The concept of immunotherapy has been traced as far back to third century BC Qin dynasty in China through the purposeful inoculation of Variola minor to prevent smallpox. 

Supracondylar fractures of the humerus are the most common elbow fracture in the pediatric population and comprise nearly 60% of all elbow fractures. Supracondylar fractures most commonly occur in children aged five to seven. Historically, males had a higher incidence of supracondylar humeral fractures. More recent studies support a more equal distribution amongst males and females.

Merkel cell carcinoma (MCC) is a rare, highly aggressive, neuroendocrine cancer of the skin with an increasing incidence. MCC occurs predominantly in older adults with risk factors including high exposure to ultra-violet (UV) light and immunosuppression.

Palliative care (PC) aims to prioritize the quality of life and comfort of those with complex and terminal illnesses through the physical, psychological, social, and spiritual needs of the individual. Palliative care can support individuals from the day of their cancer diagnosis through end-of-life and bereavement

With the increasing need for targeted therapies in non-small cell lung carcinoma (NSCLC), preserving sufficient biopsy material has become essential. As most lung cancer cases are advanced or inoperable at the time of diagnosis, small biopsies, including cytology specimens, often serve as the only source of diagnostic material. Accurate subclassification of adenocarcinoma and squamous cell carcinoma in NSCLC using a limited panel including TTF1 and p63/p40 immunohistochemical (IHC) staining, as well as confirming small cell carcinoma using essential IHC markers, is critical for precise diagnosis, cost-effective treatment, and optimal patient care.