Laron syndrome (LS) is a rare form of dwarfism caused by defects in the growth hormone receptor causing congenital IGF-I deficiency. The effects of the IGF-I deficiency and its administration on the carbohydrate metabolism was studied in a cohort of 75 patients with LS. IGF-I deficiency in young children is accompanied by hypoglycemia, but progressive obesity leads to insulin resistance and glucose intolerance. Administration of endogenous IGF-I causes hypoglycemia independent of insulin.
Laron Syndrome, IGF-I, Hypoglycemia, Diabetes, Carbohydrate Metabolism