Commentary Open Access
Volume 3 | Issue 4 | DOI: https://doi.org/10.33696/diabetes.3.047

Lessons from Laron Syndrome on the Role of IGF-I on Carbohydrate Metabolism

  • 1Schneider Children’s Medical Center Sackler Faculty of Medicine, Tel Aviv University, Israel
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Corresponding Author

Zvi Laron, Laronz@clalit.org.il

Received Date: August 30, 2021

Accepted Date: September 21, 2021


Laron syndrome (LS) is a rare form of dwarfism caused by defects in the growth hormone receptor causing congenital IGF-I deficiency. The effects of the IGF-I deficiency and its administration on the carbohydrate metabolism was studied in a cohort of 75 patients with LS. IGF-I deficiency in young children is accompanied by hypoglycemia, but progressive obesity leads to insulin resistance and glucose intolerance. Administration of endogenous IGF-I causes hypoglycemia independent of insulin.


Laron Syndrome, IGF-I, Hypoglycemia, Diabetes, Carbohydrate Metabolism

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