Artificial Intelligence (AI) techniques represent a fascinating, provocative, and challenging discipline, are pervasive and of global importance. The European Commission summarized the current state in a White Paper on AI issues released on 19 February 2020, discussing various AI concepts that revolutionized many complex processes

Rituximab is a chimeric (20% rodent and 80% human) monoclonal antibody that binds to the CD20 antigen present on the cell surface and leads to depletion of mature B-cells [1,2]. It is the first approved monoclonal antibody to be used in the therapy of indolent B-cell non- Hodgkin’s lymphoma and chronic lymphocytic leukemia

5-fluorouracil (5-FU), an antimetabolite in the fluoropyrimidine class, is the third most commonly used chemotherapeutic agent worldwide for the treatment of solid malignancies [1]. Despite advances in novel cancer therapies, commonly used in combination with fluoropyrimidines, 5-FU remains one of the most effective and safe chemotherapy agents to manage colorectal cancer (CRC).

The presence of cold hyperalgesia may indicate widespread pain sensitivity or central pain augmentation. Its presence has been associated with poor outcomes in a range of chronic pain conditions and may offer an important prognostic indicator for persistent pain. Cold pain threshold (CPT) is considered the “gold standard”.

Medical management of hypertension in pregnancy is indicated for severe range blood pressures. This is diagnosed with either systolic blood pressure (SBP) ≥ 160 mm Hg and/or diastolic blood pressure (DBP) ≥110 mm Hg on two occasions at least 4 hours apart. When this diagnosis is established, fast-acting anti-hypertensive medications can be utilized for acutely severe range blood pressures.