Abstract
Due to deregulated control of the cell cycle, proliferation and metabolism, cancer cells are constantly exposed to a wide range of stresses, including DNA damage, nutrient deprivation, heat shock, hypoxia, and oxidative stresses, often, in a non-exclusive manner. Maintaining homeostasis, survival, and proliferation under these adverse conditions is a hallmark of cancer cells. Understanding the factors that enable cancer cells to endure such harsh environments is an important topic in cancer pathology. Recently, the range of these factors have expanded from regulatory proteins, mostly described as oncogenes and tumor suppressors, to non-coding RNAs, particularly long non-coding RNAs (lncRNA). LncRNAs have been found to play crucial roles in regulating stress responses at the molecular level, with implications on cell survival and tumor initiation and progression. In this review, we explore recent studies that underscore the importance of lncRNA in regulating cellular stress responses, homeostasis, and survival.
Keywords
LncRNA, Stress, DNA damage, Hypoxia, Oxidative stress, Metabolic reprograming