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis. It is a single-stranded RNA virus of the Paramyxoviridae family that is transmitted through nasopharyngeal or conjunctival mucosa from infected individuals. The incubation period ranges from 2 to 8 days.