Alzheimer’s disease (AD) represents the most common cause of dementia. Even if AD is commonly viewed as a disorder primarily of memory, there are several other additional domains, including visual function.

The concept of immunotherapy has been traced as far back to third century BC Qin dynasty in China through the purposeful inoculation of Variola minor to prevent smallpox. 

Motor Neuron Disease (MND) of which Amyotrophic lateral sclerosis (ALS) is the most common form, is a devastating disorder where approximately 80% of patients die within 3-5 years of diagnosis. The highly variable clinical presentation, course, and prognosis between individuals suggests that a variety of factors underlie the pathogenesis of the disease.

With the increasing need for targeted therapies in non-small cell lung carcinoma (NSCLC), preserving sufficient biopsy material has become essential. As most lung cancer cases are advanced or inoperable at the time of diagnosis, small biopsies, including cytology specimens, often serve as the only source of diagnostic material. Accurate subclassification of adenocarcinoma and squamous cell carcinoma in NSCLC using a limited panel including TTF1 and p63/p40 immunohistochemical (IHC) staining, as well as confirming small cell carcinoma using essential IHC markers, is critical for precise diagnosis, cost-effective treatment, and optimal patient care.

Bardet-Biedl Syndrome (BBS) is a rare autosomal recessive disorder characterized by retinal degeneration leading to blindness. This study investigates the therapeutic efficacy of N-Acetylcysteine (NAC), an oxygen free radical scavenger, in ameliorating retinal degeneration associated with BBS using a murine model of BBS10. BBS is caused by mutations in BBS genes, the protein products of which are involved in ciliary function; mutant or absent BBS10 protein disrupts the assembly of the BBSome protein complex, disturbing ciliary trafficking and leading to photoreceptor cell dysfunction and death.