For over a century, the therapeutic potential of electrical stimulation (ES) has intrigued scientists and clinicians alike. The ophthalmology field has largely centered its applications in posterior segment diseases of the eye, yet recent developments have brought corneal pathologies into sharper focus. This commentary aims to contextualize and critique the current landscape of ES in eye care, particularly the growing interest in the non-invasive techniques: transpalpebral electrical stimulation (TpES). Compared to transcorneal approaches, TpES not only preserves ocular surface integrity, but also enhances patient comfort and compliance—factors often overlooked in early clinical studies. Moreover, ES demonstrates promising neuroprotective, regenerative, and anti-inflammatory properties, extending its therapeutic relevance beyond neurons to glial and epithelial cell populations. Despite these advances, significant gaps remain. The diversity of stimulation parameters, variability in clinical protocols, and limited mechanistic understanding continue to hinder broader clinical translation. We argue that future progress depends on the development of standardized treatment regimens and the execution of large-scale, controlled trials. As such, ES stands at the intersection of innovation and implementation, offering an exciting, albeit complex, path forward in ocular therapeutics.

Electrical stimulation, Transpalpebral electrical stimulation (TpES), Neuroprotection, Dry eye, Anti-inflammation