Research Article Open Access
Volume 2 | Issue 1 | DOI: https://doi.org/10.33696/Nanotechnol.2.018

Nanofibers Based on Concentrated Collagen Hydrolysate Loaded with Essential Oils

  • 1Leather and Footwear Research Institute Division, National Research and Development Institute for Textiles and Leather, Bucharest, Romania
  • 2Faculty of Technology, University of Novi Sad, Novi Sad, Serbia
  • 3Center for Research and Eco-Metallurgical Expertise, Politehnica University of Bucharest, Bucharest, Romania
+ Affiliations - Affiliations

Corresponding Author

M. D. Berechet, marianadanielaberechet@yahoo.co.uk

Received Date: November 24, 2020

Accepted Date: December 22, 2020


Collagen is a biopolymer with regenerative and tissue reconstruction properties used in various treatments in medicine, but few research studies were dedicated to the electrospinning of collagen derivatives loaded with essential oils as efficient antimicrobial biomaterial.

This research aimed to obtain antibacterial nanofibers based on concentrated collagen hydrolysate loaded with cloves and cinnamon essential oils as natural alternatives to synthesis products. The essential oils were successfully incorporated into collagen using electrospinning process, resulting in nanofibers with diameter from 404.8 nm to 717.6 nm and porous structure. The presence of essential oils in collagen nanofiber mats was confirmed by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), Ultraviolet–visible spectroscopy (UV–VIS) and antibacterial activity assays. Scanning Electron Microscopy with Energy Dispersive Spectroscopy analyses allowed evaluating the morphology and constituent elements of the nanofiber networks. Microbiological tests performed against Escherichia coli, Staphylococcus aureus and Candida albicans showed that the presence of essential oils supplemented the new collagen nanofibers with antibacterial properties. Optimization of electrospinning parameters has led to the obtaining of new collagen electrospun nanofiber mats loaded with essential oils with potential use for wound dressings, tissue engineering or protective clothing.


Antibacterial nanofibers, Collagen hydrolysate, Clove and cinnamon essential oils, Bioactive nanofibers

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